List of works - Constanze Bonifer

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program

scientific article published on 14 July 2017

A Functional chromatin domain does not resist X chromosome inactivation: silencing of cLys correlates with methylation of a dual promoter-replication origin.

scientific article

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification ⬇️

scientific article

A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene.

scientific article

An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression

scientific article published on 26 April 2010

An in vitro differentiation system for the examination of transgene activation in mouse macrophages.

scientific article published in September 1994

C/EBPbeta induces chromatin opening at a cell-type-specific enhancer.

scientific article published on 14 January 2008

C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis

scientific article

C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia

scientific article published on 01 February 2018

Characterization of RNA aptamers that disrupt the RUNX1-CBFbeta/DNA complex

scientific article published on 09 September 2009

Chromatin Structure Profiling Identifies Crucial Regulators of Tumor Maintenance

scientific article published on 05 November 2015

Chromatin domains constitute regulatory units for the control of eukaryotic genes

scientific article published on 01 January 1993

Chromatin mechanisms regulating gene expression in health and disease.

scientific article published on January 2011

Chromatin priming of genes in development: Concepts, mechanisms and consequences

scientific article published on 6 February 2017

Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation.

scientific article

Chromatin regulation by RUNX1.

scientific article published on 02 March 2010

Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature. ⬇️

scientific article published on 23 July 2015

Chronic growth factor receptor signaling and lineage inappropriate gene expression in AML: the polycomb connection.

scientific article published on July 2013

Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate

scientific article published on 17 October 2016

Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131].

scientific article published on 31 October 2017

Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice.

scientific article published on March 1999

Cytokine and proinflammatory gene expression in classical Hodgkin lymphoma: its more than NF-κB!

scientific article published on 10 January 2015

Delineating MEIS1 cis-regulatory elements active in hematopoietic cells

scientific article published on 7 October 2013

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

scientific article

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.

scientific article published on 2 May 2010

Developmental activation of the lysozyme gene in chicken macrophage cells is linked to core histone acetylation at its enhancer elements.

scientific article published on 16 August 2006

Developmental regulation of eukaryotic gene loci: which cis-regulatory information is required?

scientific article

Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.

scientific article published on 28 May 2015

Developmentally regulated recruitment of transcription factors and chromatin modification activities to chicken lysozyme cis-regulatory elements in vivo

scientific article

Different macrophage populations develop from embryonic/fetal and adult hematopoietic tissues.

scientific article published in May 1997

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

scientific article published on 04 January 2021

Differential activity of the -2.7 kb chicken lysozyme enhancer in macrophages of different ontogenic origins is regulated by C/EBP and PU.1 transcription factors.

scientific article published on August 1999

Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5.

scientific article published on 23 April 2011

Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci.

scientific article

Differentiation-dependent alterations in histone methylation and chromatin architecture at the inducible chicken lysozyme gene.

scientific article

Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice.

scientific article published on October 1994

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation. ⬇️

scientific article published on 18 February 2016

Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci ⬇️

scientific article published on October 1, 1991

Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro.

scientific article

Epigenetic mechanisms regulating normal and malignant haematopoiesis: new therapeutic targets for clinical medicine.

scientific article published on 15 February 2010

Epigenetic plasticity of hematopoietic cells.

scientific article published on 3 February 2005

Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible.

scientific article published on 14 October 2004

Evolution of gene regulation as revealed by differential regulation of the chicken lysozyme transgene and the endogenous mouse lysozyme gene in mouse macrophages

scientific article published on 01 November 1994

Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma

scientific article published on 13 December 2018

Herpesvirus saimiri-based gene delivery vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro.

scientific article published in March 2000

Identification and characterization of the protein encoded by the human c-myb proto-oncogene.

scientific article

Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal ⬇️

scientific article published on 18 September 2014

Identification of cis-acting elements as DNase I hypersensitive sites in lysozyme gene chromatin

article

Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element.

scientific article

In vivo genomic footprinting using LM-PCR methods.

scientific article published in January 2006

Inducible chromatin priming is associated with the establishment of immunological memory in T cells.

scientific article

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia.

scientific article published in November 2016

Integrated analyses of chromatin accessibility and gene expression data for elucidating the transcriptional regulatory mechanisms during early hematopoietic development in mouse.

scientific article published on 18 March 2013

Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse

scientific journal article

Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression.

scientific article published on 24 April 2013

Long-distance chromatin mechanisms controlling tissue-specific gene locus activation.

scientific article

Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis.

scientific article published on 2 October 2003

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

scientific article published on 5 July 2011

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma

scientific article

NFATc1 releases BCL6-dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice.

scientific article

PAP-LMPCR: An Improved, Sequence-Selective Method for the In Vivo Analysis of Transcription Factor Occupancy and Chromatin Fine Structure

scientific article published on 29 September 2010

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

scientific article published on August 2008

Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc Min/+ mouse model of intestinal tumorigenesis ⬇️

scientific article

Pharmacological inhibition of aberrant transcription factor complexes in inversion 16 acute myeloid leukemia

scientific article published on 30 September 2018

Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones

scientific article published on 20 September 2018

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence.

scientific article

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

scientific article

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

scientific article

RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.

scientific article

RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1.

scientific article published on 13 April 2015

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

scientific article published on 22 January 2021

Rapid, solid-phase based automated analysis of chromatin structure and transcription factor occupancy in living eukaryotic cells

scientific article

Rat antibodies as probes for the characterization of progesterone receptor A and B proteins from laying hen oviduct cytosol

scientific article published on 01 January 1988

Reduced c-myb expression levels affect hematopoietic development in vitro.

scientific article published in May 2007

Regulation of the chicken lysozyme locus in transgenic mice.

scientific article published on January 1996

Repeat-element driven activation of proto-oncogenes in human malignancies ⬇️

scientific article published on November 19, 2010

Role of positive and negative cis-regulatory elements in the transcriptional activation of the lysozyme locus in developing macrophages of transgenic mice.

scientific article published in February 1997

Runx proteins regulate Foxp3 expression

scientific article published on 19 October 2009

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

scientific article

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

scientific article

Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis

scientific article published on 2 April 2009

Subtype-specific regulatory network rewiring in acute myeloid leukemia.

scientific article

System-wide studies of the transcriptional programming of chromatin during early hematopoietic development

scientific article published on 18 March 2013

The Co-operation of RUNX1 with LDB1, CDK9 and BRD4 Drives Transcription Factor Complex Relocation During Haematopoietic Specification.

scientific article published on 10 July 2018

The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription.

scientific article

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

scientific article published on 01 October 2018

The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.

scientific article published on 4 September 2007

The RUNX1-PU.1 axis in the control of hematopoiesis.

scientific article

The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease

scientific article

The architecture of chicken chromosome territories changes during differentiation ⬇️

scientific article

The chicken lysozyme locus as a paradigm for the complex developmental regulation of eukaryotic gene loci.

scientific article published on October 1997

The developmental activation of the chicken lysozyme locus in transgenic mice requires the interaction of a subset of enhancer elements with the promoter ⬇️

scientific article published on August 1, 1997

The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus

scientific article

The hematopoietic master regulator RUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis

The leukemia-associated RUNX1/ETO oncoprotein confers a mutator phenotype

scientific article published on 8 June 2015

The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction

scientific article

The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken ⬇️

scientific article

The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis

scientific article published on January 2008

Transcription factor PU.1 controls transcription start site positioning and alternative TLR4 promoter usage.

scientific article

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells

scientific article published on July 2002

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

scientific article

UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.

scientific article published on 9 October 2015

Wellington-bootstrap: differential DNase-seq footprinting identifies cell-type determining transcription factors

scientific article published on 25 November 2015

Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data

scientific article

Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data

Why detailed model gene studies in higher eukaryotes are still necessary.

scientific article published on June 2013

cis-Regulatory remodeling of the SCL locus during vertebrate evolution.

scientific article published on 18 October 2010

List of works by Constanze Bonifer

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program

A Functional chromatin domain does not resist X chromosome inactivation: silencing of cLys correlates with methylation of a dual promoter-replication origin.

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification ⬇️

A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene.

An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression

An in vitro differentiation system for the examination of transgene activation in mouse macrophages.

C/EBPbeta induces chromatin opening at a cell-type-specific enhancer.

C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis

C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia

Characterization of RNA aptamers that disrupt the RUNX1-CBFbeta/DNA complex

Chromatin Structure Profiling Identifies Crucial Regulators of Tumor Maintenance

Chromatin domains constitute regulatory units for the control of eukaryotic genes

Chromatin mechanisms regulating gene expression in health and disease.

Chromatin priming of genes in development: Concepts, mechanisms and consequences

Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation.

Chromatin regulation by RUNX1.

Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature. ⬇️

Chronic growth factor receptor signaling and lineage inappropriate gene expression in AML: the polycomb connection.

Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate

Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131].

Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice.

Cytokine and proinflammatory gene expression in classical Hodgkin lymphoma: its more than NF-κB!

Delineating MEIS1 cis-regulatory elements active in hematopoietic cells

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.

Developmental activation of the lysozyme gene in chicken macrophage cells is linked to core histone acetylation at its enhancer elements.

Developmental regulation of eukaryotic gene loci: which cis-regulatory information is required?

Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.

Developmentally regulated recruitment of transcription factors and chromatin modification activities to chicken lysozyme cis-regulatory elements in vivo

Different macrophage populations develop from embryonic/fetal and adult hematopoietic tissues.

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

Differential activity of the -2.7 kb chicken lysozyme enhancer in macrophages of different ontogenic origins is regulated by C/EBP and PU.1 transcription factors.

Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5.

Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci.

Differentiation-dependent alterations in histone methylation and chromatin architecture at the inducible chicken lysozyme gene.

Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice.

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation. ⬇️

Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci ⬇️

Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro.

Epigenetic mechanisms regulating normal and malignant haematopoiesis: new therapeutic targets for clinical medicine.

Epigenetic plasticity of hematopoietic cells.

Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible.

Evolution of gene regulation as revealed by differential regulation of the chicken lysozyme transgene and the endogenous mouse lysozyme gene in mouse macrophages

Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma

Herpesvirus saimiri-based gene delivery vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro.

Identification and characterization of the protein encoded by the human c-myb proto-oncogene.

Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal ⬇️

Identification of cis-acting elements as DNase I hypersensitive sites in lysozyme gene chromatin

Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element.

In vivo genomic footprinting using LM-PCR methods.

Inducible chromatin priming is associated with the establishment of immunological memory in T cells.

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia.

Integrated analyses of chromatin accessibility and gene expression data for elucidating the transcriptional regulatory mechanisms during early hematopoietic development in mouse.

Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse

Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression.

Long-distance chromatin mechanisms controlling tissue-specific gene locus activation.

Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis.

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma

NFATc1 releases BCL6-dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice.

PAP-LMPCR: An Improved, Sequence-Selective Method for the In Vivo Analysis of Transcription Factor Occupancy and Chromatin Fine Structure

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc Min/+ mouse model of intestinal tumorigenesis ⬇️

Pharmacological inhibition of aberrant transcription factor complexes in inversion 16 acute myeloid leukemia

Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence.

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.

RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1.

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

Rapid, solid-phase based automated analysis of chromatin structure and transcription factor occupancy in living eukaryotic cells

Rat antibodies as probes for the characterization of progesterone receptor A and B proteins from laying hen oviduct cytosol

Reduced c-myb expression levels affect hematopoietic development in vitro.

Regulation of the chicken lysozyme locus in transgenic mice.

Repeat-element driven activation of proto-oncogenes in human malignancies ⬇️

Role of positive and negative cis-regulatory elements in the transcriptional activation of the lysozyme locus in developing macrophages of transgenic mice.

Runx proteins regulate Foxp3 expression

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers