List of works - Shehab A Ismail

A GDI/GDF-like system for sorting and shuttling ciliary proteins

scientific article published on 3 August 2016

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

scientific article

A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB.

scientific article published on 27 January 2017

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition

scientific article published on 27 September 2018

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

scientific article published on 12 March 2021

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

scientific article

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site

scientific article published on 3 November 2016

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.

scientific article published on October 2015

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

scientific article published on 24 September 2018

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

scientific article published on 05 February 2019

Identification of pyrazolopyridazinones as PDEδ inhibitors

scientific article

Maintaining protein composition in cilia

scientific article published on 28 August 2017

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

scientific article

Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives

scientific article published on 15 July 2014

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

scientific article published on 15 February 2017

Shuttling and sorting lipid-modified cargo into the cilia.

scientific article published on October 2016

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

scientific article

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

scientific article

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.

scientific article

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site

scientific article

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK

scientific article published on 13 September 2018

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

scientific article

The N- and C-terminal ends of RPGR can bind to PDE6δ.

scientific article published on 9 November 2015

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo

scientific article

The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism

scientific article

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

scientific article

List of works by Shehab A Ismail

A GDI/GDF-like system for sorting and shuttling ciliary proteins

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB.

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

Identification of pyrazolopyridazinones as PDEδ inhibitors

Maintaining protein composition in cilia

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

Shuttling and sorting lipid-modified cargo into the cilia.

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

The N- and C-terminal ends of RPGR can bind to PDE6δ.

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo

The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.