List of works - Aashish Manglik

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

scientific article

A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins.

scientific article

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins

scientific article

Activation and allosteric modulation of a muscarinic acetylcholine receptor

scientific article

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

scientific article

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

scientific article published on 13 July 2016

An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation

scientific article published on 10 August 2020

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

scientific article published on 05 November 2020

Applications of molecular replacement to G protein-coupled receptors

scientific article published on 18 October 2013

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization

scientific article published on 15 July 2020

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

scientific article published on 15 October 2020

Covalent agonists for studying G protein-coupled receptor activation

scientific article

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

scientific article

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

scientific article

Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

scientific article published on 27 August 2020

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).

scientific article published on 13 March 2015

Goniometer-based femtosecond crystallography with X-ray free electron lasers

scientific article

Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit

scientific article published on 02 November 2020

High-density grids for efficient data collection from multiple crystals

scientific article

Nanobodies to Study G Protein-Coupled Receptor Structure and Function

scientific article

Propagation of conformational changes during μ-opioid receptor activation

scientific article published on 5 August 2015

Protein design and variant prediction using autoregressive generative models

scientific article published on 23 April 2021

Role of detergents in conformational exchange of a G protein-coupled receptor

scientific article

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins

scientific article

Selective G protein signaling driven by substance P-neurokinin receptor dynamics

scientific article published on 28 October 2021

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling

scientific article published on 26 March 2018

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

scientific article published on 14 May 2015

Structural basis of odorant recognition by a human odorant receptor ⬇️

Structural insights into µ-opioid receptor activation

scientific article

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

scientific article

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

scientific article published on 19 August 2020

Structure of the δ-opioid receptor bound to naltrindole

scientific article

Structure-based discovery of opioid analgesics with reduced side effects

scientific article

The dynamic process of β(2)-adrenergic receptor activation

scientific article published on January 2013

The role of ligands on the equilibria between functional states of a G protein-coupled receptor

scientific article published on 14 June 2013

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

scientific article published on 17 February 2014

Yeast surface display platform for rapid discovery of conformationally selective nanobodies.

scientific article published on 12 February 2018

List of works by Aashish Manglik

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins.

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

Applications of molecular replacement to G protein-coupled receptors

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Covalent agonists for studying G protein-coupled receptor activation

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).

Goniometer-based femtosecond crystallography with X-ray free electron lasers

Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit

High-density grids for efficient data collection from multiple crystals

Nanobodies to Study G Protein-Coupled Receptor Structure and Function

Propagation of conformational changes during μ-opioid receptor activation

Protein design and variant prediction using autoregressive generative models

Role of detergents in conformational exchange of a G protein-coupled receptor

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins

Selective G protein signaling driven by substance P-neurokinin receptor dynamics

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

Structural basis of odorant recognition by a human odorant receptor ⬇️

Structural insights into µ-opioid receptor activation

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Structure of the δ-opioid receptor bound to naltrindole

Structure-based discovery of opioid analgesics with reduced side effects

The dynamic process of β(2)-adrenergic receptor activation

The role of ligands on the equilibria between functional states of a G protein-coupled receptor

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

Yeast surface display platform for rapid discovery of conformationally selective nanobodies.