List of works - Miriam Eisenstein

A Unique Spatial Arrangement of the snRNPs within the Native Spliceosome Emerges from In Silico Studies ⬇️

scientific article published on May 10, 2012

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

scientific article published on 15 November 2016

Activation and control of pathogenic T cells in OSP/claudin-11-induced EAE in SJL/J mice are dominated by their focused recognition of a single epitopic residue (OSP58M).

scientific article published on 18 September 2008

Anti-GalNAcβ: a novel anti-glycan autoantibody associated with pregnancy loss in women with antiphospholipid syndrome and in a mouse experimental model

scientific article

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential ⬇️

scientific article published on December 25, 2011

Antibody recognition of chiral surfaces. Enantiomorphous crystals of leucine-leucine-tyrosine

scientific article published in January 2003

Antibody recognition of chiral surfaces. Structural models of antibody complexes with leucine-leucine-tyrosine crystal surfaces

scientific article

Bioorganometallic chemistry

Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice

scientific article published on 18 August 2014

Blind prediction of interfacial water positions in CAPRI

scientific article

CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome

scientific journal article

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

scientific article published in Nature

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

Characterization of the AGPase large subunit isoforms from tomato indicates that the recombinant L3 subunit is active as a monomer.

scientific article

Combining interface core and whole interface descriptors in postscan processing of protein-protein docking models

scientific article

Computational mapping of anchoring spots on protein surfaces

scientific article published on 17 July 2010

Construction of molecular assemblies via docking: modeling of tetramers with D2 symmetry

scientific article published in December 2003

Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain

scientific article published on 2 September 2008

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

scientific article

Electrostatics in protein-protein docking

scientific article

Elucidating substrate and inhibitor binding sites on the surface of GSK-3β and the refinement of a competitive inhibitor

scientific article published on 25 February 2011

Experimental and computational characterization of the dimerization of the PTS-regulation domains of BglG from Escherichia coli

scientific article

FitEM2EM--tools for low resolution study of macromolecular assembly and dynamics

scientific article

GSK-3 inhibition: achieving moderate efficacy with high selectivity

scientific article published on 29 January 2013

Helminths-based bi-functional molecule, tuftsin-phosphorylcholine (TPC), ameliorates an established murine arthritis

scientific article published in PLoS ONE

Hsp90 Recognizes a Common Surface on Client Kinases

scientific article published in Journal of Biological Chemistry

Hydrophobic complementarity in protein-protein docking

scientific article published in July 2004

Identification of novel glycogen synthase kinase-3beta substrate-interacting residues suggests a common mechanism for substrate recognition

scientific article

Inherent limitations in protein-protein docking procedures

scientific article published on 12 October 2006

Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: molecular and behavioral aspects

scientific article published on 22 April 2013

Interrelation between hydration and interheadgroup interaction in phospholipids

scientific article published in December 2002

It depends on the hinge: a structure-functional analysis of galectin-8, a tandem-repeat type lectin

scientific article published on 24 February 2006

Ligand interaction scan: a general method for engineering ligand-sensitive protein alleles

scientific article published on 22 April 2007

Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies

scientific article

Looking at enzymes from the inside out: the proximity of catalytic residues to the molecular centroid can be used for detection of active sites and enzyme-ligand interfaces

scientific article published in August 2005

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

scientific article published on 27 December 2011

Modeling oligomers with Cn or Dn symmetry: application to CAPRI target 10.

scientific article published in August 2005

Modulation of the hydrophobic domain of polymyxin B nonapeptide: effect on outer-membrane permeabilization and lipopolysaccharide neutralization.

scientific article

Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase

scientific article published on October 2015

Monoclonal antibody to a DNA-binding domain of p53 mimics charge structure of DNA: anti-idiotypes to the anti-p53 antibody are anti-DNA.

scientific article

New insights into the autoinhibition mechanism of glycogen synthase kinase-3beta

scientific article published on 9 September 2008

Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy.

scientific article

OSP/claudin-11-induced EAE in mice is mediated by pathogenic T cells primarily governed by OSP192Y residue of major encephalitogenic region OSP179-207.

scientific article published on July 2007

On proteins, grids, correlations, and docking

scientific article published in May 2004

On the interaction of colicin E3 with the ribosome.

scientific article

Peptide inhibitors targeting protein kinases

scientific article published on January 2009

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL.

scientific article published on 2 July 2009

Prediction of the structure of the complex between the 30S ribosomal subunit and colicin E3 via weighted-geometric docking

scientific article published in April 2003

Prediction of the unknown: inspiring experience with the CAPRI experiment

scientific article published in July 2003

Protein recognition by bivalent, 'turn-on' fluorescent molecular probes

scientific article published on 12 June 2015

Removing allosteric feedback inhibition of tomato 4‐coumarate:CoA ligase by directed evolution ⬇️

scientific article published on October 17, 2011

Role of galectin-8 as a modulator of cell adhesion and cell growth

scientific article (publication date: 2004)

Structure of the DNA-SspC complex: implications for DNA packaging, protection, and repair in bacterial spores

scientific article

Substrate competitive GSK-3 inhibitors - strategy and implications

scientific article published on 18 September 2009

Systemic lupus erythematosus-associated neutrophil cytosolic factor 2 mutation affects the structure of NADPH oxidase complex

scientific article published on 20 March 2015

The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases

scientific article

The conserved Glu-60 residue in Thermoanaerobacter brockii alcohol dehydrogenase is not essential for catalysis

scientific article published on March 2003

The crystal structure of the C-terminal DAP5/p97 domain sheds light on the molecular basis for its processing by caspase cleavage

scientific article

The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs

scientific article published on 16 November 2008

The evolutionary origin of the Runx/CBFbeta transcription factors--studies of the most basal metazoans

scientific article (publication date: 5 August 2008)

The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR

scientific article

The myelin-associated oligodendrocytic basic protein (MOBP) as a relevant primary target autoantigen in multiple sclerosis

scientific article published on 13 August 2009

The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501.

scientific article published in July 2004

The olfactory receptor universe--from whole genome analysis to structure and evolution.

scientific article

The regulation of death-associated protein (DAP) kinase in apoptosis.

scientific article

The structure and synthetic capabilities of a catalytic peptide formed by substrate-directed mechanism--implications to prebiotic catalysis

scientific article

The topology, in model membranes, of the core peptide derived from the T-cell receptor transmembrane domain

scientific article published on 24 July 2013

Topology of the trans-membrane peptide WALP23 in model membranes under negative mismatch conditions

scientific article published on 14 February 2013

Variable internal flexibility characterizes the helical capsid formed by agrobacterium VirE2 protein on single-stranded DNA

scientific article

Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase

scientific article published on 27 September 2006

Water-induced pyroelectricity from nonpolar crystals of amino acids

scientific article published on 6 May 2013

Weighted geometric docking: incorporating external information in the rotation-translation scan

scientific article published in July 2003

β2-Glycoprotein-I based peptide regulate endothelial-cells tissue-factor expression via negative regulation of pGSK3β expression and reduces experimental-antiphospholipid-syndrome.

scientific article

List of works by Miriam Eisenstein

A Unique Spatial Arrangement of the snRNPs within the Native Spliceosome Emerges from In Silico Studies ⬇️

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

Activation and control of pathogenic T cells in OSP/claudin-11-induced EAE in SJL/J mice are dominated by their focused recognition of a single epitopic residue (OSP58M).

Anti-GalNAcβ: a novel anti-glycan autoantibody associated with pregnancy loss in women with antiphospholipid syndrome and in a mouse experimental model

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential ⬇️

Antibody recognition of chiral surfaces. Enantiomorphous crystals of leucine-leucine-tyrosine

Antibody recognition of chiral surfaces. Structural models of antibody complexes with leucine-leucine-tyrosine crystal surfaces

Bioorganometallic chemistry

Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice

Blind prediction of interfacial water positions in CAPRI

CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

Characterization of the AGPase large subunit isoforms from tomato indicates that the recombinant L3 subunit is active as a monomer.

Combining interface core and whole interface descriptors in postscan processing of protein-protein docking models

Computational mapping of anchoring spots on protein surfaces

Construction of molecular assemblies via docking: modeling of tetramers with D2 symmetry

Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

Electrostatics in protein-protein docking

Elucidating substrate and inhibitor binding sites on the surface of GSK-3β and the refinement of a competitive inhibitor

Experimental and computational characterization of the dimerization of the PTS-regulation domains of BglG from Escherichia coli

FitEM2EM--tools for low resolution study of macromolecular assembly and dynamics

GSK-3 inhibition: achieving moderate efficacy with high selectivity

Helminths-based bi-functional molecule, tuftsin-phosphorylcholine (TPC), ameliorates an established murine arthritis

Hsp90 Recognizes a Common Surface on Client Kinases

Hydrophobic complementarity in protein-protein docking

Identification of novel glycogen synthase kinase-3beta substrate-interacting residues suggests a common mechanism for substrate recognition

Inherent limitations in protein-protein docking procedures

Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: molecular and behavioral aspects

Interrelation between hydration and interheadgroup interaction in phospholipids

It depends on the hinge: a structure-functional analysis of galectin-8, a tandem-repeat type lectin

Ligand interaction scan: a general method for engineering ligand-sensitive protein alleles

Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies

Looking at enzymes from the inside out: the proximity of catalytic residues to the molecular centroid can be used for detection of active sites and enzyme-ligand interfaces

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

Modeling oligomers with Cn or Dn symmetry: application to CAPRI target 10.

Modulation of the hydrophobic domain of polymyxin B nonapeptide: effect on outer-membrane permeabilization and lipopolysaccharide neutralization.

Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase

Monoclonal antibody to a DNA-binding domain of p53 mimics charge structure of DNA: anti-idiotypes to the anti-p53 antibody are anti-DNA.

New insights into the autoinhibition mechanism of glycogen synthase kinase-3beta

Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy.

OSP/claudin-11-induced EAE in mice is mediated by pathogenic T cells primarily governed by OSP192Y residue of major encephalitogenic region OSP179-207.

On proteins, grids, correlations, and docking

On the interaction of colicin E3 with the ribosome.

Peptide inhibitors targeting protein kinases

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL.

Prediction of the structure of the complex between the 30S ribosomal subunit and colicin E3 via weighted-geometric docking

Prediction of the unknown: inspiring experience with the CAPRI experiment

Protein recognition by bivalent, 'turn-on' fluorescent molecular probes

Removing allosteric feedback inhibition of tomato 4‐coumarate:CoA ligase by directed evolution ⬇️

Role of galectin-8 as a modulator of cell adhesion and cell growth

Structure of the DNA-SspC complex: implications for DNA packaging, protection, and repair in bacterial spores

Substrate competitive GSK-3 inhibitors - strategy and implications

Systemic lupus erythematosus-associated neutrophil cytosolic factor 2 mutation affects the structure of NADPH oxidase complex

The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases

The conserved Glu-60 residue in Thermoanaerobacter brockii alcohol dehydrogenase is not essential for catalysis

The crystal structure of the C-terminal DAP5/p97 domain sheds light on the molecular basis for its processing by caspase cleavage

The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs

The evolutionary origin of the Runx/CBFbeta transcription factors--studies of the most basal metazoans

The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR

The myelin-associated oligodendrocytic basic protein (MOBP) as a relevant primary target autoantigen in multiple sclerosis

The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501.

The olfactory receptor universe--from whole genome analysis to structure and evolution.

The regulation of death-associated protein (DAP) kinase in apoptosis.

The structure and synthetic capabilities of a catalytic peptide formed by substrate-directed mechanism--implications to prebiotic catalysis

The topology, in model membranes, of the core peptide derived from the T-cell receptor transmembrane domain

Topology of the trans-membrane peptide WALP23 in model membranes under negative mismatch conditions

Variable internal flexibility characterizes the helical capsid formed by agrobacterium VirE2 protein on single-stranded DNA

Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase

Water-induced pyroelectricity from nonpolar crystals of amino acids

Weighted geometric docking: incorporating external information in the rotation-translation scan

β2-Glycoprotein-I based peptide regulate endothelial-cells tissue-factor expression via negative regulation of pGSK3β expression and reduces experimental-antiphospholipid-syndrome.