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List of works by Mark S. McClain

A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation

scientific article

A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation

scientific article published on 01 December 1999

Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells

scientific article published on 01 July 2000

Amino-terminal hydrophobic region of Helicobacter pylori vacuolating cytotoxin (VacA) mediates transmembrane protein dimerization.

scientific article published on February 2001

Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin

scientific article

Bacterial Energetic Requirements for Helicobacter pylori Cag Type IV Secretion System-Dependent Alterations in Gastric Epithelial Cells

scientific article published on 22 January 2020

Coenzyme depletion by members of the aerolysin family of pore-forming toxins leads to diminished ATP levels and cell death ⬇️

scientific article published on June 11, 2012

Comparative genomic analysis of East Asian and non-Asian Helicobacter pylori strains identifies rapidly evolving genes.

scientific article

Construction of an alkaline phosphatase fusion-generating transposon, mTn10phoA.

scientific article

Control of gene expression in Helicobacter pylori using the Tet repressor

scientific article published on 8 October 2013

Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain

scientific article

Dominant-negative inhibitors of the Clostridium perfringens epsilon-toxin.

scientific article published on 31 August 2009

Dynamic Computational Model of Symptomatic Bacteremia to Inform Bacterial Separation Treatment Requirements

scientific article

Expression of Helicobacter pylori vacuolating toxin in Escherichia coli.

scientific article

Functional Properties of Oligomeric and Monomeric Forms of Helicobacter pylori VacA Toxin

scientific article published on 20 September 2021

Functional properties of Helicobacter pylori VacA toxin m1 and m2 variants

scientific article published on 13 April 2020

Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin.

scientific article

Gene-trap mutagenesis identifies mammalian genes contributing to intoxication by Clostridium perfringens ε-toxin

scientific article (publication date: 11 March 2011)

Genome Sequences of Three hpAfrica2 Strains of Helicobacter pylori

scientific article published on 26 September 2013

Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer

scientific article

Helicobacter pylori HopQ outer membrane protein attenuates bacterial adherence to gastric epithelial cells.

scientific article

Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells.

scientific article

Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface

scientific article

Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen

scientific article

Identification of amino acids important for binding of Clostridium perfringens epsilon toxin to host cells and to HAVCR1.

scientific article published on 12 September 2012

Interactions between p-33 and p-55 Domains of the Helicobacter pylori Vacuolating Cytotoxin (VacA)

scientific article published in Journal of Biological Chemistry

Lipoprotein Processing and Sorting in Helicobacter pylori

scientific article published on 19 May 2020

Mapping of a domain required for protein-protein interactions and inhibitory activity of a Helicobacter pylori dominant-negative VacA mutant protein.

scientific article published in April 2006

Oligomerization of Clostridium perfringens Epsilon Toxin Is Dependent upon Caveolins 1 and 2 ⬇️

scientific article published on October 2, 2012

Protein-protein interactions among Helicobacter pylori cag proteins

scientific article

Random mutagenesis of Helicobacter pylori vacA to identify amino acids essential for vacuolating cytotoxic activity.

scientific article

Reconstitution of Helicobacter pylori VacA toxin from purified components

scientific article

Role of connexin 43 in Helicobacter pylori VacA-induced cell death.

scientific article

Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

scientific article published on 30 June 2020

The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay

scientific article

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