Search filters

List of works by Pablo Tamayo

A Curated Resource for Phosphosite-specific Signature Analysis

scientific article published on 18 December 2018

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

article

A functional landscape of resistance to ALK inhibition in lung cancer

scientific article

A genetic basis for the variation in the vulnerability of cancer to DNA damage

scientific article

A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation

scientific journal article

A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors

scientific article

A strategy for oligonucleotide microarray probe reduction

scientific article

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy

scientific article published on 24 December 2018

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

scientific article

An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity

scientific article

An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome

scientific article

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

scientific article published in Nature Communications

Automated high-dimensional flow cytometric data analysis

scientific article

Breast cancer stratification from analysis of micro-array data of micro-dissected specimens.

scientific article

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

scientific article

Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation

scientific article published on 13 January 2020

Characterizing genomic alterations in cancer by complementary functional associations

scientific article published on 18 April 2016

Chemosensitivity prediction by transcriptional profiling

scientific article

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

scientific article published on 16 May 2019

Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas.

scientific article published on 17 February 2004

Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation

scientific article

Comprehensive Genomic Profiling Reveals Diverse but Actionable Molecular Portfolios across Hematologic Malignancies: Implications for Next Generation Clinical Trials

scientific article published on 21 December 2018

Constellation Map: Downstream visualization and interpretation of gene set enrichment results

scientific article published on 24 June 2015

Cyclin E Overexpression in Human Mammary Epithelial Cells Promotes Epithelial Cancer-Specific Copy Number Alterations

scientific article published on 27 August 2019

Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells

scientific article published on 21 June 2008

DNA methylation identifies genetically and prognostically distinct subtypes of myelodysplastic syndromes

scientific article published on 01 October 2019

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

scientific article published on August 2017

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

scientific article

DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

scientific article published on 24 March 2016

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning ⬇️

scientific article published on January 1, 2002

Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks

scientific article

Distinct physiological states of Plasmodium falciparum in malaria-infected patients

scientific article

Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors.

scientific article published on 15 May 2012

Estimating dataset size requirements for classifying DNA microarray data

scientific article

Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations.

scientific article published on 17 May 2017

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

scientific article

Functional precision medicine identifies new therapeutic candidates for medulloblastoma

scientific article published on 12 October 2020

GSEA-P: a desktop application for Gene Set Enrichment Analysis

scientific article published on 20 July 2007

Gene expression correlates of clinical prostate cancer behavior

article

Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.

scientific article published in April 2003

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

scientific article

Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response

scientific article

GeneCluster 2.0: an advanced toolset for bioarray analysis

scientific article

GeneCruiser: a web service for the annotation of microarray data

scientific article published on 19 July 2005

GenePattern 2.0

scientific article (publication date: May 2006)

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

scientific article published on September 2016

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

scientific article published on 28 June 2018

Genomic and Proteomic Alterations in Desmoplastic Small Round Blue-Cell Tumors

scientific article published on 01 June 2018

HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers

scientific article published on 26 August 2020

High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates

scientific article

High-throughput Phenotyping of Lung Cancer Somatic Mutations

scientific article published on 28 July 2016

High-throughput Phenotyping of Lung Cancer Somatic Mutations

scientific article published in December 2017

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

scientific article

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

scientific article

Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network

scientific article

Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

scientific article published on 05 June 2019

Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.

scientific article

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

scientific article

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

scientific article

Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers

scientific article

Integrative functional genomics identifies RINT1 as a novel GBM oncogene ⬇️

scientific article published on October 16, 2012

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

scientific article

Integrative radiogenomic profiling of squamous cell lung cancer

scientific article published on 26 August 2013

Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation

scientific article (publication date: 16 March 1999)

Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric data

scientific article

KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine

scientific article

Kataegis Expression Signature in Breast Cancer Is Associated with Late Onset, Better Prognosis, and Higher HER2 Levels.

scientific article published on 29 June 2016

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

scientific article

MB-103DiSCoVERing INNOVATIVE THERAPIES: COMBINING GENETICALLY ACCURATE DISEASE MODELS OF MEDULLOBLASTOMA WITH ADVANCED IN SILICO ANALYSIS TO IDENTIFY NOVEL THERAPEUTIC TARGETS.

scientific article published on 30 May 2016

MB-27PATHWAY ANALYSIS OF A HUMAN NEURAL STEM CELL MODEL OF AGGRESSIVE MEDULLOBLASTOMA REVEALS CKD INBHIBITION AS A POTENTIAL THERAPEUTIC MODALITY.

scientific article published on 21 April 2015

MBRS-30. TORC1/2 INHIBITION SENSITIZES MYC-DRIVEN MEDULLOBLASTOMA CELLS TO CARBOPLATIN CHEMOTHERAPY.

scientific article published on 22 June 2018

MBRS-65. CHEMI-GENOMIC ANALYSIS OF PATIENT-DERIVED XENOGRAFTS TO IDENTIFY PERSONALIZED THERAPIES FOR MEDULLOBLASTOMA.

scientific article published on 22 June 2018

MEDULLOBLASTOMA

MYC regulation of a "poor-prognosis" metastatic cancer cell state

scientific article

Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression

scientific article published on 23 January 2020

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

scientific article (publication date: 22 July 2012)

Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers

scientific article published on 10 April 2020

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

scientific article

Metagene projection for cross-platform, cross-species characterization of global transcriptional states

scholarly article

Metagenes and molecular pattern discovery using matrix factorization

scholarly article

Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells

scientific article published on 10 July 2019

MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma

scientific article

Modelling bistable tumour population dynamics to design effective treatment strategies

scientific article published on 09 May 2019

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

scientific article (publication date: 15 October 1999)

Molecular classification of multiple tumor types

scientific article published in January 2001

Molecular signatures database (MSigDB) 3.0.

scientific article

Multiclass cancer diagnosis using tumor gene expression signatures ⬇️

scientific article (publication date: 18 December 2001)

OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma

scientific article published on 17 February 2017

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

scientific article published on 01 September 2018

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

scientific article (publication date: July 2003)

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 30 September 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 11 November 2014

Portraits of breast cancer progression

scientific article

Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features

scientific article

Prediction of central nervous system embryonal tumour outcome based on gene expression

scientific article (publication date: 24 January 2002)

Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome ⬇️

scientific article published on May 6, 2012

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

scientific article

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups

scientific article published on 01 September 2018

Publisher Correction: Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers.

scientific article published on 29 May 2019

Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation

scientific article published on 16 December 2015

Role of ultra-violet mutational signature versus tumor mutation burden in predicting response to immunotherapy

scientific article published on 12 June 2020

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas ⬇️

scientific article

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer

scientific article published on December 2013

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

scientific article published on 08 January 2020

Subclass mapping: identifying common subtypes in independent disease data sets

scientific article

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

scientific article

Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles

scientific article

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

scientific article (publication date: 5 November 2009)

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

scientific article published on 13 June 2013

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

scientific article

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

scientific article published on August 2012

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

scientific article

The GenePattern Notebook Environment

scientific article published on 14 August 2017

The Molecular Signatures Database (MSigDB) hallmark gene set collection

scientific article

The limitations of simple gene set enrichment analysis assuming gene independence ⬇️

scientific article published on October 14, 2012

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo

scientific article published on 29 October 2019

Tissue- and development-stage-specific mRNA and heterogeneous CNV signatures of human ribosomal proteins in normal and cancer samples

scientific article published on 11 June 2020

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.

scientific article

Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis

scientific article

WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer

scientific article published on 01 November 2020

Paulina is supported by:

About Paulina

Help