List of works - Mark W Irvine

A novel family of negative and positive allosteric modulators of NMDA receptors.

scientific article

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.

scientific article published on 31 July 2017

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo.

scientific article

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-d-aspartate receptors ⬇️

scientific article published on January 13, 2012

Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.

scientific article

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid

scientific article published on 28 December 2018

Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.

scientific article published on 11 July 2017

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

scientific article published on 11 August 2016

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

scientific article published on 17 January 2012

Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors

scientific article published on 14 December 2011

Positive and Negative Allosteric Modulators of N-Methyl-D-Aspartate (NMDA) Receptors; Structure-Activity Relationships and Mechanisms of Action.

scientific article published on 15 February 2018

Rhodanine derivatives as novel inhibitors of PDE4.

scientific article

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

scientific article published on 22 January 2020

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid.

scientific article published on 6 December 2011

Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators.

scientific article

The NMDA receptor as a target for cognitive enhancement

scientific article

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators

scientific article published on 29 November 2018

The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site

scientific article published on 7 February 2017

List of works by Mark W Irvine

A novel family of negative and positive allosteric modulators of NMDA receptors.

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo.

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-d-aspartate receptors ⬇️

Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid

Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors

Positive and Negative Allosteric Modulators of N-Methyl-D-Aspartate (NMDA) Receptors; Structure-Activity Relationships and Mechanisms of Action.

Rhodanine derivatives as novel inhibitors of PDE4.

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid.

Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators.

The NMDA receptor as a target for cognitive enhancement

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators

The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site