List of works by Thomas Harrison

A Population Genomics Approach to Assessing the Genetic Basis of Within-Host Microevolution Underlying Recurrent Cryptococcal Meningitis Infection.

scientific article published on 10 February 2017

A phase II randomized controlled trial adding oral flucytosine to high-dose fluconazole, with short-course amphotericin B, for cryptococcal meningitis

scientific article published on July 2012

A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200 mg oral fluconazole in Blantyre, Malawi

scientific article

A randomised Phase II trial to evaluate the toxicity of high-dose rifampicin to treat pulmonary tuberculosis.

scientific article published on June 2016

AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial

scientific article published on 17 June 2015

AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial

scientific article published on 23 November 2018

AMBIsome Therapy Induction OptimisatioN (AMBITION): High dose AmBisome for cryptococcal meningitis induction therapy in sub-Saharan Africa: economic evaluation protocol for a randomised controlled trial-based equivalence study

scientific article published on 01 April 2019

Access to antifungal medicines in resource-poor countries - authors' reply

scientific article published on 01 May 2014

Addition of flucytosine to fluconazole for the treatment of cryptococcal meningitis in Africa: a multi-country cost-effectiveness analysis

scientific article published on 01 January 2020

Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial

scientific article published on June 2012

Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases

scientific article

Advances in the diagnosis and treatment of fungal infections of the CNS.

scientific article published on 21 February 2018

Adverse Effects and Choice between the Injectable Agents Amikacin and Capreomycin in Multidrug-Resistant Tuberculosis

scientific article published on 10 July 2017

Airway and parenchymal manifestations of pulmonary aspergillosis.

scientific article published on 20 May 2013

Amphotericin B plus fluconazole for HIV-associated cryptococcal meningitis.

scientific article published in June 2009

Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa.

scientific article published in March 2018

Antiretroviral roll-out, antifungal roll-back: access to treatment for cryptococcal meningitis

scientific article published in September 2005

Arylacetamide deacetylase (AADAC) gene polymorphism and HIV infection affect the exposure of Rifapentine: a population pharmacokinetics analysis

article

Association of Mannose‐Binding Lectin Deficiency with Acute Invasive Aspergillosis in Immunocompromised Patients

scientific article published on 01 November 2009

Brief Report

scientific article published on 01 August 2018

Cerebrospinal fluid HIV-1 viral load during treatment of cryptococcal Meningitis.

scientific article published on April 2010

Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis

scientific article published on 8 April 2015

Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation

scientific article

Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases

scientific article

Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.

scientific article

Combination flucytosine and high-dose fluconazole compared with fluconazole monotherapy for the treatment of cryptococcal meningitis: a randomized trial in Malawi

scientific article published in February 2010

Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis

scientific article published on 3 November 2011

Correction to: AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial

scientific article published on 14 January 2019

Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa

scientific article (publication date: 2013)

Cryptococcal Antigen Screening in Asymptomatic HIV-Infected Antiretroviral Naïve Patients in Cameroon and Evaluation of the New Semi-Quantitative Biosynex CryptoPS Test.

scientific article published on 13 March 2018

Cryptococcal Antigen Screening in Patients Initiating ART in South Africa: A Prospective Cohort Study

scientific article published on 12 November 2015

Cryptococcal Meningitis Screening and Community-based Early Adherence Support in People With Advanced Human Immunodeficiency Virus Infection Starting Antiretroviral Therapy in Tanzania and Zambia: A Cost-effectiveness Analysis

scientific article published on 01 April 2020

Cryptococcal antigen screening and preemptive therapy in patients initiating antiretroviral therapy in resource-limited settings: a proposed algorithm for clinical implementation

scientific article published on 26 September 2012

Cryptococcal antigen screening for patients initiating antiretroviral therapy: time for action

scientific article published in December 2010

Cryptococcal antigen screening in HIV-infected adults: let's get straight to the point.

scientific article published on 10 November 2015

Cryptococcal immune reconstitution inflammatory syndrome

scientific article published on February 2013

Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia.

scientific article

Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial

scientific article published on 10 March 2015

Cryptococcal meningitis.

scientific article published in August 2017

Cryptococcal meningitis: A neglected NTD?

scientific article published on 29 June 2017

Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy

scientific article published on 25 November 2016

Cryptococcal-related Mortality Despite Fluconazole Preemptive Treatment in a Cryptococcal Antigen Screen-and-Treat Program

scientific article published on 01 April 2020

Cryptococcus neoformans and cryptococcosis.

scientific article

Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis

scientific article published on 14 August 2013

Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes

scientific article published on 06 December 2013

Dose response effect of high-dose fluconazole for HIV-associated cryptococcal meningitis in southwestern Uganda

scientific article published in December 2008

Drug resistant TB: UK multicentre study (DRUMS): Treatment, management and outcomes in London and West Midlands 2008-2014.

scientific article published on 17 December 2016

Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis

scientific article published on 28 January 2019

Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis

article

Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days.

scientific article published on 28 January 2014

Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis

scientific article

Evaluation of a novel point-of-care cryptococcal antigen test on serum, plasma, and urine from patients with HIV-associated cryptococcal meningitis

scientific article

Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis

scientific article published on 20 March 2017

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal

scientific article

Forgotten but not gone: HIV-associated cryptococcal meningitis

scientific article published on 9 March 2016

Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole

scientific article published on 25 May 2007

Fungal infections in HIV/AIDS.

scientific article

Genomic epidemiology of Cryptococcus yeasts identifies adaptation to environmental niches underpinning infection across an African HIV/AIDS cohort.

scientific article published on 19 October 2016

Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa

scientific article published on 25 June 2015

HIV-associated cryptococcal meningitis.

scientific article published in October 2007

Healthcare Costs and Life-years Gained From Treatments Within the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) Trial on Cryptococcal Meningitis: A Comparison of Antifungal Induction Strategies in Sub-Saharan Africa

scientific article published on 01 August 2019

High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis

article

High ongoing burden of cryptococcal disease in Africa despite antiretroviral roll out

scientific article

High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial

scientific article published in July 2008

Histopathology of the arachnoid granulations and brain in HIV-associated cryptococcal meningitis: correlation with cerebrospinal fluid pressure

scientific article published on January 2010

Hydatid disease of the heart ⬇️

scientific article published in March 2005

Immune correlates of HIV-associated cryptococcal meningitis

scientific article

Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis

scientific article published on 15 November 2006

Immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis: a prospective study

scientific article published in June 2009

Immunotherapy for fungal infections

scientific article published on 10 August 2012

Impact of Routine Cryptococcal Antigen Screening and Targeted Preemptive Fluconazole Therapy in Antiretroviral-naive Human Immunodeficiency Virus–infected Adults With CD4 Cell Counts <100/μL: A Systematic Review and Meta-analysis

scientific article published on 01 February 2019

Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients

scientific article published in September 2009

Intrathecal production and secretion of vascular endothelial growth factor during Cryptococcal Meningitis.

scientific article published on 18 August 2004

Is HIV-associated tuberculosis a risk factor for the development of cryptococcal disease?

scientific article published in February 2010

Ischemic stroke as a complication of cryptococcal meningitis and immune reconstitution inflammatory syndrome: a case report

scientific article published on 16 October 2018

Itraconazole and antiretroviral therapy: strategies for empirical dosing - Author's reply

scientific article published in November 2017

Large volume lumbar punctures in cryptococcal meningitis clear cryptococcal antigen as well as lowering pressure

scientific article published on 14 September 2011

Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries

scholarly article by Angela Loyse et al published 18 October 2018 in Lancet Infectious Diseases

Long term mortality and disability in Cryptococcal Meningitis: a systematic literature review.

