List of works - Hana Raslova

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

scientific article

A new heterozygous mutation in GP1BA gene responsible for macrothrombocytopenia

scientific article

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

scientific article (publication date: 28 April 2005)

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0

scientific article

CK2: a key regulator of thrombopoiesis.

scientific article

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

scientific article published on 25 November 2015

Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26-related Thrombocytopenia and MYH9-related diseases.

scientific article published on 12 March 2018

Concomitant germ-line RUNX1 and acquired ASXL1 mutations in a T-cell acute lymphoblastic leukemia.

scientific article published on 28 June 2013

Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.

scientific article published on 27 November 2017

Developmental changes in human megakaryopoiesis.

scientific article published in September 2013

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity

scientific article published on 02 January 2019

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

scientific article published in July 2011

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression

scientific article published on 16 August 2012

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

scientific article published in March 2017

Eltrombopag, a potent stimulator of megakaryopoiesis.

scientific article published on December 2016

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

scientific article published on 17 August 2015

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors

scientific article

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients

scientific article

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

scientific article

Immunophenotypic study of atypical lymphocytes. Generated in peripheral blood and spleen of nude mice After MHV-72 infection.

scientific article

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach

scientific article published on 14 December 2006

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.

scientific article

MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.

scientific article

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

scientific article

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.

scientific article

Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets

scientific article

Megakaryocyte and polyploidization

scientific article published on 27 October 2017

Megakaryocyte polyploidization is associated with a functional gene amplification

article

Megakaryocyte polyploidization: role in platelet production

scientific article published on 22 September 2019

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.

scientific article published on May 2004

Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin

scientific article published on 01 June 2006

Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α-granules.

scientific article published in November 2017

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.

scientific article published on 21 December 2017

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.

scientific article published on 14 February 2008

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.

scientific article

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

scientific article published on 8 October 2015

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro.

scientific article

Progress in understanding the diagnosis and molecular genetics of macrothrombocytopenias

scientific article

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

scientific article

Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice

scientific article published on 19 October 2018

Regulation of megakaryocyte maturation and platelet formation.

scientific article published on July 2009

Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia

scientific article published on 28 August 2015

The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.

scientific article

The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.

scientific article published on 29 September 2016

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development

scientific article published on 29 April 2010

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.

scientific article

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation

scientific article

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

scientific article published on 14 December 2015

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

scientific article

[Fli1 haploinsufficiency underlies Paris-Trousseau thrombopenia]

scientific article published on 01 November 2004

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging

scientific article

List of works by Hana Raslova

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

A new heterozygous mutation in GP1BA gene responsible for macrothrombocytopenia

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0

CK2: a key regulator of thrombopoiesis.

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26-related Thrombocytopenia and MYH9-related diseases.

Concomitant germ-line RUNX1 and acquired ASXL1 mutations in a T-cell acute lymphoblastic leukemia.

Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.

Developmental changes in human megakaryopoiesis.

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

Eltrombopag, a potent stimulator of megakaryopoiesis.

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

Immunophenotypic study of atypical lymphocytes. Generated in peripheral blood and spleen of nude mice After MHV-72 infection.

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.

MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.

Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets

Megakaryocyte and polyploidization

Megakaryocyte polyploidization is associated with a functional gene amplification

Megakaryocyte polyploidization: role in platelet production

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.

Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin

Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α-granules.

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro.

Progress in understanding the diagnosis and molecular genetics of macrothrombocytopenias

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice

Regulation of megakaryocyte maturation and platelet formation.

Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia

The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.

The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

[Fli1 haploinsufficiency underlies Paris-Trousseau thrombopenia]

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging