List of works - Cristina Cecchi

A causative link between the structure of aberrant protein oligomers and their toxicity.

scientific article

A complex equilibrium among partially unfolded conformations in monomeric transthyretin

scientific article published in July 2014

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

scientific article

A peptide fraction from factor VIII reduces PKC activity in cultured endothelial cells.

scientific article

A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells

scientific article published on 6 August 2009

Acylphosphatase overexpression triggers SH-SY5Y differentiation towards neuronal phenotype.

scientific article published in July 2004

Alteration of acylphosphatase levels in familial Alzheimer's disease fibroblasts with presenilin gene mutations.

scientific article published in June 1996

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

scientific article

Biochemical changes and their relationship with morphological and functional findings in pig heart subjected to lasting volume overload: a possible role of acylphosphatase in the regulation of sarcoplasmic reticulum calcium pump.

scientific article published in November 2002

Biological membranes as protein aggregation matrices and targets of amyloid toxicity.

scientific article

Capturing Aβ42 aggregation in the cell

scientific article published in Journal of Biological Chemistry

Cerebral soluble ubiquitin is increased in patients with Alzheimer's disease

scientific article published in March 1993

Crystallisation and preliminary X-ray analysis of the 'common-type' acylphosphatase.

scientific article published in May 1995

Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia.

scientific article published on August 2016

Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF-N aggregates to different cell types

article

Early Changes Induced in the Left Ventricle by Pressure Overload. An Experimental Study on Swine Heart

scientific article published on 01 January 2000

Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations

scientific article published on 19 January 2016

Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.

scientific article published on 16 April 2013

Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways.

scientific article

Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease.

scientific article published in November 1999

Glycosaminoglycans (GAGs) suppress the toxicity of HypF-N prefibrillar aggregates.

scientific article published on 9 February 2012

Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation

scientific article published on 07 November 2019

Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts

scientific article published on 15 June 2006

Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates.

scientific article

Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy.

scientific article

Lack of SOD1 gene mutations and activity alterations in two Italian families with amyotrophic lateral sclerosis

article

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

scientific article

Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease

scientific article published in February 2013

Membrane cholesterol enrichment prevents Aβ-induced oxidative stress in Alzheimer's fibroblasts.

scientific article published on 17 March 2009

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.

scientific article

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models

scientific article published on 27 January 2012

Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions

scientific article

Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients

scientific article

Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases

scientific article published on 27 July 2019

Patterns of cell death triggered in two different cell lines by HypF-N prefibrillar aggregates.

scientific article

Plasma membrane injury depends on bilayer lipid composition in Alzheimer's disease

scientific article published on January 2014

Poly(ADP-ribose) polymerase activation and cell injury in the course of rat heart heterotopic transplantation.

scientific article

Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress

scientific article

Protective properties of novel S-acyl-glutathione thioesters against ultraviolet-induced oxidative stress.

scientific article published on October 2012

Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy

scientific article

Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity.

scientific article

S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans

scientific article published on 15 May 2014

SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes

scientific article published on 05 February 2012

SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival

scientific article

Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers.

scientific article published on 4 December 2015

Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload

scientific article published on 8 September 2017

Soluble Prion Peptide 107-120 Protects Neuroblastoma SH-SY5Y Cells against Oligomers Associated with Alzheimer's Disease

scientific article published on 01 October 2020

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

scientific article

TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells

scientific article published on 30 January 2014

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

scientific article published on 22 March 2021

Toxic HypF-N Oligomers Selectively Bind the Plasma Membrane to Impair Cell Adhesion Capability.

scientific article published in March 2018

Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity

scientific article published on 11 August 2014

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

scientific article published on 25 September 2013

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

List of works by Cristina Cecchi

A causative link between the structure of aberrant protein oligomers and their toxicity.

A complex equilibrium among partially unfolded conformations in monomeric transthyretin

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

A peptide fraction from factor VIII reduces PKC activity in cultured endothelial cells.

A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells

Acylphosphatase overexpression triggers SH-SY5Y differentiation towards neuronal phenotype.

Alteration of acylphosphatase levels in familial Alzheimer's disease fibroblasts with presenilin gene mutations.

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

Biochemical changes and their relationship with morphological and functional findings in pig heart subjected to lasting volume overload: a possible role of acylphosphatase in the regulation of sarcoplasmic reticulum calcium pump.

Biological membranes as protein aggregation matrices and targets of amyloid toxicity.

Capturing Aβ42 aggregation in the cell

Cerebral soluble ubiquitin is increased in patients with Alzheimer's disease

Crystallisation and preliminary X-ray analysis of the 'common-type' acylphosphatase.

Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia.

Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF-N aggregates to different cell types

Early Changes Induced in the Left Ventricle by Pressure Overload. An Experimental Study on Swine Heart

Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations

Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.

Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways.

Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease.

Glycosaminoglycans (GAGs) suppress the toxicity of HypF-N prefibrillar aggregates.

Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation

Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts

Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates.

Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy.

Lack of SOD1 gene mutations and activity alterations in two Italian families with amyotrophic lateral sclerosis

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease

Membrane cholesterol enrichment prevents Aβ-induced oxidative stress in Alzheimer's fibroblasts.

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models

Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions

Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients

Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases

Patterns of cell death triggered in two different cell lines by HypF-N prefibrillar aggregates.

Plasma membrane injury depends on bilayer lipid composition in Alzheimer's disease

Poly(ADP-ribose) polymerase activation and cell injury in the course of rat heart heterotopic transplantation.

Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress

Protective properties of novel S-acyl-glutathione thioesters against ultraviolet-induced oxidative stress.

Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy

Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity.

S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans

SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes

SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival

Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers.

Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload

Soluble Prion Peptide 107-120 Protects Neuroblastoma SH-SY5Y Cells against Oligomers Associated with Alzheimer's Disease

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

Toxic HypF-N Oligomers Selectively Bind the Plasma Membrane to Impair Cell Adhesion Capability.

Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism