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List of works by Young G Shin

A Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometric Assay for the Quantification of Fabry Disease Biomarker Globotriaosylceramide (GB3) in Fabry Model Mouse.

scientific article published on 7 June 2018

A cytotoxic diterpene from Alomia myriadenia

scientific article published on 01 April 2000

A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry.

scientific article published on 20 May 2011

A single liquid chromatography-quadrupole time-of-flight mass spectrometric method for the quantification of total antibody, antibody-conjugated drug and free payload of antibody-drug conjugates.

scientific article published on 5 March 2018

Analysis of Vipadenant and Its In Vitro and In Vivo Metabolites via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

scholarly article by Seok-Ho Shin et al published 3 December 2018 in Pharmaceutics

Application of Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Antibody-Drug Conjugate Development

scientific article

Chemical constituent ofAloe capensis.

scientific article published in April 1997

Chemical constituents inAloe barbadensis

scientific article published on 01 February 1997

Comparison of metabolic soft spot predictions of CYP3A4, CYP2C9 and CYP2D6 substrates using MetaSite and StarDrop

scientific article published on 01 November 2011

Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea.

scientific article

Determination of aloesin in plasma by high-performance liquid chromatography as fluorescent 9-anthroyl derivative

scientific article published on 01 December 1998

Determination of betaine in Lycium chinense fruits by liquid chromatography-electrospray ionization mass spectrometry

scientific article published on 01 October 1999

Determination of loperamide in mdr1a/1b knock-out mouse brain tissue using matrix-assisted laser desorption/ionization mass spectrometry and comparison with quantitative electrospray-triple quadrupole mass spectrometry analysis.

scientific article

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

scientific article

Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats

scientific article published on 20 July 2019

Human microdosing and mice xenograft data of AGM-130 applied to estimate efficacious doses in patients.

scientific article

In Vitro, In Silico, and In Vivo Assessments of Pharmacokinetic Properties of ZM241385

scientific article published on 02 March 2020

Liquid chromatography-high resolution mass spectrometric method for the quantification of monomethyl auristatin E (MMAE) and its preclinical pharmacokinetics

scientific article published on 17 April 2020

Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.

scientific article

Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing ⬇️

scientific article published on April 12, 2013

New bioactive coumarins from Kielmeyera albopunctata.

scientific article published on May 2003

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor.

scientific article published in November 2009

Profiling and Identification of Omeprazole Metabolites in Mouse Brain and Plasma by Isotope Ratio-Monitoring Liquid Chromatography-Mass Spectrometric Method

scientific article published on 19 July 2020

Qualification and Application of a Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method for the Determination of Adalimumab in Rat Plasma

scientific article published on 24 May 2018

Qualification and application of a liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of trastuzumab in rat plasma.

scientific article published on 28 August 2015

Qualification and application of liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic mo

scientific article published on 23 September 2020

Quantitative Analysis of Tozadenant Using Liquid Chromatography-Mass Spectrometric Method in Rat Plasma and Its Human Pharmacokinetics Prediction Using Physiologically Based Pharmacokinetic Modeling

scientific article published on 02 April 2019

Rapid and simultaneous quantification of a mixture of biopharmaceuticals by a liquid chromatography/quadrupole time-of-flight mass spectrometric method in rat plasma following cassette-dosing

scientific article published on 01 June 2018

Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility

scientific article published on 6 March 2018

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)

scientific article

Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor ⬇️

scientific article published on July 8, 2011

Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

scientific article

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of G-856 (Cur-61414) in human plasma using semi-automated solid phase extraction

scientific article published on 25 January 2012

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0879 and its metabolite in dog plasma using solid phase extraction.

scientific article published in June 2012

Validation and application of a liquid chromatography‐tandem mass spectrometric method for the determination of GDC‐0152 in human plasma using solid‐phase extraction ⬇️

scientific article published on May 24, 2012

Validation and application of a liquid chromatography–tandem mass spectrometric method for the determination of GDC‐0834 and its metabolite in human plasma using semi‐automated 96‐well protein precipitation ⬇️

scientific article published on February 7, 2012

Validation of a liquid chromatography-triple quadrupole mass spectrometric method for the determination of 5-nitro-5'-hydroxy-indirubin-3'-oxime (AGM-130) in human plasma and its application to microdose clinical trial

scientific article published on 2 July 2015

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