scientific article published on 4 October 2017

Low diversity Cryptococcus neoformans variety grubii multilocus sequence types from Thailand are consistent with an ancestral African origin

scientific article

Lumbar drainage for control of raised cerebrospinal fluid pressure in cryptococcal meningitis: case report and review

scientific article

Managing cryptococcosis in the immunocompromised host

scientific article published on December 2008

Multidrug-resistant tuberculosis (MDR-TB) treatment in the UK: a study of injectable use and toxicity in practice

scientific article

Neurological, visual, and MRI brain scan findings in 87 South African patients with HIV-associated cryptococcal meningoencephalitis

scientific article published on 22 October 2014

One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi

scientific article published on 01 January 2020

Optimal doses of rifampicin in the standard drug regimen to shorten tuberculosis treatment duration and reduce relapse by eradicating persistent bacteria

scientific article published on 12 December 2017

Oral versus intravenous flucytosine in patients with human immunodeficiency virus-associated cryptococcal meningitis.

scientific article published on 28 December 2006

Outcomes of cryptococcal meningitis in antiretroviral naïve and experienced patients in South Africa

scientific article

Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients.

scientific article published on 18 April 2013

Poor specificity of urinary cryptococcal antigen testing: Reply to Drain et al. Prevalence of cryptococcal antigenuria at initial HIV diagnosis in KwaZulu-Natal.

scientific article published on 7 September 2015

Positive predictive value of the UK clinical case definition for H1N1/09 (‘swine’) influenza

scientific article published on 07 February 2010

Primary cytomegalovirus infectious colitis complicating Crohn's disease successfully treated with oral valganciclovir

scientific article published on 16 December 2009

Pulmonary Cryptococcosis

scientific article published in April 2008

Pulmonary cryptococcosis misdiagnosed as smear-negative pulmonary tuberculosis with fatal consequences

scientific article published on 17 June 2010

Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures

scientific article published in March 2009

Reply to Pasqualotto

scientific article published on 15 October 2008

Reply to Rajasingham and Boulware

scientific article published on 01 August 2019

Role of capsule and interleukin-6 in long-term immune control of Cryptococcus neoformans infection by specifically activated human peripheral blood mononuclear cells.

scientific article published on September 2006

Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South Africa

scientific article published in April 2009

Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus–associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial

scientific article published on 26 June 2018

Should antiretroviral therapy be delayed for 10 weeks for patients treated with fluconazole for cryptococcal meningitis?

scientific article published on October 2010

Southern African HIV Clinicians Society guideline for the prevention, diagnosis and management of cryptococcal disease among HIV-infected persons: 2019 update

scientific article published on 08 November 2019

Symptomatic relapse of HIV-associated cryptococcal meningitis after initial fluconazole monotherapy: the role of fluconazole resistance and immune reconstitution

scientific article published on 7 September 2006

Tackling the emerging threat of antifungal resistance to human health

scientific article published in September 2022

Testing but not treating: missed opportunities and lost lives in the South African antiretroviral therapy programme

scientific article

The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis

scientific article (publication date: 11 January 2017)

The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis.

scientific article published on 18 May 2018

The Nramp orthologue of Cryptococcus neoformans is a pH-dependent transporter of manganese, iron, cobalt and nickel.

scientific article published on January 2005

The burden of HIV-associated cryptococcal disease

scientific article published on 01 February 2009

The costs of providing antiretroviral therapy services to HIV-infected individuals presenting with advanced HIV disease at public health centres in Dar es Salaam, Tanzania: Findings from a randomised trial evaluating different health care strategies

scientific article published on 24 February 2017

The first 5 years of Part 2A Orders: the use of powers from court applications to protect public health in England 2010-15.

scientific article published on 24 March 2018

The importance of antimicrobial resistance in medical mycology

scientific article published on 12 September 2022

The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis

scientific article published on 14 March 2013

The treatment of a pregnant HIV positive patient with cryptococcal meningitis in Malawi. Case report and review of treatment options

article

Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis

scientific article published on 8 September 2015

Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level.

scientific article published on 5 July 2017

Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence

scientific article published on 18 December 2018

Understanding Causal Pathways in Cryptococcal Meningitis Immune Reconstitution Inflammatory Syndrome

scientific article published on 01 January 2019

Very low levels of 25-hydroxyvitamin D are not associated with immunologic changes or clinical outcome in South African patients with HIV-associated cryptococcal meningitis

scientific article

XDR-TB transmission in London: Case management and contact tracing investigation assisted by early whole genome sequencing.

scientific article published on 13 June 2016

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