List of works - Gabriel Birrane

31P and 2H relaxation studies of helix VII and the cytoplasmic helix of the human cannabinoid receptors utilizing solid-state NMR techniques.

scientific article

Cigarette smoke induces nuclear translocation of heme oxygenase 1 (HO-1) in prostate cancer cells: nuclear HO-1 promotes vascular endothelial growth factor secretion

scientific article published on 17 April 2013

Crystal structure of the BARD1 BRCT domains

scientific article

Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains

scientific article

Crystallization and preliminary X-ray analysis of a complex of the FOXO1 and Ets1 DNA-binding domains and DNA.

scientific article published on 24 December 2013

Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor

scientific article published on 24 April 2001

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN. ⬇️

scientific article published on 29 December 2017

Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes

scientific article

Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing.

scientific article

GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism

scientific article published on 01 July 2019

Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity

scientific article

Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly

scientific article

Identification of the PDZ3 Domain of the Adaptor Protein PDZK1 as a Second, Physiologically Functional Binding Site for the C Terminus of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I

scientific article

In Vitro and in Vivo Analysis of the Binding of the C Terminus of the HDL Receptor Scavenger Receptor Class B, Type I (SR-BI), to the PDZ1 Domain of Its Adaptor Protein PDZK1 ⬇️

scientific article published on August 25, 2010

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex

scientific article published on 3 July 2017

Large protein organelles form a new iron sequestration system with high storage capacity

scientific article published on 08 July 2019

Lipoprotein lipase is active as a monomer

scientific article published on 08 March 2019

March1-dependent modulation of donor MHC II on CD103 dendritic cells mitigates alloimmunity

scientific article published in Nature Communications

Molecular Analysis of the Prostacyclin Receptor’s Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1

scientific article

NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function.

scientific article published on 9 March 2017

NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors.

scientific article

Novel mode of ligand recognition by the Erbin PDZ domain

scientific article

Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach

scientific article

Structural basis for DNA recognition by the human PAX3 homeodomain

scientific article

Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.

scientific article published in August 2005

Structural basis for polyproline recognition by the FE65 WW domain

scientific article

Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B

scientific article published on 23 February 2019

Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis

scientific article published on 17 December 2018

Synthesis of Aspartame by Thermolysin: An X-ray Structural Study

scientific article

TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release

scientific article

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

scientific article published on 20 July 2020

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

scientific article published on 07 February 2020

List of works by Gabriel Birrane

31P and 2H relaxation studies of helix VII and the cytoplasmic helix of the human cannabinoid receptors utilizing solid-state NMR techniques.

Cigarette smoke induces nuclear translocation of heme oxygenase 1 (HO-1) in prostate cancer cells: nuclear HO-1 promotes vascular endothelial growth factor secretion

Crystal structure of the BARD1 BRCT domains

Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains

Crystallization and preliminary X-ray analysis of a complex of the FOXO1 and Ets1 DNA-binding domains and DNA.

Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN. ⬇️

Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes

Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing.

GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism

Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity

Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly

Identification of the PDZ3 Domain of the Adaptor Protein PDZK1 as a Second, Physiologically Functional Binding Site for the C Terminus of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I

In Vitro and in Vivo Analysis of the Binding of the C Terminus of the HDL Receptor Scavenger Receptor Class B, Type I (SR-BI), to the PDZ1 Domain of Its Adaptor Protein PDZK1 ⬇️

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex

Large protein organelles form a new iron sequestration system with high storage capacity

Lipoprotein lipase is active as a monomer

March1-dependent modulation of donor MHC II on CD103 dendritic cells mitigates alloimmunity

Molecular Analysis of the Prostacyclin Receptor’s Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1

NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function.

NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors.

Novel mode of ligand recognition by the Erbin PDZ domain

Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach

Structural basis for DNA recognition by the human PAX3 homeodomain

Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.

Structural basis for polyproline recognition by the FE65 WW domain

Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B

Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis

Synthesis of Aspartame by Thermolysin: An X-ray Structural Study

TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism