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List of works by Robert P Giugliano

2004 ACC/AHA guideline for the management of patients with STEMI: the implications for clinicians

scientific article published on 01 March 2005

A Randomized, Blinded Study of Two Doses of Novastan(R) (Brand of Argatroban) Versus Heparin as Adjunctive Therapy to Recombinant Tissue Plasminogen Activator (Accelerated Administration) in Acute Myocardial Infarction: Rationale and Design of the M

scientific article published on 01 January 1998

A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study

scientific article published on 01 June 1999

A novel approach indirectly comparing benefit-risk balance across anti-thrombotic therapies in patients with atrial fibrillation

scientific article published on 01 January 2015

A novel risk prediction score in atrial fibrillation for a net clinical outcome from the ENGAGE AF-TIMI 48 randomized clinical trial

scientific article published on 6 January 2017

A polygenic risk score predicts atrial fibrillation in cardiovascular disease

scientific article published in 2022

A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disease morbidity and mortality

scientific article

A simple risk index for rapid initial triage of patients with ST-elevation myocardial infarction: an InTIME II substudy ⬇️

scientific article published on November 10, 2001

A strategy of using enoxaparin as adjunctive antithrombin therapy reduces death and recurrent myocardial infarction in patients who achieve early ST-segment resolution after fibrinolytic therapy: the ExTRACT-TIMI 25 ECG study

scientific article published on 28 June 2007

AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of national cholesterol education program-adult treatment panel III low-density lipoprotein cholesterol goals among high-risk patients: an analysis from the LAPLACE-TIMI 57 trial

scientific article published on 23 October 2013

AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C Assessment with Proprotein Convertase Sub

scientific article published on 24 July 2013

Abciximab facilitates the rate and extent of thrombolysis: results of the thrombolysis in myocardial infarction (TIMI) 14 trial. The TIMI 14 Investigators

scientific article published on 01 June 1999

Abciximab improves both epicardial flow and myocardial reperfusion in ST-elevation myocardial infarction. Observations from the TIMI 14 trial

scientific article published on 01 January 2000

Achievement of dual low-density lipoprotein cholesterol and high-sensitivity C-reactive protein targets more frequent with the addition of ezetimibe to simvastatin and associated with better outcomes in IMPROVE-IT.

scientific article published on September 2015

Achievement of guideline-concordant care and in-hospital outcomes in patients with coronary artery disease in teaching and nonteaching hospitals: results from the Get With The Guidelines-Coronary Artery Disease program

scientific article

Adjunctive pharmacologic therapy in percutaneous coronary intervention: part I antiplatelet therapy.

scientific article published on March 2011

Adjunctive pharmacologic therapy in percutaneous coronary intervention: part II anticoagulant therapy.

scientific article published on March 2011

Adjunctive use of anticoagulants at the time of percutaneous coronary intervention in patients with an acute coronary syndrome treated with fondaparinux: a multinational retrospective review.

scientific article

Advances in the field of proprotein convertase subtilisin kexin type 9 inhibitors.

scientific article published on 22 September 2016

Age, treatment, and outcomes in high-risk non-ST-segment elevation acute coronary syndrome patients: insights from the EARLY ACS trial

scientific article published on 13 July 2012

An update on the IMProved reduction of outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design

scientific article published on 15 March 2010

Angiographic and clinical outcomes among patients with acute coronary syndromes presenting with isolated anterior ST-segment depression: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Pra

scientific article published on August 2010

Angiographic and clinical outcomes associated with direct versus conventional stenting among patients treated with fibrinolytic therapy for ST-elevation acute myocardial infarction

scientific article published in February 2005

Angiographic outcomes with early eptifibatide therapy in non-ST-segment elevation acute coronary syndrome (from the EARLY ACS Trial).

scientific article

Angiographic perfusion score: an angiographic variable that integrates both epicardial and tissue level perfusion before and after facilitated percutaneous coronary intervention in acute myocardial infarction

scientific article

Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome

scientific article published on April 2005

Anticoagulation After Heart Valve Replacement or Transcatheter Valve Implantation.

scientific article published on 13 August 2016

Anticoagulation-related nephropathy

scientific article published on 16 December 2015

Antiplatelet and Anticoagulation Treatment in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome: Comparison of the Updated North American and European Guidelines

scientific article published on 16 July 2015

Antiplatelet therapy in percutaneous coronary intervention: integration of prasugrel into clinical practice.

scientific article published on March 2009

Antithrombotics in acute coronary syndromes

scientific article published on September 2009

Antithrombotics in acute coronary syndromes: updates from the past year.

scientific article published on January 2010

Are PCSK9 Inhibitors the Next Breakthrough in the Cardiovascular Field?

scientific article

Association Between Circulating Baseline Proprotein Convertase Subtilisin Kexin Type 9 Levels and Efficacy of Evolocumab

scientific article published on 25 January 2017

Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis

scientific article published on September 2016

Association between angiographic complications and clinical outcomes among patients with acute coronary syndrome undergoing percutaneous coronary intervention: an EARLY ACS (Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment Elevation Acute Co

scientific article published on 01 September 2012

Association between bleeding and mortality among women and men with high-risk acute coronary syndromes: insights from the Early versus Delayed, Provisional Eptifibatide in Acute Coronary Syndromes (EARLY ACS) trial

scientific article published on 5 September 2013

Association between edoxaban dose, concentration, anti-Factor Xa activity, and outcomes: an analysis of data from the randomised, double-blind ENGAGE AF-TIMI 48 trial

scientific article

Association of a history of systemic hypertension with mortality, thrombotic, and bleeding complications following non-ST-segment elevation acute coronary syndrome

scientific article published on 01 May 2006

Association of a negative residual stenosis following rescue/adjunctive percutaneous coronary intervention with impaired myocardial perfusion and adverse outcomes among ST-segment elevation myocardial infarction patients

scientific article

Association of a pulsatile blood flow pattern on coronary arteriography and short-term clinical outcomes in acute myocardial infarction

scientific article published in April 2004

Association of creatinine and creatinine clearance on presentation in acute myocardial infarction with subsequent mortality

scientific article

Association of culprit lesion calcium with angiographic and clinical outcomes in patients with ST-elevation myocardial infarction treated with fibrinolytic therapy

scientific article published on 01 February 2005

Association of duration of symptoms at presentation with angiographic and clinical outcomes after fibrinolytic therapy in patients with ST-segment elevation myocardial infarction

scientific article published on 01 September 2004

Association of epicardial and tissue-level reperfusion with left ventricular end-diastolic pressures in ST-elevation myocardial infarction

scientific article published on 01 June 2004

Association of glomerular filtration rate on presentation with subsequent mortality in non-ST-segment elevation acute coronary syndrome; observations in 13,307 patients in five TIMI trials

scientific article published on 01 November 2004

Association of hemoglobin levels with clinical outcomes in acute coronary syndromes

scientific article published on 11 April 2005

Association of metabolic syndrome and its individual components with outcomes among patients with high-risk non-ST-segment elevation acute coronary syndromes

scientific article published on 24 April 2014

Association of platelet count with residual thrombus in the myocardial infarct-related coronary artery among patients treated with fibrinolytic therapy for ST-segment elevation acute myocardial infarction

scientific article

Association of smoking with improved myocardial perfusion and the angiographic characterization of myocardial tissue perfusion after fibrinolytic therapy for ST-segment elevation myocardial infarction

scientific article published on 01 January 2005

Association of the timing of ST-segment resolution with TIMI myocardial perfusion grade in acute myocardial infarction

scientific article

Association of unstable angina guideline care with improved survival.

scientific article published in June 2000

Atherothrombotic Risk Stratification and Ezetimibe for Secondary Prevention

scientific article published in February 2017

Atrial Fibrillation, Type 2 Diabetes, and Non-Vitamin K Antagonist Oral Anticoagulants: A Review.

scientific article published on 25 January 2017

Atrial fibrillation and prior MI: searching for balance in ischaemic and bleeding events in patients treated with factor-specific anticoagulants.

scientific article published on 25 November 2013

Atrial fibrillation and the 'other drug problem': reducing non-adherence with technology.

scientific article published on 22 May 2013

Availability of on-site catheterization and clinical outcomes in patients receiving fibrinolysis for ST-elevation myocardial infarction

scientific article published on 01 November 2001

Baseline low-density lipoprotein cholesterol is an important predictor of the benefit of intensive lipid-lowering therapy: a PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) ana

scientific article

Baseline troponin in acute coronary syndromes managed invasively

scientific article published on 01 December 2004

Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus: Results From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).

scientific article published on 20 December 2017

Biomarkers and Clinical Cardiovascular Outcomes With Ezetimibe in the IMPROVE-IT Trial

scientific article published on 01 August 2019

Bridging therapy after recent stent implantation: case report and review of data.

scientific article

Caeteris paribus - all things being equal

scientific article published on 01 December 2001

Can we predict outcomes in atrial fibrillation?

scientific article published on January 2012

Cardiac troponin after percutaneous coronary intervention and 1-year mortality in non-ST-segment elevation acute coronary syndrome using systematic evaluation of biomarker trends

scientific article published on 15 May 2013

Cardiovascular Biomarker Score and Clinical Outcomes in Patients With Atrial Fibrillation: A Subanalysis of the ENGAGE AF-TIMI 48 Randomized Clinical Trial

scientific article published on 05 October 2016

Cardiovascular Risk Reduction in Patients with Nonalcoholic Fatty Liver Disease: The Potential Role of Ezetimibe.

scientific article

Cardiovascular safety and efficacy of the PCSK9 inhibitor evolocumab in patients with and without diabetes and the effect of evolocumab on glycaemia and risk of new-onset diabetes: a prespecified analysis of the FOURIER randomised controlled trial.

scientific article published on 14 September 2017

Cardioversion of Atrial Fibrillation in ENGAGE AF-TIMI 48.

scientific article published on 30 March 2016

Care concordant with guidelines predicts decreased long-term mortality in patients with unstable angina pectoris and non-ST-elevation myocardial infarction.

scientific article

Cerebrovascular events in 21 105 patients with atrial fibrillation randomized to edoxaban versus warfarin: Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48.

scientific article published on 19 June 2014

Cholesterol levels and the association of statins with in-hospital mortality of myocardial infarction patients insights from a Chilean registry of myocardial infarction.

scientific article

Chronic anticoagulation in non-valvular atrial fibrillation: Where things stand

scientific article published on 3 August 2016

Circadian variation in patient characteristics and outcomes in ST-segment elevation myocardial infarction

scientific article published on 06 November 2012

Circadian variation of stent thrombosis and the effect of more robust platelet inhibition: a post hoc analysis of the TRITON-TIMI 38 trial

scientific article published on 24 September 2013

Clinical Application of a Novel Genetic Risk Score for Ischemic Stroke in Patients with Cardiometabolic Disease

scientific article published on 13 November 2020

Clinical Benefit of Evolocumab by Severity and Extent of Coronary Artery Disease: Analysis From FOURIER

scientific article published on 01 August 2018

Clinical Efficacy and Safety of Evolocumab in High-Risk Patients Receiving a Statin: Secondary Analysis of Patients With Low LDL Cholesterol Levels and in Those Already Receiving a Maximal-Potency Statin in a Randomized Clinical Trial.

scientific article published on 8 November 2017

Clinical benefits of evolocumab appear less than hoped - Authors' reply

scientific article published on 01 March 2018

Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial.

scientific article published on 25 August 2017

Clinical events after interruption of anticoagulation in patients with atrial fibrillation: An analysis from the ENGAGE AF-TIMI 48 trial

scientific article published on 26 January 2018

Clinical implications and correlates of Q waves in patients with ST-elevation myocardial infarction treated with fibrinolysis: observations from the CLARITY-TIMI 28 trial.

scientific article

Clinical problem-solving. When past is prologue.

scientific article published in March 2009

Cognitive Function in a Randomized Trial of Evolocumab

scientific article published in August 2017

Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14. The Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators

scientific article published on 01 December 2000

Combination reperfusion therapy with eptifibatide and reduced-dose tenecteplase for ST-elevation myocardial infarction: results of the integrilin and tenecteplase in acute myocardial infarction (INTEGRITI) Phase II Angiographic Trial

scientific article (publication date: 16 April 2003)

Combined assessment of thrombolysis in myocardial infarction flow grade, myocardial perfusion grade, and ST-segment resolution to evaluate epicardial and myocardial reperfusion

scientific article

Comparison of Argatroban and Hirudin for the Reperfusion of Thrombotic Arterial Occlusion by Tissue Plasminogen Activator

scientific article published on 01 September 1998

Comparison of LDL-C Reduction Using Different Evolocumab Doses and Intervals: Biological Insights and Treatment Implications

scientific article published on 16 May 2018

Comparison of Low-Density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation: Insights From the FOURIER Trial.

scientific article published in August 2018

Comparison of ST-segment resolution with combined fibrinolytic and glycoprotein IIb/IIIa inhibitor therapy versus fibrinolytic alone (data from four clinical trials).

scientific article

Comparison of a 60- versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction. In TIME-II Investigators. Intravenous nPA for Treatment of Infarcting Myocardium Early-II

scientific article published on 01 December 2000

Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials

scientific article published on 4 December 2013

Comparison of the phase III clinical trial designs of novel oral anticoagulants versus warfarin for the treatment of nonvalvular atrial fibrillation: implications for clinical practice.

scientific article published on April 2014

Comparison of the prognosis of spontaneous and percutaneous coronary intervention-related myocardial infarction.

scientific article

Competing Risks of Cardiovascular Versus Noncardiovascular Death During Long-Term Follow-Up After Acute Coronary Syndromes

scientific article published on 18 September 2017

Complementary prognostic values of ST segment deviation and Thrombolysis In Myocardial Infarction (TIMI) risk score in non-ST elevation acute coronary syndromes: Insights from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patie

scientific article

Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF-TIMI48 Trial

scientific article published on 23 February 2016

Coronary artery stents: advances in technology.

scientific article

Cost-Effectiveness of Edoxaban vs. Warfarin in Patients with Atrial Fibrillation Based on Results of the ENGAGE AF - TIMI 48 Trial: Taiwanese Perspective

scientific article published on 17 May 2017

Cost-effectiveness of Evolocumab Therapy for Reducing Cardiovascular Events in Patients With Atherosclerotic Cardiovascular Disease.

scientific article

Cost-effectiveness of edoxaban vs warfarin in patients with atrial fibrillation based on results of the ENGAGE AF-TIMI 48 trial

scientific article published on 25 September 2015

Current and developing strategies for monitoring and reversing direct oral anticoagulants in patients with non-valvular atrial fibrillation.

scientific article

Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients.

scientific article published on 05 September 2013

Dabigatran: a review of clinical and pharmacoeconomic evidence.

scientific article published on September 2011

Day 1 care in patients with non-ST-segment elevation myocardial infarction.

scientific article published on January 2010

Degree of residual stenosis in the culprit coronary artery after thrombolytic administration (Thrombolysis In Myocardial Infarction [TIMI] trials)

scientific article published on 01 June 2000

Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin bac

scientific article published on 16 February 2017

Design and rationale of the LAPLACE-TIMI 57 trial: a phase II, double-blind, placebo-controlled study of the efficacy and tolerability of a monoclonal antibody inhibitor of PCSK9 in subjects with hypercholesterolemia on background statin therapy

scientific article

Determinants of improvement in epicardial flow and myocardial perfusion for ST elevation myocardial infarction; insights from TIMI 14 and InTIME-II

scientific article published on 01 June 2002

Differential expression of cardiac biomarkers by gender in patients with unstable angina/non-ST-elevation myocardial infarction: a TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-T

scientific article published in February 2004

Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure in the ENGAGE AF-TIMI 48 Trial

scientific article

Does it Make Sense to Combine Statins with Other Lipid-Altering Agents Following AIM-HIGH, SHARP and ACCORD? ⬇️

scientific article published on January 1, 2013

Drug Class, Renal Elimination, and Outcomes of Direct Oral Anticoagulants in Asian Patients: A Meta-Analysis.

