List of works by Marcin Kortylewski

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

Abstract 2097: Characterization of mouse and cellular phenotype of ABI1 KO T-cells

scientific article published in 2022

Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism

scientific article published on 26 November 2002

Automated in vivo Assessment of Vascular Response to Radiation using a Hybrid Theranostic X-ray Irradiator/Fluorescence Molecular Imaging System

scientific article published on 15 May 2020

B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors

scientific article published on 17 January 2018

Beclin-1 as a neutrophil-specific immune checkpoint

scientific article published on 01 December 2019

Biophysical characterization of the leukemic bone marrow vasculature reveals benefits of neo-adjuvant low-dose radiotherapy

scientific article published on 22 August 2020

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.

scientific article published on 5 March 2018

Breaking bad habits: Targeting MDSCs to alleviate immunosuppression in prostate cancer

scientific article published on 24 August 2015

Breaking through a Plateau in Renal Cell Carcinoma Therapeutics: Development and Incorporation of Biomarkers ⬇️

scientific article published on November 15, 2010

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

scientific article

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

Cancer therapy using oligonucleotide-based STAT3 inhibitors: will they deliver?

scientific article

Cell-selective oligonucleotide STAT3 inhibitor for immunotherapy of human acute myeloid leukemia.

scientific article published on 4 November 2015

Combined modality radiation therapy promotes tolerogenic myeloid cell populations and STAT3-related gene expression in head and neck cancer patients.

scientific article published on 2 February 2018

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

scientific article published on January 2007

Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity

scientific article published on 01 October 2007

Cytoplasmic STAT proteins associate prior to activation.

scientific article published on February 2000

Evaluating Changes in Immune Function and Bone Microenvironment During Radium-223 Treatment of Patients with Castration-Resistant Prostate Cancer

scientific article published on 05 May 2020

Functionalized bioengineered spider silk spheres improve nuclease resistance and activity of oligonucleotide therapeutics providing a strategy for cancer treatment.

scientific article

Glioma-targeted delivery of exosome-encapsulated antisense oligonucleotides using neural stem cells

How to train your dragon: targeted delivery of microRNA to cancer cells in vivo

scientific article

Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.

scientific article

IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway

scientific article

Identification of mechanisms of resistance to treatment with abiraterone acetate or enzalutamide in patients with castration-resistant prostate cancer (CRPC).

scientific article published on 19 December 2017

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

scientific article published on 13 September 2009

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

scientific article published on 20 November 2005

Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals

scientific article published on February 2004

Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1

scientific article published on 01 June 1999

Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape

scientific article published on 15 June 2013

Knockdown (KD) of Mir-126 Expression Enhances Tyrosine Kinase Inhibitor (TKI)-Mediated Targeting of Chronic Myelogenous Leukemia (CML) Stem Cells ⬇️

scholarly article

Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity.

scientific article published on 29 October 2013

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB.

scientific article

Myeloid cell-targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell-mediated immunity

scientific article published on 24 November 2020

Myeloid cell-targeted miR-146a mimic inhibits NF-κB-driven inflammation and leukemia progression in vivo

scientific article published on 01 January 2020

Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities

scientific article published on 18 February 2017

Pazopanib as third line therapy for metastatic renal cell carcinoma: clinical efficacy and temporal analysis of cytokine profile

scientific article

Push and release: TLR9 activation plus STAT3 blockade for systemic antitumor immunity

scientific article

Reduced T-cell Numbers and Elevated Levels of Immunomodulatory Cytokines in Metastatic Prostate Cancer Patients De Novo Resistant to Abiraterone and/or Enzalutamide Therapy

scientific article published on 13 April 2019

Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment

scientific article published on February 2009

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

scientific article published on 21 December 2003

Role of Stat3 in suppressing anti-tumor immunity

scientific article published on April 2008

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

scientific article published on 23 August 2018

SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function.

scientific article

STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers

scientific article published on 18 October 2018

STAT3 Inhibition Enables TLR9-Driven Differentiation of Cbfb/Myh11 acute Myeloid Leukemia Cells to Antigen-Presenting Cell Phenotype In Vivo ⬇️

scholarly article

STAT3 in Tumor-Associated Myeloid Cells: Multitasking to Disrupt Immunity

scientific article published on 19 June 2018

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.

scientific article

STAT5 contributes to interferon resistance of melanoma cells.

scientific article published on September 2005

STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia

scientific article

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

scientific article published on 21 January 2016

Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells

scientific article published on July 2008

Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects

scientific article published on April 2005

Stat3 as a potential target for cancer immunotherapy.

scientific article published on February 2007

Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice.

scientific article published on October 2009

Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice

scientific article

Stool Bacteriomic Profiling in Patients with Metastatic Renal Cell Carcinoma Receiving Vascular Endothelial Growth Factor-Tyrosine Kinase Inhibitors

scientific article published on 7 July 2015

Synaptophysin expression on circulating tumor cells in patients with castration resistant prostate cancer undergoing treatment with abiraterone acetate or enzalutamide

scientific article published on 27 December 2017

Systemic delivery of TLR9-activating/STAT3-blocking oligonucleotides induces leukemia regression.

scientific article published on 6 November 2014

TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs

scientific article published on 22 May 2017

TLR9 is critical for glioma stem cell maintenance and targeting

scientific article

TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy

scientific article published on 23 October 2013

TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells

scientific article

TLR9 triggering/STAT3 inhibition to reprogram leukemic cells into antigen-presenting cells and trigger T-cell responses. ⬇️

scholarly article

TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients

scientific article

TLR9-Targeted SiRNA Delivery In Vivo

scientific article published on January 2016

TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo

scientific article

Targeted Delivery of miRNA Antagonists to Myeloid Cells In Vitro and In Vivo

scientific article published on 01 January 2019

Targeted Marrow Radiation (TMI) Improves Therapeutic Efficacy of STAT3 Decoy Molecules By Augmenting Its Delivery and Immune Modulation in an AML Mouse Model ⬇️

scholarly article

Targeted TLR9-activation/STAT3-blocking abrogates immunosuppressive functions of myeloid-derived suppressor cells from late-stage prostate cancer patients

Targeted in vivo delivery of NF-κB decoy inhibitor augments sensitivity of B-cell lymphoma to therapy

scientific article published on 25 November 2020

Targeting STAT3 affects melanoma on multiple fronts

scientific article

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

scientific article published on August 2005

Targeting Stat3 in the Myeloid Compartment Drastically Improves the In vivo Antitumor Functions of Adoptively Transferred T Cells ⬇️

scientific article published on September 14, 2010

Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis.

scientific article

The aptamer-siRNA conjugates: reprogramming T cells for cancer therapy

scientific article published in January 2015

The dark side of Toll-like receptor signaling: TLR9 activation limits the efficacy cancer radiotherapy

scientific article

The revival of CpG oligonucleotide-based cancer immunotherapies.

scientific article published on 5 March 2018

Time Sequential Transcriptome Analysis Identifies Mir-126 As an Early Biomarker for Inv(16) Acute Myeloid Leukemia (AML) Disease Progression ⬇️

scholarly article

Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy

scientific article published on 3 March 2009

Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML

scientific article published on 09 August 2021

Vaccination against non-mutated neoantigens induced in recurrent and future tumors

scientific article published on 15 April 2020

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