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List of works by Marten P Smidt

<i>ZNF91</i> deletion in human embryonic stem cells leads to ectopic activation of SVA retrotransposons and up-regulation of KRAB zinc finger gene clusters

scientific article published on 15 March 2021

A homeodomain gene Ptx 3 has highly restricted brain expression in mesencephalic dopaminergic neurons ⬇️

scientific article published on November 25, 1997

A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b.

scientific article published on April 2000

Acquisition of the Midbrain Dopaminergic Neuronal Identity ⬇️

scientific article published on 30 June 2020

Alterations in serotonin signalling are involved in the hyperactivity of Pitx3-deficient mice.

scientific article published in January 2008

Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe

scientific article published on 11 October 2019

Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons.

scientific article published on 3 April 2014

Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice

scientific article

Embryonic development of selectively vulnerable neurons in Parkinson's disease.

scientific article

Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function

scientific article published on 15 February 2016

Epigenetic mechanisms in the development and maintenance of dopaminergic neurons

scientific article

Expression analyzes of early factors in midbrain differentiation programs.

scientific article

FoxK2 is required for cellular proliferation and survival.

scientific article published on May 2015

FoxO6 affects Plxna4-mediated neuronal migration during mouse cortical development.

scientific article published on 24 October 2016

FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling

scientific article

Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development

scientific article published on 17 May 2012

Homeobox gene Prx 3 expression in rodent brain and extraneural tissues ⬇️

scientific article published on November 25, 1997

Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons

scientific article

Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription.

scientific article published on 22 May 2014

Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons ⬇️

scientific article published on October 1, 2003

LMX1B is part of a transcriptional complex with PSPC1 and PSF.

scientific article

Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2

scientific journal article

Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.

scientific article

Mesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling

scientific article

Mest/Peg1 Is Essential for the Development and Maintenance of a SNc Neuronal Subset

scientific article published on January 2016

Mice hypomorphic for Pitx3 show robust entrainment of circadian behavioral and metabolic rhythms to scheduled feeding

scientific article published in 2022

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

scientific article published on 22 December 2009

Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities

scientific article (publication date: 2008)

Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets.

scientific article published on 19 July 2017

Molecular marker differences relate to developmental position and subsets of mesodiencephalic dopaminergic neurons

scientific article

Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives.

scientific article

Molecular mechanisms underlying midbrain dopamine neuron development and function ⬇️

scientific article published on November 7, 2003

Molecular programming of stem cells into mesodiencephalic dopaminergic neurons

scientific article published on 9 October 2006

Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area.

scientific article

Neurohypophysial dysmorphogenesis in mice lacking the homeobox gene Uncx4.1.

scientific article published in February 2006

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons ⬇️

scientific article published on March 31, 1998

Phenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement components

scientific journal article

Phox2b influences the development of a caudal dopaminergic subset

scientific article

Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool

scientific article published on 11 August 2017

Pitx3 deficiency in mice affects cholinergic modulation of GABAergic synapses in the nucleus accumbens.

scientific article published on 12 July 2006

Prenatal fluoxetine exposure induces life-long serotonin 5-HT₃ receptor-dependent cortical abnormalities and anxiety-like behaviour.

scientific article

Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency.

scientific article published in July 2007

Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons

scientific article published in December 2011

S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration.

scientific article published on 28 January 2013

Spatial and temporal lineage analysis of a Pitx3-driven Cre-recombinase knock-in mouse model.

scientific article

Strategies to unravel molecular codes essential for the development of meso-diencephalic dopaminergic neurons.

scientific article published on 29 June 2006

Subset specification of central serotonergic neurons

scientific article

Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1

scientific article published on 21 November 2018

Tcf12 Is Involved in Early Cell-Fate Determination and Subset Specification of Midbrain Dopamine Neurons

scientific article published in November 2017

The BCL2 code to dopaminergic development and Parkinson's disease.

scientific article

The bZip transcription factor vitellogenin‐binding protein is post transcriptional down regulated in chicken liver ⬇️

scientific article published on August 15, 1998

The serotonin 5-HT3 receptor: a novel neurodevelopmental target.

scientific article published on 27 May 2013

miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation.

scientific article published on 2 March 2018

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