scientific article

Drug Interaction Between Clopidogrel and Ranitidine or Omeprazole in Stable Coronary Artery Disease: A Double-Blind, Double Dummy, Randomized Study

scientific article published on 01 August 2016

ED to catheterization laboratory: a roundtable integrating trials with practice ⬇️

scientific article published on October 23, 2010

EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention

scientific article

Early and long-term clinical outcomes associated with reinfarction following fibrinolytic administration in the Thrombolysis in Myocardial Infarction trials

scientific article published in July 2003

Early coronary intervention following pharmacologic therapy for acute myocardial infarction (the combined TIMI 10B-TIMI 14 experience)

scientific article published on 01 October 2001

Early noninvasive detection of failed epicardial reperfusion after fibrinolytic therapy

scientific article published on 01 August 2001

Early versus delayed, provisional eptifibatide in acute coronary syndromes

scientific article

Edoxaban Versus Warfarin in Atrial Fibrillation Patients at Risk of Falling: ENGAGE AF-TIMI 48 Analysis

scientific article published on September 2016

Edoxaban Versus Warfarin in Latin American Patients With Atrial Fibrillation: The ENGAGE AF-TIMI 48 Trial

scientific article published on 01 September 2018

Edoxaban or standard therapy with warfarin for stroke prevention in patients with atrial fibrillation?

scientific article published in March 2014

Edoxaban vs warfarin in patients with nonvalvular atrial fibrillation in the US Food and Drug Administration approval population: An analysis from the Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in My

scientific article

Edoxaban vs. Warfarin in East Asian Patients With Atrial Fibrillation　- An ENGAGE AF-TIMI 48 Subanalysis

scientific article

Edoxaban vs. warfarin in vitamin K antagonist experienced and naive patients with atrial fibrillation†

scientific article published on 16 February 2015

Edoxaban: Review of pharmacology and key phase I to III clinical trials.

scientific article published on 07 March 2014

Edoxaban: pharmacological principles, preclinical and early-phase clinical testing.

scientific article published on July 2011

Effect of Simvastatin-Ezetimibe Compared With Simvastatin Monotherapy After Acute Coronary Syndrome Among Patients 75 Years or Older: A Secondary Analysis of a Randomized Clinical Trial

scientific article published on 17 July 2019

Effect of rescue or adjunctive percutaneous coronary intervention of the culprit artery after fibrinolytic administration on epicardial flow in nonculprit arteries

scientific article published in July 2004

Effectiveness and safety of percutaneous coronary intervention after fibrinolytic therapy for ST-segment elevation acute myocardial infarction.

scientific article published on 20 January 2011

Effects of Regional Differences in Asia on Efficacy and Safety of Edoxaban Compared With Warfarin--Insights From the ENGAGE AF-TIMI 48 Trial.

scientific article published on 9 October 2015

Effects of tirofiban plus heparin versus heparin alone on troponin I levels in patients with acute coronary syndromes

scientific article published on 01 October 2000

Efficacy and Safety of Adding Ezetimibe to Statin Therapy Among Women and Men: Insight From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).

scientific article published on 18 November 2017

Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF-TIMI 48 Trial

scientific article published on 20 May 2016

Efficacy and Safety of Edoxaban in Patients With Active Malignancy and Atrial Fibrillation: Analysis of the ENGAGE AF - TIMI 48 Trial

Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis

scientific article published on 01 September 2018

Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants After Cardioversion for Nonvalvular Atrial Fibrillation.

scientific article

Efficacy and Safety of Novel Oral Anticoagulants in Patients With Atrial Fibrillation and Heart Failure: A Meta-Analysis

scientific article published on 28 August 2016

Efficacy and safety of edoxaban compared with warfarin in patients with atrial fibrillation and heart failure: insights from ENGAGE AF-TIMI 48.

scientific article published on 28 June 2016

Efficacy and safety of evolocumab (AMG 145), a fully human monoclonal antibody to PCSK9, in hyperlipidaemic patients on various background lipid therapies: pooled analysis of 1359 patients in four phase 2 trials

scientific article published on 04 March 2014

Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.

scientific article

Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial

scientific article

Electrocardiographic and Clinical Predictors of Acute Myocardial Infarction in Patients With Unstable Angina Pectoris ⬇️

scientific article published on May 15, 1998

Elevated serum creatinine is associated with 1-year mortality after acute myocardial infarction.

scientific article published on December 2002

Emerging antithrombotic drugs for acute coronary syndrome.

scientific article published on 13 July 2013

Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: final baseline characteristics of the IMPROVE-IT study population

scientific article published on 15 May 2014

Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial

scientific article

Evaluation of the time saved by prehospital initiation of reteplase for ST-elevation myocardial infarction: results of The Early Retavase-Thrombolysis in Myocardial Infarction (ER-TIMI) 19 trial

scientific article

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

scientific article published on 17 March 2017

ExTRACT-TIMI 25 in perspective: key lessons regarding enoxaparin as an adjunct to fibrinolytic therapy.

scientific article published on 19 October 2008

Extent of ST-segment resolution after fibrinolysis adds improved risk stratification to clinical risk score for ST-segment elevation myocardial infarction

scientific article published in January 2010

Extracranial arterial and venous thromboembolism in patients with atrial fibrillation: A meta-analysis of randomized controlled trials

scientific article published on 3 January 2017

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

scientific article

Fasting glucose, NT-proBNP, treatment with eptifibatide, and outcomes in non-ST-segment elevation acute coronary syndromes: An analysis from EARLY ACS.

scientific article published on 04 January 2017

First report of an intravenous and oral glycoprotein IIb/IIIa inhibitor (RPR 109891) in patients with recent acute coronary syndromes: results of the TIMI 15A and 15B trials.

scientific article published in July 2000

Frequency, clinical and angiographic characteristics, and outcomes of high-risk non-ST-segment elevation acute coronary syndromes patients with left circumflex culprit lesions

scientific article published on 10 November 2015

Genetics and the clinical response to warfarin and edoxaban: findings from the randomised, double-blind ENGAGE AF-TIMI 48 trial

scientific article published on 11 March 2015

Genotype-guided dosing of warfarin

scientific article published on 01 April 2014

Glycoprotein IIb-IIIa inhibitors in the emergency department for patients with non-ST-elevation acute coronary syndromes: principles and practices.

scientific article

Heart-type fatty acid binding protein as a marker of reperfusion after thrombolytic therapy

scientific article published on 01 August 2000

High-degree atrioventricular block, asystole, and electro-mechanical dissociation complicating non-ST-segment elevation myocardial infarction

scientific article

Highlights from the fifth international symposium of thrombosis and anticoagulation (ISTA V), October 18-19, 2012, Belo Horizonte, Minas Gerais, Brazil

scientific article published in July 2013

Icosapent Ethyl Reduces Ischemic Events in Patients With a History of Previous Coronary Artery Bypass Grafting: REDUCE-IT CABG

scientific article published in 2021

Identification of patients at high risk for death and cardiac ischemic events after hospital discharge

scientific article

Impact of Ezetimibe on the Rate of Cardiovascular-Related Hospitalizations and Associated Costs Among Patients With a Recent Acute Coronary Syndrome: Results From the IMPROVE-IT Trial (Improved Reduction of Outcomes: Vytorin Efficacy International T

scientific article published on May 2017

Impact of Renal Function on Outcomes With Edoxaban in the ENGAGE AF-TIMI 48 Trial

scientific article published on July 2016

Impact of time of presentation on process performance and outcomes in ST-segment-elevation myocardial infarction: a report from the American Heart Association: Mission Lifeline program

scientific article published on 29 July 2014

Importance of dose selection in novel oral anticoagulants for atrial fibrillation ⬇️

scientific article published on October 1, 2012

Improving antithrombotic treatment in patients after myocardial infarction

scientific article published in September 2003

In patients with acute myocardial infarction, the impact of hyperglycemia as a risk factor for mortality is not homogeneous across age-groups.

scientific article published on 25 October 2011

Incidence, treatment, and outcomes of atrial fibrillation complicating non-ST-segment elevation acute coronary syndromes

scientific article published on 8 April 2013

Individual Patient Data from the Pivotal Randomized Controlled Trials of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation (COMBINE AF): Design and Rationale: From the COMBINE AF (A COllaboration between Multiple inst

scientific article published on 06 December 2020

Inflammatory and Cholesterol Risk in the FOURIER Trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Patients With Elevated Risk).

scientific article published on 12 March 2018

Influence of proven oral therapies in the very old with acute coronary syndromes: A 15 year experience

scientific article published on 02 July 2015

Left atrial structure and function in atrial fibrillation: ENGAGE AF-TIMI 48.

scientific article

Left bundle branch block in non-ST-segment elevation acute coronary syndromes. Incidence, angiographic characteristics, and clinical outcomes

scientific article

Linking Endogenous Factor Xa Activity, a Biologically Relevant Pharmacodynamic Marker, to Edoxaban Plasma Concentrations and Clinical Outcomes in the ENGAGE AF-TIMI 48 Trial

scientific article published on 01 October 2018

Long-term Low-Density Lipoprotein Cholesterol-Lowering Efficacy, Persistence, and Safety of Evolocumab in Treatment of Hypercholesterolemia: Results Up to 4 Years From the Open-Label OSLER-1 Extension Study.

scientific article published on 14 March 2017

Long-term Safety and Efficacy of Achieving Very Low Levels of Low-Density Lipoprotein Cholesterol : A Prespecified Analysis of the IMPROVE-IT Trial

scientific article published on 14 March 2017

Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients With Peripheral Artery Disease: Insights From the FOURIER Trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk).

scientific article published on 13 November 2017

Low-Density Lipoprotein Cholesterol Treatment in the Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Era: Getting Back on Target

scientific article published on 01 September 2017

Low-density lipoprotein lowering in 2013 by nonstatin agents: the discovery and development of promising novel targeted therapies.

scientific article published on May 2013

Low-molecular-weight heparins for the treatment of acute coronary syndromes.

scientific article published on November 2003

Major Bleeding in Patients With Diabetes and Atrial Fibrillation Treated With New Oral Anticoagulants-Reply

scientific article published on 01 October 2017

Management of LDL-cholesterol after an acute coronary syndrome: Key comparisons of the American and European clinical guidelines to the attention of the healthcare providers

scientific article published on 29 June 2020

Management of ST-elevation myocardial infarction: an update on pharmacoinvasive recanalization.

scientific article published on January 2008

Management of ST-segment elevation myocardial infarction: Comparison of the updated guidelines from North America and Europe.

scientific article

Medication Discontinuation in the IMPROVE-IT Trial

scientific article published on 01 January 2019

Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation ⬇️

scientific article published on March 8, 2012

Modes and timing of death in 66 252 patients with non-ST-segment elevation acute coronary syndromes enrolled in 14 TIMI trials

scientific article published on 01 November 2018

Mortality in Patients with Atrial Fibrillation Randomized to Edoxaban or Warfarin: Insights from the ENGAGE AF-TIMI 48 Trial

scientific article

Neural network assessment of perioperative cardiac risk in vascular surgery patients.

scientific article published in January 1998

Neural networks, logistic regression, and calibration: a reply.

scientific article published in October 1998

New oral anticoagulants in patients with atrial fibrillation - Authors'reply

scientific article published on 01 July 2014

Niacin at 56 Years of Age — Time for an Early Retirement? ⬇️

scientific article published on November 15, 2011

Non-Vitamin K Antagonist Oral Anticoagulants for Mechanical Heart Valves

scientific article published on 01 September 2018

Non-Vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation

scientific article published on October 2016

Non-Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation and Valvular Heart Disease.

scientific article published in March 2017

Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF.

scientific article published on June 2016

North American Thrombosis Forum, AF Action Initiative Consensus Document

scientific article published on May 2016

Novel biomarkers in cardiovascular disease: update 2010.

scientific article published on October 2010

Novel oral anticoagulants in atrial fibrillation: a meta-analysis of large, randomized, controlled trials vs warfarin

scientific article published on 21 January 2013

Obesity, Diabetes, and Acute Coronary Syndrome: Differences Between Asians and Whites

scientific article published on 7 April 2017

On-treatment analysis of the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT).

scientific article published on 23 September 2016

Once- or twice-daily non-vitamin K antagonist oral anticoagulants in Asian patients with atrial fibrillation: A meta-analysis of randomized controlled trials.

scientific article

One-year outcomes after a strategy using enoxaparin vs. unfractionated heparin in patients undergoing fibrinolysis for ST-segment elevation myocardial infarction: 1-year results of the ExTRACT-TIMI 25 trial

scientific article

Oral Anticoagulation in Patients With Liver Disease.

scientific article

Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events: Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48).

scientific article published on 07 July 2016

Outcomes among non-ST-segment elevation acute coronary syndromes patients with no angiographically obstructive coronary artery disease: observations from 37,101 patients

scientific article published on 09 May 2013

Overcoming global challenges in stroke prophylaxis in atrial fibrillation: The role of non-vitamin K antagonist oral anticoagulants

scientific article

Overview of Oral Antithrombotic Treatment in Elderly Patients with Atrial Fibrillation

article

PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor's role

scientific article published on 21 April 2016

PCSK9 inhibitors for prevention of atherosclerotic cardiovascular disease

scientific article published on 01 July 2018

PCSK9 inhibitors for treating dyslipidemia in patients at different cardiovascular risk: a systematic review and a meta-analysis.

scientific article

Patterns and predictors of lipid-lowering therapy in patients with atherosclerotic cardiovascular disease and/or diabetes mellitus in 2014: Insights from a large US managed-care population

scientific article published on 27 December 2016

Performance of the thrombolysis in myocardial infarction risk index in the National Registry of Myocardial Infarction-3 and -4: a simple index that predicts mortality in ST-segment elevation myocardial infarction

scientific article published on 01 August 2004

Peri-operative Adverse Outcomes in Patients with Atrial Fibrillation Taking Warfarin or Edoxaban: Analysis of the ENGAGE AF-TIMI 48 Trial

scientific article published on 03 May 2018

Perioperative management of target-specific oral anticoagulants

scientific article published on 01 February 2014

Perspectives on the 2009 focused updates on the management of ST-segment elevation myocardial infarction and percutaneous intervention.

scientific article published on September 2010

Polyvascular disease, type 2 diabetes, and long-term vascular risk: a secondary analysis of the IMPROVE-IT trial

scientific article published on 02 November 2018

Poor outcomes after fibrinolytic therapy for ST-segment elevation myocardial infarction: impact of age (a meta-analysis of a decade of trials)

scientific article published on 01 April 2006

Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score: Results From the FOURIER Trial

scientific article published on 11 November 2019

Predictors of bleeding and time dependence of association of bleeding with mortality: insights from the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel--Thrombolysis in Myocardial Infarction 38 (T

scientific article published on 23 May 2011

Predictors of long-term mortality after hospitalization for primary unstable angina pectoris and non-ST-elevation myocardial infarction.

scientific article published in November 2003

Prevalence and clinical outcomes of undiagnosed diabetes mellitus and prediabetes among patients with high-risk non-ST-segment elevation acute coronary syndrome

scientific article

Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).

scientific article published on 30 September 2017

Prior aspirin use and outcomes in acute coronary syndromes

scientific article published on October 2010

Prognostic and Practical Validation of Current Definitions of Myocardial Infarction Associated With Percutaneous Coronary Intervention

scientific article

Prognostic implications of low level cardiac troponin elevation using high-sensitivity cardiac troponin T

scientific article published on 03 March 2015

Prognostic performance of a high-sensitivity cardiac troponin I assay in patients with non-ST-elevation acute coronary syndrome

scientific article

Prognostic value of SPECT myocardial perfusion imaging in patients with elevated cardiac troponin I levels and atypical clinical presentation.

