List of works - Heather Mortiboys

A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA.

scientific article published on 18 July 2015

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio).

scientific article

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations.

scientific article published on 14 December 2016

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

scientific article

IHG-1 increases mitochondrial fusion and bioenergetic function.

scientific article published on 9 July 2014

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1-/- zebrafish

scientific article

Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies

scientific article

Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

scientific article published on 27 July 2018

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

scientific article published on 19 July 2018

Mitochondrial dysfunction in Parkinson's disease--revisited.

scientific article published on March 2007

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

scientific article

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

scientific article published on November 2010

Modulating mitophagy in mitochondrial disease.

scientific article published on 16 June 2017

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

scientific article

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

scientific article published on 16 August 2009

Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes

scientific article published on 10 July 2016

Screening for chemical modulators for LRRK2.

scientific article published on December 2016

Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis

scientific article published on 3 December 2013

TIGAR inclusion pathology is specific for Lewy body diseases

scientific article published on 26 September 2018

The common PARK8 mutation LRRK2G²⁰¹⁹S is not a risk factor for breast cancer in the absence of Parkinson's disease

scientific article published on 4 July 2013

The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy

scientific article

The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type.

scientific article

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

scientific article published on December 2013

Translational approaches to restoring mitochondrial function in Parkinson's disease.

scientific article published on 27 November 2017

UDCA exerts beneficial effect on mitochondrial dysfunction in LRRK2(G2019S) carriers and in vivo.

scientific article

USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation

scientific article published on 07 July 2020

Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease

scientific article

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease

scientific article published on 29 August 2018

List of works by Heather Mortiboys

A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA.

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio).

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations.

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

IHG-1 increases mitochondrial fusion and bioenergetic function.

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1-/- zebrafish

Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies

Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Mitochondrial dysfunction in Parkinson's disease--revisited.

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

Modulating mitophagy in mitochondrial disease.

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes

Screening for chemical modulators for LRRK2.

Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis

TIGAR inclusion pathology is specific for Lewy body diseases

The common PARK8 mutation LRRK2G²⁰¹⁹S is not a risk factor for breast cancer in the absence of Parkinson's disease

The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy

The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type.

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

Translational approaches to restoring mitochondrial function in Parkinson's disease.

UDCA exerts beneficial effect on mitochondrial dysfunction in LRRK2(G2019S) carriers and in vivo.

USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation

Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease