List of works - Jakub Rohlena

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.

scientific article published on 7 June 2018

Anticancer drugs targeting the mitochondrial electron transport chain

scientific article published on September 2011

Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death

scientific article

Classification of mitocans, anti-cancer drugs acting on mitochondria

scientific article published on 28 July 2012

Corrigendum to: “Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy” [Free Radic Biol Med. 50 (2011) 1546–1555]

scientific article published on 29 August 2013

Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion

scientific article published on 18 September 2008

Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes

scientific article

Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents

scientific article

Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII.

scientific article published on 14 April 2007

High molecular weight forms of mammalian respiratory chain complex II

scientific article

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner

scientific article published on 18 January 2011

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

scientific article published on 14 February 2017

K-Ras and mitochondria: dangerous liaisons

scientific article

Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function

scientific article published on 7 September 2006

MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma

scientific article published on 22 April 2016

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

scientific article published on 19 June 2020

Mitochondria-driven elimination of cancer and senescent cells

scientific article published in 2019

Mitochondrial Complex II: At the Crossroads

scientific article published on 6 February 2017

Mitochondrial complex II, a novel target for anti-cancer agents ⬇️

scientific article published on November 6, 2012

Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

scientific article

Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II

scientific article

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

scientific article published on 12 March 2011

Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis

scientific article

Mitochondrially targeted α-tocopheryl succinate is antiangiogenic: potential benefit against tumor angiogenesis but caution against wound healing

scientific article

Nuclear receptor Nurr1 is expressed in and is associated with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation

scientific article published on 26 April 2010

Powerhouse down: Complex II dissociation in the respiratory chain

scientific article

Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2.

scientific article

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

scientific article published on 15 November 2018

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

scientific article published on 07 February 2020

Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein

scientific article

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer

scientific article published on 08 July 2016

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization.

scientific article

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

scientific article published on 17 February 2009

The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells

scientific article published on September 2016

The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria

scientific article published on 15 April 2016

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation

scientific article

List of works by Jakub Rohlena

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.

Anticancer drugs targeting the mitochondrial electron transport chain

Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death

Classification of mitocans, anti-cancer drugs acting on mitochondria

Corrigendum to: “Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy” [Free Radic Biol Med. 50 (2011) 1546–1555]

Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion

Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes

Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents

Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII.

High molecular weight forms of mammalian respiratory chain complex II

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

K-Ras and mitochondria: dangerous liaisons

Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function

MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

Mitochondria-driven elimination of cancer and senescent cells

Mitochondrial Complex II: At the Crossroads

Mitochondrial complex II, a novel target for anti-cancer agents ⬇️

Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis

Mitochondrially targeted α-tocopheryl succinate is antiangiogenic: potential benefit against tumor angiogenesis but caution against wound healing

Nuclear receptor Nurr1 is expressed in and is associated with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation

Powerhouse down: Complex II dissociation in the respiratory chain

Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2.

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization.

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells

The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation