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List of works by T. Michael Redmond

9-cis Retinal increased in retina of RPE65 knockout mice with decrease in coat pigmentation

scientific article published on 01 November 2006

A History of the Classical Visual Cycle.

scientific article

Aberrant RNA splicing is the major pathogenic effect in a knock-in mouse model of the dominantly inherited c.1430A>G human RPE65 mutation

scientific article published on 25 January 2019

Acute radiolabeling of retinoids in eye tissues of normal and rpe65-deficient mice.

scientific article published in April 2003

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

scientific article

Aromatic Lipophilic Spin Traps Effectively Inhibit RPE65 Isomerohydrolase Activity ⬇️

scientific article published on July 13, 2011

Aromatic Residues in the Substrate Cleft of RPE65 Protein Govern Retinol Isomerization and Modulate Its Progression ⬇️

scientific article published on June 28, 2012

Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase

scientific article

Cloning and localization of RPE65 mRNA in salamander cone photoreceptor cells1.

scientific article

Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences.

scientific article

Cyanogen bromide fragments of bovine interphotoreceptor retinoid-binding protein induce experimental autoimmune uveoretinitis in Lewis rats.

scientific article published on April 1988

Experimental autoimmune uveoretinitis (EAU) induced by retinal interphotoreceptor retinoid-binding protein (IRBP): differences between EAU induced by IRBP and by S-antigen

scientific article published on 01 May 1987

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration

article published in the Proceedings of the National Academy of Sciences of the United States of America

Expression of beta-carotene 15,15' monooxygenase in retina and RPE-choroid.

scientific article published on January 2003

Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells.

scientific article published on August 2014

Focus on Molecules: RPE65, the visual cycle retinol isomerase.

scientific article published on 14 August 2008

IRBP from bovine retina is poorly uveitogenic in guinea pigs and is identical to A-antigen.

scientific article published in March 1987

Identification of RPE65 in transformed kidney cells

scientific article (publication date: 11 June 1999)

Identification of a KRAB-zinc finger protein binding to the Rpe65 gene promoter.

scientific article

Immune responses to peptides derived from the retinal protein IRBP: immunopathogenic determinants are not necessarily immunodominant.

scientific article published in November 1989

Immunohistochemical analysis of experimental autoimmune uveoretinitis (EAU) induced by interphotoreceptor retinoid-binding protein (IRBP) in the rat

scientific article published on 01 March 1987

Immunological features of synthetic peptides derived from the retinal protein IRBP: differences between immunodominant and non-dominant peptides

scientific article published on 01 January 1990

In vivo assessment of rodent retinal structure using spectral domain optical coherence tomography

scientific article published on 01 January 2012

In vivo gene therapy in young and adult RPE65-/- dogs produces long-term visual improvement.

scientific article published on January 2003

Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway

scientific article

Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism

scientific article published on 30 December 2015

Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desatura

scientific article

Localization of corneal superoxide dismutase by biochemical and histocytochemical techniques

scientific article published on 01 April 1984

Localization of the gene for interphotoreceptor retinoid-binding protein to mouse chromosome 14 near Np-1

scientific article published on 01 December 1990

Lymphocyte responses to retinal-specific antigens in uveitis patients and healthy subjects

scientific article published on 01 April 1988

Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye.

scientific article published in July 2005

Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage

scientific article published on 13 May 2015

Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.

scientific article

New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis.

scientific article

Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates

scientific article (publication date: 2012)

Palmitoylation of Metazoan Carotenoid Oxygenases

scientific article published on 22 April 2020

Phylogenetic analysis of the metazoan carotenoid oxygenase superfamily: a new ancestral gene assemblage of BCO-like (BCOL) proteins.

scientific article published on 16 October 2017

Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration

article by Christian Grimm et al published May 2000 in Nature Genetics

RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.

scientific article published on 30 November 2005

RPE65 takes on another role in the vertebrate retina

scientific article published on 2 October 2017

RPE65, the Major Retinal Pigment Epithelium Microsomal Membrane Protein, Associates with Phospholipid Liposomes ⬇️

scientific article (publication date: October 1997)

RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization

scientific article

Rat T-cell lines specific to a nonimmunodominant determinant of a retinal protein (IRBP) produce uveoretinitis and pinealitis.

scientific article published in August 1989

Recombinant adeno-associated virus type 2-mediated gene delivery into the Rpe65-/- knockout mouse eye results in limited rescue

scientific article

Repeated determinants within the retinal interphotoreceptor retinoid-binding protein (IRBP): Immunological properties of the repeats of an immunodominant determinant ⬇️

scientific article published on April 1, 1990

Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells.

scientific article published on 15 April 2015

Retinyl esters are the substrate for isomerohydrolase.

scientific article published in February 2003

Role of the 3'-untranslated region of RPE65 mRNA in the translational regulation of the RPE65 gene: identification of a specific translation inhibitory element

scientific article published on 01 September 1998

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.

scientific article published in December 1998

Spectral domain optical coherence tomography in mouse models of retinal degeneration.

scientific article published on 6 August 2009

Subretinal delivery and electroporation in pigmented and nonpigmented adult mouse eyes.

scientific article published on January 2012

Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration

scientific article published on 18 February 2014

Synthesis of an immunopathogenic fusion protein derived from a bovine interphotoreceptor retinoid-binding protein cDNA clone.

scientific article

Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration

scientific article published on 13 September 2016

The Rpe65 rd12 allele exerts a semidominant negative effect on vision in mice

scientific article published on 17 April 2014

The dual roles of RPE65 S-palmitoylation in membrane association and visual cycle function

scientific article published on 26 March 2019

The mechanism of fenretinide (4-HPR) inhibition of β-carotene monooxygenase 1. New suspect for the visual side effects of fenretinide

scientific article published on 01 January 2012

Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis

scientific article published on 01 January 2000

Uveitis and immune responses in primates immunized with IRBP-derived synthetic peptides

scientific article published on 01 February 1990

Uveitis induced in primates by IRBP: humoral and cellular immune responses

scientific article published on 01 November 1987

Volatile Evolution of Long Non-Coding RNA Repertoire in Retinal Pigment Epithelium: Insights from Comparison of Bovine and Human RNA Expression Profiles

article

cDNA clones encoding bovine interphotoreceptor retinoid binding protein

scientific article

mRNA for interphotoreceptor retinoid-binding protein (IRBP): Distribution and size diversity in vertebrate species

scientific article published on 01 August 1989

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