List of works - Hanns-Ulrich Marschall

24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

scientific article published in February 2006

A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism—Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers

scientific article published in 2022

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

scientific article published in August 2016

A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis

scientific article

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

scientific article published on 19 July 2019

Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice

scientific article published on 06 March 2020

Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.

scientific article

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

scientific article

Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

scientific article published on 14 February 2019

Associations between Dietary Patterns and Bile Acids-Results from a Cross-Sectional Study in Vegans and Omnivores

scientific article published on 23 December 2019

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

scientific article published in August 2005

Characterization of animal models for primary sclerosing cholangitis (PSC).

scientific article published on 19 February 2014

Combined rifampicin and ursodeoxycholic acid treatment does not amplify rifampicin effects on hepatic detoxification and transport systems in humans

scientific article published on 5 September 2012

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans

scientific article published in August 2005

Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids

scientific article published on 15 December 2005

Cyp3a11 is not essential for the formation of murine bile acids

scientific article published on 8 March 2017

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

scientific article

Effects of Vedolizumab in Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Diseases

scientific article published on 14 May 2019

Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.

scientific article

Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis

scientific article published on 21 May 2019

Ensuring timely treatment of patients with primary biliary cholangitis

scientific article published on 13 July 2018

Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study

scientific article published on 26 September 2019

Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis

scientific article

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci

scientific article

Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids

scientific article published on 4 December 2005

Gallstone disease in Swedish twins is associated with the Gilbert variant of UGT1A1 ⬇️

scientific article published on March 20, 2013

Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4

scientific journal article

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

scientific article

Gut pathobionts as triggers for liver diseases

scientific article published on 01 March 2019

Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease

scientific article

Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic Constipation, Cholestatic Pruritus, and NASH

scientific article published on 21 August 2018

Incidence, prevalence, and outcome of primary biliary cholangitis in a nationwide Swedish population-based cohort

scientific article published on 08 August 2019

Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota

scientific article

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis

article

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

scientific article published on 14 March 2019

Intrahepatic Cholestasis of Pregnancy Levels of Sulfated Progesterone Metabolites Inhibit Farnesoid X Receptor Resulting in a Cholestatic Phenotype ⬇️

scientific article published on January 8, 2013

Intrahepatic cholestasis of pregnancy and associated hepatobiliary disease: a population-based cohort study

scientific article published on 6 August 2013

Life-threatening complications of nasogastric administration of polyethylene glycol-electrolyte solutions (Golytely) for bowel cleansing ⬇️

scientific article published on 01 May 1998

Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver

scientific article published on 19 December 2019

Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.

scientific article

Muscle performance and fatigue in compensated chronic liver disease

scientific article published on 09 July 2019

Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in mouse model of gestational diabetes

scientific article published on 25 June 2019

Obeticholic acid may increase the risk of gallstone formation in susceptible patients

scientific article published on 27 June 2019

Oncosis represents the main type of cell death in mouse models of cholestasis

scientific article published in March 2005

Outcomes of Pregnancy in Mothers With Cirrhosis: A National Population-Based Cohort Study of 1.3 Million Pregnancies

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.

scientific article published on 02 March 2017

Pilot study with IBAT inhibitor A4250 for the treatment of cholestatic pruritus in primary biliary cholangitis.

scientific article

Plasma Bile Acid Concentrations in Humans: Suggestions for Presentation in Tabular Form

Pregnancy Outcome in Women Undergoing Liver Biopsy During Pregnancy: A Nationwide Population-Based Cohort Study

scientific article

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

scientific article published on October 2015

Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans

scientific article published on 07 June 2019

Risks of emergency cesarean section and fetal asphyxia after induction of labor in intrahepatic cholestasis of pregnancy: a hospital-based retrospective cohort study.

scientific article published on 11 December 2012

Role of Bile Acids in Metabolic Control

scientific article published on 28 November 2017

STK25 is a critical determinant in nonalcoholic steatohepatitis

scientific article published on 15 July 2016

Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice

scientific article

Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy ⬇️

scientific article published on September 25, 2012

Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis

scientific article published in 2022

Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease

scientific article published on 19 December 2018

The 35-year odyssey of beta blockers in cirrhosis: any gender difference in sight?

scientific article published on 15 January 2017

The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation.

scientific article

The reversed feto-maternal bile acid gradient in intrahepatic cholestasis of pregnancy is corrected by ursodeoxycholic acid

scientific article published on 08 January 2014

Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action

scientific article published on 15 October 2018

Ursodeoxycholic acid for intrahepatic cholestasis in pregnancy

scientific article published on 01 August 2019

Ursodeoxycholic acid for treatment of fatty liver disease and dyslipidemia in morbidly obese patients

scientific article published on 17 June 2011

Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy

scientific article published on 25 June 2020

Ursodeoxycholic acid: effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients.

scientific article published on 29 August 2017

Validation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis

scientific article published on 01 July 2019

When Bile Acids Don't Get Amidated ⬇️

scientific article published on March 22, 2013

List of works by Hanns-Ulrich Marschall

24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism—Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice

Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

Associations between Dietary Patterns and Bile Acids-Results from a Cross-Sectional Study in Vegans and Omnivores

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

Characterization of animal models for primary sclerosing cholangitis (PSC).

Combined rifampicin and ursodeoxycholic acid treatment does not amplify rifampicin effects on hepatic detoxification and transport systems in humans

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans

Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids

Cyp3a11 is not essential for the formation of murine bile acids

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Effects of Vedolizumab in Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Diseases

Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.

Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis

Ensuring timely treatment of patients with primary biliary cholangitis

Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study

Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci

Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids

Gallstone disease in Swedish twins is associated with the Gilbert variant of UGT1A1 ⬇️

Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

Gut pathobionts as triggers for liver diseases

Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease

Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic Constipation, Cholestatic Pruritus, and NASH

Incidence, prevalence, and outcome of primary biliary cholangitis in a nationwide Swedish population-based cohort

Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

Intrahepatic Cholestasis of Pregnancy Levels of Sulfated Progesterone Metabolites Inhibit Farnesoid X Receptor Resulting in a Cholestatic Phenotype ⬇️

Intrahepatic cholestasis of pregnancy and associated hepatobiliary disease: a population-based cohort study

Life-threatening complications of nasogastric administration of polyethylene glycol-electrolyte solutions (Golytely) for bowel cleansing ⬇️

Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver

Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.

Muscle performance and fatigue in compensated chronic liver disease

Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in mouse model of gestational diabetes

Obeticholic acid may increase the risk of gallstone formation in susceptible patients

Oncosis represents the main type of cell death in mouse models of cholestasis

Outcomes of Pregnancy in Mothers With Cirrhosis: A National Population-Based Cohort Study of 1.3 Million Pregnancies

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.

Pilot study with IBAT inhibitor A4250 for the treatment of cholestatic pruritus in primary biliary cholangitis.

Plasma Bile Acid Concentrations in Humans: Suggestions for Presentation in Tabular Form

Pregnancy Outcome in Women Undergoing Liver Biopsy During Pregnancy: A Nationwide Population-Based Cohort Study

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans

Risks of emergency cesarean section and fetal asphyxia after induction of labor in intrahepatic cholestasis of pregnancy: a hospital-based retrospective cohort study.

Role of Bile Acids in Metabolic Control

STK25 is a critical determinant in nonalcoholic steatohepatitis

Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice

Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy ⬇️

Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis

Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease

The 35-year odyssey of beta blockers in cirrhosis: any gender difference in sight?

The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation.

The reversed feto-maternal bile acid gradient in intrahepatic cholestasis of pregnancy is corrected by ursodeoxycholic acid

Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action

Ursodeoxycholic acid for intrahepatic cholestasis in pregnancy

Ursodeoxycholic acid for treatment of fatty liver disease and dyslipidemia in morbidly obese patients

Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy

Ursodeoxycholic acid: effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients.

Validation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis

When Bile Acids Don't Get Amidated ⬇️