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List of works by David Leach

A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex

scientific article

A perfect palindrome in the Escherichia coli chromosome forms DNA hairpins on both leading- and lagging-strands

scientific article

Bacterial genome instability

scientific article (publication date: March 2014)

Branch migration prevents DNA loss during double-strand break repair

scientific article

Broken replication forks trigger heritable DNA breaks in the terminus of a circular chromosome

scientific article published on 9 March 2018

Chemical Evolution of a Bacterial Proteome

scientific article published on July 2015

Chromosomal directionality of DNA mismatch repair in Escherichia coli

scientific article published on 13 July 2015

Cloning and sequencing of four structural genes for the Na(+)-translocating NADH-ubiquinone oxidoreductase of Vibrio alginolyticus.

scientific article

DIR: a novel DNA rearrangement associated with inverted repeats.

scientific article published on February 1997

DNA double strand break repair in Escherichia coli perturbs cell division and chromosome dynamics

scientific article published on 02 January 2020

DNA palindromes adopt a methylation-resistant conformation that is consistent with DNA cruciform or hairpin formation in vivo.

scientific article

DNA tandem repeat instability in the Escherichia coli chromosome is stimulated by mismatch repair at an adjacent CAG·CTG trinucleotide repeat

scientific article

DNA targeting and interference by a bacterial Argonaute nuclease

scientific article published on 30 July 2020

Different structures of selected and unselected araB–lacZ fusions

scientific article published on 01 March 1997

Distribution of Holliday junctions and repair forks during Escherichia coli DNA double-strand break repair

scientific article published on 25 August 2021

Division-induced DNA double strand breaks in the chromosome terminus region of Escherichia coli lacking RecBCD DNA repair enzyme

scientific article

Dynamics of RecA-mediated repair of replication-dependent DNA breaks

scholarly article

E. coli SbcCD and RecA control chromosomal rearrangement induced by an interrupted palindrome.

scientific article published in July 2010

Evidence for two preferred hairpin folding patterns in d(CGG)·d(CCG) repeat tracts in vivo 1 1Edited by I. Tinoco

article

Expansion of CAG repeats in Escherichia coli is controlled by single-strand DNA exonucleases of both polarities.

scientific article published on 31 July 2014

Holliday junctions, heteroduplex DNA and map expansion: a commentary on ‘A mechanism for gene conversion in fungi’ by Robin Holliday

article

Inside Cover: Chemical Evolution of a Bacterial Proteome (Angew. Chem. Int. Ed. 34/2015)

Long inverted repeat transiently stalls DNA replication by forming hairpin structures on both leading and lagging strands

scientific article published on 6 January 2016

Mini-Mu mediates deletion-inversions in vivo by intra-transposon transposition

scientific article published on 01 April 1990

Non-random segregation of sister chromosomes in Escherichia coli.

scientific article published in October 2008

Nucleolytic processing of a protein-bound DNA end by the E. coli SbcCD (MR) complex.

scientific article

Overexpression of the single-stranded DNA-binding protein (SSB) stabilises CAG*CTG triplet repeats in an orientation dependent manner.

scientific article published in January 2010

Overexpression, purification, and characterization of the SbcCD protein from Escherichia coli.

scientific article published in August 1997

Prevent and Cure: RPA Cooperates with Mre11-Sae2 in DNA Secondary Structure Repair.

scientific article published in November 2015

Pulsed-field gel electrophoresis of bacterial chromosomes.

scientific article

Quantitative genomic analysis of RecA protein binding during DNA double-strand break repair reveals RecBCD action in vivo

scientific article

RecBCD coordinates repair of two ends at a DNA double-strand break, preventing aberrant chromosome amplification

scientific article published on 01 July 2018

RecG Directs DNA Synthesis during Double-Strand Break Repair.

scientific article published on 12 February 2016

RecG controls DNA amplification at double-strand breaks and arrested replication forks

scientific article published on 2 February 2017

Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans.

scientific article

Repair by recombination of DNA containing a palindromic sequence

scientific article published on November 1, 1997

Repair of DNA covalently linked to protein.

scientific article published on February 2004

Repair on the go: E. coli maintains a high proliferation rate while repairing a chronic DNA double-strand break

scientific article

Replication Fork Breakage and Restart in Escherichia coli

scientific article published on 13 June 2018

Replication strand preference for deletions associated with DNA palindromes

scientific article published on 01 May 1998

Resolution of joint molecules by RuvABC and RecG following cleavage of the Escherichia coli chromosome by EcoKI

scientific article

SbcCD causes a double-strand break at a DNA palindrome in the Escherichia coli chromosome.

scientific article

SbcCD regulation and localization in Escherichia coli.

scientific article published on 20 July 2007

Sequence interruptions in enterobacterial repeated elements retain their ability to encode well‐folded RNA secondary structures

scientific article published on 01 June 1997

Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast.

scientific article

The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA

scientific article published on July 7, 1998

The SbcCD protein of Escherichia coli is related to two putative nucleases in the UvrA superfamily of nucleotide-binding proteins.

scientific article

The isolation and characterisation of a plaque-forming derivative of bacteriophage Mu carrying a fragment of Tn3 conferring ampicillin resistance

scientific article published on May 4, 1979

The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination.

scientific article

Two opposing effects of mismatch repair on CTG repeat instability in Escherichia coli

scientific article published on 01 January 2000

Viability of λ phages carrying a perfect palindrome in the absence of recombination nucleases

scientific article published on October 29, 1983