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List of works by Orit Rozenblatt-Rosen

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

article

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

scientific article published on 23 May 2019

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

scientific article published on September 2016

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

scientific article published in November 2017

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

scientific article published on 25 July 2020

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

scientific article published in Nature

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors

scientific article published on 11 May 2020

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

article published in 2021

A single-cell landscape of high-grade serous ovarian cancer

scientific article published on 22 June 2020

A single-cell survey of the small intestinal epithelium

scientific article published on 8 November 2017

Acquired FGFR and FGF alterations confer resistance to estrogen receptor (ER) targeted therapy in ER+ metastatic breast cancer

scientific article published on 28 July 2020

Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor-directed therapies

scientific article published on 10 December 2018

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

scientific article published on 01 November 2020

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

scientific article published on 18 July 2019

An integrated cell atlas of the lung in health and disease

Author Correction: A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors

scientific article published on 25 June 2020

Author Correction: Nuclei multiplexing with barcoded antibodies for single-nucleus genomics

scientific article published on 02 November 2020

Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

scientific article published on 27 April 2020

Blood and immune development in human fetal bone marrow and Down syndrome

scientific article published on 29 September 2021

Building a high-quality Human Cell Atlas ⬇️

journal article from 'Nature Biotechnology' published in 2021

CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq

scientific article published on 28 April 2016

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells

scientific article published on 08 January 2019

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

scientific article published on April 2016

Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq

scientific article published on 27 July 2020

Decoding human fetal liver haematopoiesis

scientific article published on 09 October 2019

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.

scientific article published on March 2017

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

scientific article published in April 2018

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

scientific article published on April 2016

Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

scientific article published on 01 September 2020

Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

scientific article published on 15 November 2017

IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development

scientific article published on 01 December 2019

Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor

scientific article

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

scientific article published in Nature

Induction of chondrocyte growth arrest by FGF: transcriptional and cytoskeletal alterations

scientific article

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes

scientific article published on 13 April 2020

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

scientific journal article

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

scientific article published on 01 July 2019

Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair-Deficient Colorectal Cancer

scientific article published on 19 June 2019

Kidney organoid reproducibility across multiple human iPSC lines and diminished off target cells after transplantation revealed by single cell transcriptomics: Supplemental Tables

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

scientific article published on 28 February 2019

Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression

Massively parallel single-nucleus RNA-seq with DroNc-seq

scientific article published on 28 August 2017

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

scientific article

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

scientific article

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

scientific journal article

Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities

scientific article published on 20 March 2013

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

scientific article published on 19 August 2019

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

scientific article published on 27 August 2020

National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions

scientific article published on 02 April 2020

Nuclei multiplexing with barcoded antibodies for single-nucleus genomics

scientific article published on 02 July 2019

Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.

scientific article

Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma

scientific article published on 25 January 2021

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

scientific article published on 30 October 2020

Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583

scientific article published on 01 October 2006

Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity

scientific article published on 05 September 2018

Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells

scientific article published on 10 April 2014

Resolving medulloblastoma cellular architecture by single-cell genomics

scientific article published on 24 July 2019

SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver

scientific article published on July 2011

SM-Omics is an automated platform for high-throughput spatial multi-omics

scientific article published on 10 February 2022

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas ⬇️

scientific article

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

scholarly article

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors ⬇️

journal article from 'bioRxiv' published in 2020

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

scientific article published on 01 July 2020

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

scientific article

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

scientific article

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

scientific article

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

scientific article published on 2 November 2016

Single-cell transcriptomics to explore the immune system in health and disease

scientific article

Streamlined Protocol for Deep Proteomic Profiling of FAC-sorted Cells and Its Application to Freshly Isolated Murine Immune Cells

scientific article published on 21 February 2019

Systematic benchmarking of single-cell ATAC-sequencing protocols

scientific article published in 2023

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

scientific article published on 06 April 2020

T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity

scientific article published on 09 November 2020

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

scientific article published on 01 November 2018

TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

scientific article published on 09 June 2021

The Human Cell Atlas

scientific article

The Human Cell Atlas

The Human Cell Atlas White Paper ⬇️

journal article from 'arXiv:1810.05192 [q-bio]' published in 2018

The Human Cell Atlas: from vision to reality

scientific article published in October 2017

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

scientific article published on 01 April 2020

The Human and Mouse Enteric Nervous System at Single-Cell Resolution

scientific article published on 21 August 2020

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

scientific article published on 28 March 2019

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

scientific article published on October 2005

The menin tumor suppressor protein is phosphorylated in response to DNA damage

scientific article

The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination

scientific article

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

scientific article published on 13 September 2017

The parafibromin tumor suppressor protein is part of a human Paf1 complex

scientific article

The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors

scientific article

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

scientific article published on 01 October 2019

Transcriptional activators enhance polyadenylation of mRNA precursors

scientific article

Transcriptional mediators of treatment resistance in lethal prostate cancer

scientific article published on 04 March 2021

Viral perturbations of host networks reflect disease etiology

scientific article

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