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List of works by Gordon L. Fain

A kinetic analysis of mouse rod and cone photoreceptor responses

scientific article published on 17 June 2020

AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase

scientific article

ATP consumption by mammalian rod photoreceptors in darkness and in light.

scientific article published on 11 December 2008

Adaptation in vertebrate photoreceptors.

scientific article

Adaptation of mammalian photoreceptors to background light: putative role for direct modulation of phosphodiesterase.

scientific article published on 16 September 2011

Background light produces a recoverin-dependent modulation of activated-rhodopsin lifetime in mouse rods.

scientific article

Bleached pigment activates transduction in isolated rods of the salamander retina

scientific article published on 01 October 1994

Bleached pigment produces a maintained decrease in outer segment Ca2+ in salamander rods

scientific article published in January 1998

Bleaching of mouse rods: microspectrophotometry and suction-electrode recording

scientific article published on 25 March 2012

Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate

scientific article

Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors.

scientific article

Calcium and the mechanism of light adaptation in vertebrate photoreceptors

scientific article published on September 1990

Calcium in dark-adapted toad rods: evidence for pooling and cyclic-guanosine-3'-5'-monophosphate-dependent release.

scientific article published in August 1987

Calcium spikes in toad rods

scientific article published on 01 June 1980

Calcium-dependent regenerative responses in rods

scientific article published on 01 October 1977

Cambrian origin of the CYP27C1-mediated vitamin A1-to-A2 switch, a key mechanism of vertebrate sensory plasticity.

scientific article published on 5 July 2017

Channel modulation and the mechanism of light adaptation in mouse rods

scientific article

Cones and Cone Pathways Remain Functional in Advanced Retinal Degeneration

preprint of a scholarly article

Cones and cone pathways remain functional in advanced retinal degeneration

scientific article published on 24 April 2023

Constitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark.

scientific article published on August 2007

Constitutive opsin signaling: night blindness or retinal degeneration?

scientific article

Contribution of a caesium-sensitive conductance increase to the rod photoresponse ⬇️

scientific article published on March 30, 1978

Cytoplasmic calcium as the messenger for light adaptation in salamander rods

scientific article published on 01 September 1989

D-aspartate potentiates the effects of L-glutamate on horizontal cells in goldfish retina ⬇️

scientific article published on September 1, 1981

Dark adaptation in vertebrate photoreceptors.

scientific article published on November 1996

Dark adaptation.

scientific article

Detection of single photons by toad and mouse rods.

scientific article

Diminished Cone Sensitivity in cpfl3 Mice Is Caused by Defective Transducin Signaling

scientific article published on 01 April 2020

Early receptor current of wild-type and transducin knockout mice: photosensitivity and light-induced Ca2+ release

scientific journal article

Effect of knocking down the insulin receptor on mouse rod responses

scientific article published on 19 January 2015

Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling.

scientific article

Effects of low AIPL1 expression on phototransduction in rods

scientific article published on 01 May 2006

Electrophysiological methods for measurement of activation of phototransduction by bleached visual pigment in salamander photoreceptors

scientific article published on 01 January 2000

Elevated energy requirement of cone photoreceptors

scientific article published on 27 July 2020

Functional and morphological differentiation of nonpigmented ciliary body epithelial cells grown on collagen rafts.

scientific article

Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q).

scientific article published on 24 July 2008

GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase.

scientific article

How rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception

scientific article

Interactions of rod and cone signals in the mudpuppy retina ⬇️

scientific article published on November 1, 1975

Intracellular Recordings from Single Rods and Cones in the Mudpuppy Retina ⬇️

scientific article published on June 15, 1973

Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity.

scientific article published on April 2009

Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity.

scientific article published on 20 May 2009

Lamprey vision: Photoreceptors and organization of the retina

scientific article published on 09 November 2019

Light adaptation and the evolution of vertebrate photoreceptors.

scientific article

Light adaptation in cone photoreceptors of the salamander: a role for cytoplasmic calcium

scientific article published on 01 January 1990

Light adaptation in toad rods: requirement for an internal messenger which is not calcium ⬇️

scientific article published on December 1, 1979

Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof.

scientific article published in January 2003

Light, Ca2+, and photoreceptor death: new evidence for the equivalent-light hypothesis from arrestin knockout mice.

scientific article

Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells

scientific article published on 02 May 2019

Light-dependent changes in outer segment free-Ca2+ concentration in salamander cone photoreceptors.

scientific article

Light-dependent ion influx into toad photoreceptors ⬇️

scientific article published on October 1, 1982

Light-induced Ca2+ release in the visible cones of the zebrafish.

scientific article published in July 2004

Light-induced calcium release and re-uptake in toad rods.

scientific article

Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment

scientific article

Measurement of cytoplasmic calcium concentration in the rods of wild-type and transducin knock-out mice

scientific article

Mechanisms of synaptic transmission in the retina.

scientific article published on January 1983

Membrane conductances of mouse cone photoreceptors

scientific article published on 01 March 2020

Membrane conductances of photoreceptors

scientific article published on 01 January 1981

Modulation of mouse rod photoreceptor responses by Grb14 protein

scientific article

Modulation of mouse rod response decay by rhodopsin kinase and recoverin

scientific article

Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptors.

scientific article published on February 2008

Neurotransmitter receptors of starburst amacrine cells in rabbit retinal slices.

scientific article

Night blindness and the mechanism of constitutive signaling of mutant G90D rhodopsin

scientific article published on November 2008

Nonpigmented cells of the rabbit ciliary body epithelium. Tissue culture and voltage-gated currents ⬇️

scientific article published on April 1, 1991

Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice

scientific article

Persistent activation of transducin by bleached rhodopsin in salamander rods.

scientific article

Photoreceptor degeneration in vitamin A deprivation and retinitis pigmentosa: the equivalent light hypothesis.

scientific article published in September 1993

Photoreceptor light adaptation is mediated by cytoplasmic calcium concentration

scientific article published in Nature

Phototransduction and the evolution of photoreceptors.

scientific article published on February 2010

Phototransduction: Making the Chromophore to See Through the Murk

scientific article

Physiological studies of the interaction between opsin and chromophore in rod and cone visual pigments.

scientific article published on January 2010

Quantum Sensitivity of Rods in the Toad Retina ⬇️

scientific article published on 01 March 1975

Receptor coupling in the toad retina

scientific article published on 01 January 1976

Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response

scientific article published on 30 November 2006

Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation.

scientific article

Rod Photoreceptors Avoid Saturation in Bright Light by the Movement of the G Protein Transducin

scientific article published on 16 February 2021

Rod and cone interactions in the retina.

scientific article published on 23 May 2018

Role of cytoplasmic calcium concentration in the bleaching adaptation of salamander cone photoreceptors

scientific article published on 01 January 1996

Role of recoverin in rod photoreceptor light adaptation

scientific article published on 12 February 2018

Sensitivity of toad rods: Dependence on wave-length and background illumination.

scientific article published in September 1976

Separate ON and OFF pathways in vertebrate vision first arose during the Cambrian

scientific article published on 01 June 2020

Setting the absolute threshold of vision

scientific article

Simultaneous measurement of current and calcium in the ultraviolet-sensitive cones of zebrafish

scientific article published on 23 November 2006

Single-photon sensitivity of lamprey rods with cone-like outer segments.

scientific article

Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis

scientific article published on 21 September 2003

Starburst amacrine cells change from spiking to nonspiking neurons during retinal development

scientific article published on July 1996

Support for the equivalent light hypothesis for RP.

scientific article published on December 1995

Synergistic Rise in Ca2+Produced by Somatostatin and Acetylcholine in Ciliary Body Epithelial Cells ⬇️

scientific article published on April 1, 1997

Synergistic receptor-activated calcium increases in single nonpigmented epithelial cells ⬇️

scientific article published on July 1, 1998

The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx

scientific article published in Journal of Biological Chemistry

The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice.

scientific article

The effect of light on outer segment calcium in salamander rods

scientific article published on 29 August 2003

The effects of low calcium and background light on the sensitivity of toad rods

scientific article published on 01 September 1982

The effects of sodium replacement on the responses of toad rods

scientific article published on 01 September 1982

The effects of tetraethylammonium and cobalt ions on responses to extrinsic current in toad rods

scientific article published on 01 June 1980

The evolution of rod photoreceptors.

scientific article published on April 2017

The excitatory and inhibitory amino acid receptors on horizontal cells isolated from the white perch retina

scientific article published on 01 July 1993

Time course and magnitude of the calcium release induced by bright light in salamander rods.

scientific article

Voltage signal of photoreceptors at visual threshold ⬇️

scientific article published on January 13, 1977

Voltage-activated currents recorded from rabbit pigmented ciliary body epithelial cells in culture

scientific article published on 01 November 1989

Voltage-clamp recordings of light responses from wild-type and mutant mouse cone photoreceptors

scientific article published on 27 September 2019

Whole-cell currents activated at nicotinic acetylcholine receptors on ganglion cells isolated from goldfish retina

scientific article published on 01 March 1993

Why are rods more sensitive than cones?

scientific article

Why photoreceptors die (and why they don't).

scientific article

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