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List of works by Hagit Eldar-Finkelman

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

scientific article published on 15 November 2016

Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment

scientific article

Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth.

scientific article

Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue

scientific article

Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors

scientific article

Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site

scientific article published on 18 November 2020

Distinct molecular regulation of glycogen synthase kinase-3alpha isozyme controlled by its N-terminal region: functional role in calcium/calpain signaling

scientific article

Elucidating substrate and inhibitor binding sites on the surface of GSK-3β and the refinement of a competitive inhibitor

scientific article published on 25 February 2011

Exploiting substrate recognition for selective inhibition of protein kinases

scientific article published on January 2012

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS ⬇️

scientific article published on October 31, 2011

GSK-3 and lysosomes meet in Alzheimer's disease

scientific article published on 4 June 2013

GSK-3 inhibition: achieving moderate efficacy with high selectivity

scientific article published on 29 January 2013

GSK-3β Inhibition Affects Singing Behavior and Neurogenesis in Adult Songbirds

scientific article published on 6 June 2015

GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer

scientific article

Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.

scientific article published on 13 May 2010

Glycogen synthase kinase 3: an emerging therapeutic target

scientific article

Glycogen synthase kinase-3--a promising therapeutic target: Dr Hagit Eldar-Finkelman interviewed by Emma Quigley

scientific article published in April 2006

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3.

scientific article published on 12 August 2010

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

scientific article published on May 2012

Identification of novel glycogen synthase kinase-3beta substrate-interacting residues suggests a common mechanism for substrate recognition

scientific article

Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice

scientific article published on August 2003

Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies

scientific article published on 15 November 2012

Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc

scientific article published on July 2002

Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.

scientific article published on 6 March 2003

Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.

scientific article published on 23 March 2017

Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.

scientific article published on 10 October 2016

Lithium-mediated phosphorylation of glycogen synthase kinase-3beta involves PI3 kinase-dependent activation of protein kinase C-alpha

scientific article published on January 2004

Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle

scientific article

Monitor and Molecules

scientific article published in October 2001

New insights into the autoinhibition mechanism of glycogen synthase kinase-3beta

scientific article published on 9 September 2008

Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner.

scientific article published on 28 January 2008

PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase

scientific article published on 26 October 2004

Peptide inhibitors targeting protein kinases

scientific article published on January 2009

Peptides targeting protein kinases: strategies and implications

scientific article published on December 2006

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action ⬇️

scientific article published on September 2, 1997

Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

scientific article published in April 2004

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

scientific article published on 19 April 2013

Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury.

scientific article published on 28 December 2006

Science Signaling Podcast for 15 November 2016: A new type of kinase inhibitor

scientific article published on 15 November 2016

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

scholarly article by Lina Tsaadon Alon published in March 2011

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

scientific article

Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling

scientific article

Structure-based optimization of oxadiazole-based GSK-3 inhibitors.

scientific article

Substrate competitive GSK-3 inhibitors - strategy and implications

scientific article published on 18 September 2009

Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.

scientific article

The SIL gene is essential for mitotic entry and survival of cancer cells.

scientific article published on 24 April 2007

The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes

scientific article

Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition

scientific article published on 16 August 2016

Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide

scientific article published on 24 January 2011

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