scientific article published in January 2007

Radial versus femoral access, bleeding and ischemic events in patients with non-ST-segment elevation acute coronary syndrome managed with an invasive strategy

scientific article published on 22 February 2013

Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes

scientific article published on 2 September 2008

Rationale and design of the EMBRACE STEMI study: a phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy

scientific article published on 15 February 2013

Rationale and design of the Further cardiovascular OUtcomes Research with PCSK9 Inhibition in subjects with Elevated Risk trial.

scientific article

Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: the ANTHEM-TIMI-32 trial

scientific article (publication date: 26 June 2007)

Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome: The IMPROVE-IT Trial

scientific article published on February 2016

Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,300 patients in 4 phase II trials.

scientific article published on 5 February 2014

Reexamination of the Thrombin Hypothesis: What We Have Learned from TIMI 9B and GUSTO IIb

scientific article published on 01 January 1997

Regional patterns of use of a medical management strategy for patients with non-ST-segment elevation acute coronary syndromes: insights from the EARLY ACS Trial

scientific article published on 28 February 2012

Relation between time of symptom onset of ST-segment elevation myocardial infarction and patient baseline characteristics: from the National Cardiovascular Data Registry

scientific article

Relation of Left Ventricular Mass and Infarct Size in Anterior Wall ST-Segment Elevation Acute Myocardial Infarction (from the EMBRACE STEMI Clinical Trial).

scientific article published on 15 June 2016

Relation of impaired Thrombolysis In Myocardial Infarction myocardial perfusion grades to residual thrombus following the restoration of epicardial patency in ST-elevation myocardial infarction

scientific article

Relations between bleeding and outcomes in patients with ST-elevation myocardial infarction in the ExTRACT-TIMI 25 trial

scientific article published on 22 April 2010

Relationships Among Race, Bleeding, and Mortality in Coronary Reperfusion ⬇️

scientific article published on March 14, 2012

Reply: Adding Ezetimibe to Simvastatin for the Secondary Prevention of Cardiovascular Disease: Is it Useful?

scientific article published on 01 June 2016

Reply: Ezetimibe, Risk Stratification, and Secondary Prevention

scientific article published on 01 August 2017

Reply: Personalize and Optimize Lipid-Lowering Therapies

scientific article published on 01 July 2016

Response by Bohula et al to Letters Regarding Article, "Prevention of Stroke With the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Tria

scientific article published on 01 June 2018

Response to Letter Regarding Article, "Achievement of Dual Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein Targets More Frequent With the Addition of Ezetimibe to Simvastatin and Associated With Better Outcomes in IMPROVE

scientific article published on 01 March 2016

Response to letter regarding article, “sustained ventricular tachycardia and ventricular fibrillation complicating non–ST-segment elevation acute coronary syndromes”

scientific article published on 01 May 2013

Risk of thrombocytopenia with glycoprotein IIb/IIIa inhibitors across drugs and patient populations: a meta-analysis of 29 large placebo-controlled randomized trials

scientific article

Routine early eptifibatide versus delayed provisional use at percutaneous coronary intervention in high-risk non-ST-segment elevation acute coronary syndromes patients: an analysis from the Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment El

scientific article published on 25 July 2013

ST-segment resolution and infarct-related artery patency and flow after thrombolytic therapy. Thrombolysis in Myocardial Infarction (TIMI) 14 investigators

scientific article published on 01 February 2000

Safety and efficacy of adjusted-dose eptifibatide in patients with acute coronary syndromes and reduced renal function

scientific article

Safety and efficacy of prasugrel compared with clopidogrel in different regions of the world

scientific article published on 19 November 2010

Selecting an oral anticoagulant for patients with nonvalvular atrial fibrillation

scientific article

Selecting the best reperfusion strategy in ST-elevation myocardial infarction: it's all a matter of time

scientific article published on 01 December 2003

Sequential risk stratification using TIMI risk score and TIMI flow grade among patients treated with fibrinolytic therapy for ST-segment elevation acute myocardial infarction

scientific article published on 01 November 2004

Severity of heart failure, treatments, and outcomes after fibrinolysis in patients with ST-elevation myocardial infarction

scientific article published in October 2004

Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non-ST-Segment Elevation Acute Coronary Syndrome Patients: Insights From Clinical Trials Over 17 Years

scientific article published on 7 July 2015

Standard dose versus low dose non-vitamin K antagonist oral anticoagulants in Asian patients with atrial fibrillation: A meta-analysis of contemporary randomized controlled trials.

scientific article published on 7 September 2016

Stroke and Mortality Risk in Patients With Various Patterns of Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48).

scientific article published on January 2017

Sudden Cardiac Death in Patients With Atrial Fibrillation: Insights From the ENGAGE AF-TIMI 48 Trial

scientific article published on 08 July 2016

Sustained ventricular tachycardia and ventricular fibrillation complicating non-ST-segment-elevation acute coronary syndromes

scientific article published on 29 May 2012

Systemic, noncerebral, arterial embolism in 21,105 patients with atrial fibrillation randomized to edoxaban or warfarin: results from the Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infa

scientific article published on 02 July 2015

TIMI Risk Score for ST-Elevation Myocardial Infarction: A Convenient, Bedside, Clinical Score for Risk Assessment at Presentation : An Intravenous nPA for Treatment of Infarcting Myocardium Early II Trial Substudy

scientific article

TNK-tissue plasminogen activator compared with front-loaded alteplase in acute myocardial infarction: results of the TIMI 10B trial. Thrombolysis in Myocardial Infarction (TIMI) 10B Investigators

scientific article published on 01 December 1998

Target-specific oral anticoagulants: practice issues for the clinician.

scientific article published on August 2014

The Early Glycoprotein IIb/IIIa Inhibition in Non–ST-Segment Elevation Acute Coronary Syndrome (EARLY ACS) trial: A randomized placebo-controlled trial evaluating the clinical benefits of early front-loaded eptifibatide in the treatment of patients

article

The Effect of PCSK9 Inhibition on the Risk of Venous Thromboembolism

scientific article published on 29 March 2020

The P-glycoprotein transport system and cardiovascular drugs.

scientific article published on 03 April 2013

The Prognostic Significance of Cardiac Structure and Function in Atrial Fibrillation: The ENGAGE AF-TIMI 48 Echocardiographic Substudy

scientific article published on 20 April 2016

The Risk Score Profile: a novel approach to characterising the risk of populations enrolled in clinical studies

scientific article published on 01 July 2004

The Use of Oral Beta-Blockers and Clinical Outcomes in Patients with Non-ST-Segment Elevation Acute Coronary Syndromes: a Long-Term Follow-Up Study

scientific article published on 01 October 2018

The Year in Non–ST-Segment Elevation Acute Coronary Syndrome ⬇️

scientific article published on November 22, 2011

The benefit of adding ezetimibe to statin therapy in patients with prior coronary artery bypass graft surgery and acute coronary syndrome in the IMPROVE-IT trial

scientific article published on 28 August 2016

The facts behind niacin ⬇️

scientific article published on 05 September 2011

The independent and combined risk of diabetes and non-endstage renal impairment in non-ST-segment elevation acute coronary syndromes

scientific article published on 09 January 2008

The nonalcoholic fatty liver disease (NAFLD) fibrosis score, cardiovascular risk stratification and a strategy for secondary prevention with ezetimibe

scientific article published on 26 May 2018

The prognostic value of serum creatinine on admission in fibrinolytic-eligible patients with acute myocardial infarction.

scientific article published in December 2003

The relationship between meteorological conditions and index acute coronary events in a global clinical trial

scientific article published on 14 February 2013

The role of clopidogrel in early and sustained arterial patency after fibrinolysis for ST-segment elevation myocardial infarction: the ECG CLARITY-TIMI 28 Study

scientific article published on 12 June 2006

The role of rivaroxaban in atrial fibrillation and acute coronary syndromes

scientific article published on 21 March 2014

The year in non-ST-segment elevation acute coronary syndrome

scientific article published on 17 September 2007

The year in non-ST-segment elevation acute coronary syndrome

scientific article published on September 2008

The year in non-ST-segment elevation acute coronary syndrome

scientific article published on December 2010

The year in non-ST-segment elevation acute coronary syndromes

scientific article

The year in non-ST-segment elevation acute coronary syndromes

scientific article published on 22 June 2006

Thiazolidinedione drugs and cardiovascular risks: a science advisory from the American Heart Association and American College Of Cardiology Foundation

scientific article published in April 2010

Thiazolidinedione drugs and cardiovascular risks: a science advisory from the American Heart Association and American College of Cardiology Foundation.

scientific article published on 23 February 2010

Thrombolysis in Myocardial Infarction (TIMI) Risk Index predicts long-term mortality and heart failure in patients with ST-elevation myocardial infarction in the TIMI 2 clinical trial

scientific article published on 23 February 2009

Ticagrelor for the prevention of ischemic events in patients with prior myocardial infarction and peripheral artery disease.

scientific article published on 12 June 2018

Transition of patients from blinded study drug to open-label anticoagulation: the ENGAGE AF-TIMI 48 trial

scientific article

Treatment strategies in non-ST-elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention: an evidence-based review of clinical trial results and treatment guidelines: report on a roundtable discussion.

scientific article published on August 2008

Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment-Elevation Acute Coronary Syndromes Clinical Trials

scientific article published on 8 March 2016

Trends in clinical trials of non-ST-segment elevation acute coronary syndromes over 15 years

scientific article published on 17 February 2012

U-shaped relationship of blood glucose with adverse outcomes among patients with ST-segment elevation myocardial infarction

scientific article published in July 2005

Updates on Acute Coronary Syndrome: A Review

scientific article published on 20 July 2016

Upstream Clopidogrel Use and the Efficacy and Safety of Early Eptifibatide Treatment in Patients With Acute Coronary Syndrome

article

Upstream use of small-molecule glycoprotein iib/iiia inhibitors in patients with non-ST-segment elevation acute coronary syndromes: a systematic overview of randomized clinical trials

scientific article published on 28 June 2011

Usefulness of prodromal unstable angina pectoris in predicting better survival and smaller infarct size in acute myocardial infarction (The InTIME-II Prodromal Symptoms Substudy).

scientific article published in September 2003

Usefulness of the TIMI Risk Index in Predicting Short- and Long-Term Mortality in Patients With Acute Coronary Syndromes

article

Valvular Heart Disease Patients on Edoxaban or Warfarin in the ENGAGE AF-TIMI 48 Trial

scientific article published in March 2017

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes

scientific article

Very early risk stratification after thrombolytic therapy with a bedside myoglobin assay and the 12-lead electrocardiogram

scientific article published on 01 September 2000

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