List of works - Jim R Hughes

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

scientific article published on 21 June 2021

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

scientific article published on 27 November 2019

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

scientific article published in Nature Communications

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

scientific article published on 04 March 2020

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

scientific article published on 26 June 2019

DeepC: predicting 3D genome folding using megabase-scale transfer learning

scientific article published on 12 October 2020

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

scientific article published on 09 February 2022

Dynamics of the 4D genome during in vivo lineage specification and differentiation

scientific article published on 01 June 2020

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

scientific article published on 4 September 2017

Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

scientific article published on 28 September 2016

Genetic dissection of the α-globin super-enhancer in vivo

scientific article published on 04 July 2016

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

scientific article published on September 2017

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

scientific article published on 22 January 2021

How best to identify chromosomal interactions: a comparison of approaches

scientific article

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

scientific article published on 8 January 2018

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

scientific article published on 04 November 2021

Reactivation of a developmentally silenced embryonic globin gene

scientific article published on 21 July 2021

Reconstruction of the global neural crest gene regulatory network in vivo: Supplemental_Material

article

Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints.