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List of works by Jean Lesage

Altered hypothalamo-pituitary-adrenal and sympatho-adrenomedullary activities in rats bred for high anxiety: central and peripheral correlates.

scientific article

Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat.

scientific article

Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition.

scientific article published on 2 December 2015

Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents.

scientific article published on 14 August 2013

Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice.

scientific article

Consequences of prenatal morphine exposure on the hypothalamo-pituitary-adrenal axis in the newborn rat: effect of maternal adrenalectomy.

scientific article

Could maternal perinatal atypical antipsychotic treatments program later metabolic diseases in the offspring?

scientific article published on 12 June 2011

Depot- and sex-specific effects of maternal obesity in offspring's adipose tissue

scientific article published on 27 April 2016

Discovery of Toddler/Elabela ligand and the double life of the apelin receptor

scientific article published in May 2015

Do neurotrophins regulate the feto-placental development?

scientific article published on 04 March 2011

Effect of cholinergic blockade on glucocorticoid regulation of NPY and catecholamines in the rat adrenal gland

scientific article published on 01 August 1997

Effect of natriuretic peptides on in vitro stimulated adrenocorticotropic hormone release and pro-opiomelanocortin mRNA expression by the fetal rat pituitary gland in late gestation.

scientific article published in January 2003

Effects of moderate and intensive training on the hypothalamo-pituitary-adrenal axis in rats.

scientific article published in June 2002

Effects of prenatal morphine on hypothalamic metabolism of neurotransmitters and gonadal and adrenal activities, during the early postnatal period in the rat.

scientific article published in June 1996

Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner.

scientific article published on 15 June 2015

Food-Derived Hemorphins Cross Intestinal and Blood-Brain Barriers In Vitro

scientific article

Glucocorticoids impair fetal beta-cell development in rats.

scientific article

HPA axis programming by maternal undernutrition in the male rat offspring.

scientific article published on 17 July 2007

Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats.

scientific article published on 21 August 2006

Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes.

scientific article published on 18 September 2013

Hypothalamic metabolism of neurotransmitters (serotonin, norepinephrine, dopamine) and NPY, and gonadal and adrenal activities, during the early postnatal period in the rat.

scientific article published in January 1996

Influence of morphine treatment in pregnant rats on the mineralocorticoid activity of the adrenals in their neonates

scientific article

Influence of prenatal undernutrition on the effects of clozapine and aripiprazole in the adult male rats: relevance to a neurodevelopmental origin of schizophrenia?

scientific article published on 15 April 2011

Isolation and characterization of a leech neuropeptide in rat brains: coupling to nitric oxide release in leech, rat and human tissues

scientific article published on March 30, 1998

Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats

scientific article published on 23 October 2012

Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta

scientific article

Maternal hypertension induced by NO blockade does not program adult metabolic diseases in growth-restricted rat fetuses.

scientific article published on 30 October 2012

Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat

scientific article published on 15 March 2012

Maternal obesity alters the apelinergic system at the feto-maternal interface.

scientific article published on 12 January 2016

Maternal obesity programs increased leptin gene expression in rat male offspring via epigenetic modifications in a depot-specific manner

scientific article

Maternal perinatal undernutrition alters neuronal and neuroendocrine differentiation in the rat adrenal medulla at weaning

scientific journal article

Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups.

scientific article published on 15 November 2007

Maternal perinatal undernutrition modifies lactose and serotranferrin in milk: relevance to the programming of metabolic diseases?

scientific article published on 30 December 2014

Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring

scientific journal article

Maternal prenatal undernutrition programs adipose tissue gene expression in adult male rat offspring under high-fat diet.

scientific article

Maternal stress alters endocrine function of the feto-placental unit in rats

scientific article published on 30 January 2007

Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring

scientific article published in February 2017

Perinatal undernutrition modifies cell proliferation and brain-derived neurotrophic factor levels during critical time-windows for hypothalamic and hippocampal development in the male rat.

scientific article

Placental BDNF/TrkB signaling system is modulated by fetal growth disturbances in rat and human.

scientific article published on 7 July 2010

Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rats and humans

scientific article published in April 2013

Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress

scientific journal article

Prenatal stress induces intrauterine growth restriction and programmes glucose intolerance and feeding behaviour disturbances in the aged rat.

scientific article

Reduced PPARγ2 expression in adipose tissue of male rat offspring from obese dams is associated with epigenetic modifications

scientific article published on 2 January 2018

Regulation of neuropeptide Y and its mRNA by glucocorticoids in the rat adrenal gland

scientific article published on 01 December 1995

Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet

scientific article (publication date: 21 December 2010)

Short- and long-term effects of maternal perinatal undernutrition are lowered by cross-fostering during lactation in the male rat.

scientific article published in April 2014

Simulated GI digestion of dietary protein: Release of new bioactive peptides involved in gut hormone secretion.

scientific article published on 27 August 2016

The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes.

scientific article published on 6 September 2011

The hypothalamic POMC mRNA expression is upregulated in prenatally undernourished male rat offspring under high-fat diet

scientific article published on March 20, 2013

Tissue-specific programming expression of glucocorticoid receptors and 11 beta-HSDs by maternal perinatal undernutrition in the HPA axis of adult male rats

scientific journal article

[BDNF in feto-placental development]

scientific article published on 30 March 2011

[Maternal nutritional manipulations: is the adipose tissue a key target of programming?]

scientific article published on 01 January 2016