List of works - Jens Pahnke

2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells

scientific article

2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM).

scientific article published in March 2006

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE

scientific article published on 03 November 2006

32nd International Austrian Winter Symposium : Zell am See, the Netherlands. 20-23 January 2016

scientific article published on 18 April 2016

A novel sialyl Le(X) expression score as a potential prognostic tool in colorectal cancer.

scientific article

ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice

scientific article

ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier

scientific article published on 01 January 2018

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers.

scientific article published on 27 October 2017

Abstracts of the 33rd International Austrian Winter Symposium : Zell am See, Austria. 24-27 January 2018. ⬇️

scientific article

Accumulation of murine amyloid-β mimics early Alzheimer's disease.

scientific article

Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies.

scientific article published on 29 August 2015

Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET

scientific article published on 24 October 2018

Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier ⬇️

scientific article published on 19 November 2018

Alzheimer's and ABC transporters--new opportunities for diagnostics and treatment.

scientific article

Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?

scientific article published on 27 May 2009

An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy.

scientific article

August 2001: Sellar/suprasellar mass in a 59-year-old woman

scientific article published on 01 January 2002

Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI.

scientific article

Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

scientific article published on 03 November 2020

C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors

scientific article published on 16 March 2021

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

scientific article

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.

scientific article published on 5 November 2002

Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease.

scientific article published on November 2004

Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.

scientific article published on 16 March 2016

Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease

scientific article published on August 2008

DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling.

scientific article published on October 2013

Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression.

scientific article

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

scientific article published in October 2002

Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer's disease

scientific article

Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression.

scientific article

Efficient Near-Infrared In Vivo Imaging of Amyoid-β Deposits in Alzheimer's Disease Mouse Models ⬇️

scientific article published on January 1, 2012

Evaluation of systemic targeting of RET oncogene-based MTC with tumor-selective peptide-tagged Ad vectors in clinical mouse models ⬇️

scientific article published on January 13, 2011

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

scientific article published on 20 June 2017

Expressionview: visualization of quantitative trait loci and gene-expression data in Ensembl

scientific article

Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography

scientific article

French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice

scientific article published on 29 November 2018

Functionally relevant domains of the prion protein identified in vivo

scientific article

Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiation

scientific article published in July 2003

Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1flx/flx ) with Knockout Capability

scientific article published on 12 June 2019

Genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of Alzheimer's disease.

scientific article published on March 2013

Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches

scientific article published on 06 July 2018

Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.

scientific article

Impaired mitochondrial energy production and ABC transporter function-A crucial interconnection in dementing proteopathies of the brain

scientific article published on 03 September 2013

Improved method for cannula fixation for long-term intracerebral brain infusion.

scientific article

In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

scientific article

Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice

scientific article published on 01 April 2019

Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice

scientific article

Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy

scientific article published on 01 January 2021

Intrathecal large granular lymphocytes as an unusual presentation of a small cell T cell lymphoma ⬇️

scientific article published on March 14, 2012

Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche

scientific article published on 23 August 2018

K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution

scientific article published on 15 May 2018

Lethal recessive myelin toxicity of prion protein lacking its central domain

scientific article

McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement.

scientific article published in July 2003

Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis

scientific article published on 18 April 2012

Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula

scientific article published on 3 March 2016

Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene.

scientific article published on 13 August 2014

No evidence for THAP1/DYT6 variants as disease modifiers in DYT1 dystonia

scientific article published on 02 June 2011

Novel human melanoma brain metastasis models in athymic nude fox1<sup>nu</sup> mice: Site-specific metastasis patterns reflecting their clinical origin

scientific article published on 06 October 2021

Outcome of very low birthweight infants after introducing a new standard regime with the early use of nasal CPAP

scientific article published on 03 January 2008

Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells.

scientific article published on July 2004

Perfusion single photon emission computed tomography in a mouse model of neurofibromatosis type 1: towards a biomarker of neurologic deficits

scientific article published on 18 March 2015

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease

scientific article

Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study.

scientific article

Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19).

scientific article published on July 2006

Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.

scientific article

Revisiting rodent models: Octodon degus as Alzheimer's disease model?

scientific article published on 26 August 2016

Short-Term Effects of Microglia-Specific Mitochondrial Dysfunction on Amyloidosis in Transgenic Models of Alzheimer's Disease

scientific article published on 01 January 2018

Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice

scientific article published on 31 May 2016

Spinal cord pathology in chronic experimental Toxoplasma gondii infection

scientific article published on 14 March 2014

Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity.

scientific article

Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease

scientific article

Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III.

scientific article

The choroid plexus in health and in disease: dialogues into and out of the brain

scientific article

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

scientific article published on 21 July 2018

The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease

scientific article

The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease.

scientific article published on May 2004

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

scientific article

The role of blood-brain barrier in the pathogenesis of Alzheimer dementia--implications for immunological therapies for plaque dissolution

scientific article published on 14 August 2009

Transcriptome analysis in mouse tumors induced by Ret-MEN2/FMTC mutations reveals subtype-specific role in survival and interference with immune surveillance.

scientific article published on 4 November 2008

Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia.

scientific article

Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis.

scientific article

Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis.

scientific article published on April 2007

Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L: -tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat.

scientific article published on 15 March 2006

Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary.

scientific article

Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development

scientific article published in 2020

Wnt-5a expression in the rat neuronal progenitor cell line ST14A.

scientific article published on 20 April 2004

[Involvement of CNS in leukaemia and lymphomas--CSF meningeosis and immunocytochemical phenotyping]

scientific article published on 14 August 2009

List of works by Jens Pahnke

2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells

2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM).

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE

32nd International Austrian Winter Symposium : Zell am See, the Netherlands. 20-23 January 2016

A novel sialyl Le(X) expression score as a potential prognostic tool in colorectal cancer.

ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice

ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers.

Abstracts of the 33rd International Austrian Winter Symposium : Zell am See, Austria. 24-27 January 2018. ⬇️

Accumulation of murine amyloid-β mimics early Alzheimer's disease.

Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies.

Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET

Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier ⬇️

Alzheimer's and ABC transporters--new opportunities for diagnostics and treatment.

Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?

An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy.

August 2001: Sellar/suprasellar mass in a 59-year-old woman

Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI.

Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.

Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease.

Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.

Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease

DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling.

Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression.

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer's disease

Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression.

Efficient Near-Infrared In Vivo Imaging of Amyoid-β Deposits in Alzheimer's Disease Mouse Models ⬇️

Evaluation of systemic targeting of RET oncogene-based MTC with tumor-selective peptide-tagged Ad vectors in clinical mouse models ⬇️

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Expressionview: visualization of quantitative trait loci and gene-expression data in Ensembl

Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography

French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice

Functionally relevant domains of the prion protein identified in vivo

Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiation

Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1flx/flx ) with Knockout Capability

Genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of Alzheimer's disease.

Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches

Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.

Impaired mitochondrial energy production and ABC transporter function-A crucial interconnection in dementing proteopathies of the brain

Improved method for cannula fixation for long-term intracerebral brain infusion.

In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice

Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice

Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy

Intrathecal large granular lymphocytes as an unusual presentation of a small cell T cell lymphoma ⬇️

Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche

K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution

Lethal recessive myelin toxicity of prion protein lacking its central domain

McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement.

Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis

Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula

Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene.

No evidence for THAP1/DYT6 variants as disease modifiers in DYT1 dystonia

Novel human melanoma brain metastasis models in athymic nude fox1<sup>nu</sup> mice: Site-specific metastasis patterns reflecting their clinical origin

Outcome of very low birthweight infants after introducing a new standard regime with the early use of nasal CPAP

Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells.

Perfusion single photon emission computed tomography in a mouse model of neurofibromatosis type 1: towards a biomarker of neurologic deficits

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease

Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study.

Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19).

Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.

Revisiting rodent models: Octodon degus as Alzheimer's disease model?

Short-Term Effects of Microglia-Specific Mitochondrial Dysfunction on Amyloidosis in Transgenic Models of Alzheimer's Disease

Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice

Spinal cord pathology in chronic experimental Toxoplasma gondii infection

Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity.

Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease

Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III.

The choroid plexus in health and in disease: dialogues into and out of the brain

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease

The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease.

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

The role of blood-brain barrier in the pathogenesis of Alzheimer dementia--implications for immunological therapies for plaque dissolution

Transcriptome analysis in mouse tumors induced by Ret-MEN2/FMTC mutations reveals subtype-specific role in survival and interference with immune surveillance.