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List of works by Raymond J Steptoe

A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin

scientific article published on 9 November 2012

APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.

scientific article published on 14 June 2017

Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation

scientific article

Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice

scientific article published on 30 June 2017

Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection

scientific article published on 9 March 2016

Antigen-specific suppression of inflammatory arthritis using liposomes.

scientific article published in March 2009

Asymmetric peptide dendrimers are effective linkers for antibody-mediated delivery of diverse payloads to b cells in vitro and in vivo

scientific article

Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid progenitor cells that differentiate in vivo into resting dendritic cells

scientific article published on 01 February 2005

Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment

scientific article

CD4+/CD8+ double-positive T cells: more than just a developmental stage?

scientific article

CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin

scientific article published on 21 June 2017

CRISPR-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success?

scientific article published on 09 March 2017

Cell-based therapies for ocular inflammation.

scientific article published on 29 March 2013

Choroidal mast cell dynamics during experimental autoimmune uveoretinitis in rat strains of differing susceptibility

article

Clinically-Relevant Rapamycin Treatment Regimens Enhance CD8+ Effector Memory T Cell Function In The Skin and Allow their Infiltration into Cutaneous Squamous Cell Carcinoma

scientific article published on 30 July 2018

Comparative analysis of dendritic cell density and total number in commonly transplanted organs: morphometric estimation in normal mice

scientific article published on 01 March 2000

Dendritic cells and tolerance induction.

scientific article published on September 1996

Dendritic cells in the thymus contribute to T-regulatory cell induction

scholarly article

Distribution and characterisation of rat choroidal mast cells.

scientific article published on March 1994

Donor bone marrow potentiates the effect of tacrolimus on nonvascularized heart allograft survival: association with microchimerism and growth of donor dendritic cell progenitors from recipient bone marrow

scientific article published on 01 February 1998

Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD.

scientific article published on 24 January 2018

Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development

article

HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions.

scientific article published on 20 January 2015

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

scientific article published on 13 March 2012

Immunobiology of liver dendritic cells.

scientific article

Immunogenic, but not steady-state, antigen presentation permits regulatory T-cells to control CD8+ T-cell effector differentiation by IL-2 modulation.

scientific article published on 13 January 2014

Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation

scientific article published on 7 September 2011

Impact of Flt-3 ligand on donor-derived antigen presenting cells and alloimmune reactivity in heart graft recipients given adjuvant donor bone marrow

scientific article published on 01 December 1998

Impaired T-Cell Function in B-Cell Lymphoma: A Direct Consequence of Events at the Immunological Synapse?

scientific article

In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours.

scientific article published on 12 November 2013

Induction of antigen-specific tolerance through hematopoietic stem cell-mediated gene therapy: the future for therapy of autoimmune disease?

scientific article published on 06 October 2012

Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy ⬇️

scientific article

Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA

scientific article published on 24 February 2011

MHC Class II Expression Is Regulated in Dendritic Cells Independently of Invariant Chain Degradation

scientific article published on 01 June 2001

Maintenance of peripheral tolerance to islet antigens.

scientific article published on 30 May 2016

Most lymphoid organ dendritic cell types are phenotypically and functionally immature

scientific article published on 5 June 2003

Origin and steady-state turnover of major histocompatibility complex Class II-positive dendritic cells and resident-tissue macrophages in the iris of the rat eye

scientific article published on 01 August 1996

Peripheral Tolerance Checkpoints Imposed by Ubiquitous Antigen Expression Limit Antigen-Specific B Cell Responses under Strongly Immunogenic Conditions

scientific article published on 24 July 2020

Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation.

scientific article published in March 2004

Proinsulin is encoded by an RNA splice variant in human blood myeloid cells.

scholarly article

Re-educating immunity in respiratory allergies: the potential for hematopoietic stem cell-mediated gene therapy.

scientific article published on 17 November 2017

Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice.

scientific article published on 14 January 2016

Regulatory T cells prevent inducible BALT formation by dampening neutrophilic inflammation.

scientific article published on 25 March 2015

Resident tissue macrophages within the normal rat iris lack immunosuppressive activity and are effective antigen-presenting cells

scientific article published on 01 September 2000

Short-course rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term immunological tolerance.

scientific article published on 9 March 2017

Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies

scientific article published on 08 December 2018

Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses

scientific article published in July 2010

Steady-state dendritic cells continuously inactivate T cells that escape thymic negative selection

scientific article published on 07 July 2009

Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses

article

Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

scientific article published on 15 January 2006

Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function

scientific article published on 7 December 2009

Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling

scientific article published on 16 March 2018

Tetramer-based identification of naïve antigen-specific B cells within a polyclonal repertoire.

scientific article published on 23 March 2018

The T-cell Receptor Repertoire Influences the Tumor Microenvironment and Is Associated with Survival in Aggressive B-cell Lymphoma.

scientific article published on 20 September 2016

The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse

scientific article published on 4 August 2017

The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation.

scientific article

Trafficking of APC from liver allografts of Flt3L-treated donors: augmentation of potent allostimulatory cells in recipient lymphoid tissue is associated with a switch from tolerance to rejection

scientific article published on 01 March 1999

Ultrastructural pathology of experimental autoimmune uveitis in the rat.

scientific article published in January 1993

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

scientific article

γδ T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen

scientific article

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