List of works by Darren J Kelly

3',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy.

scientific article published on 8 October 2013

3',4'-Dihydroxyflavonol antioxidant attenuates diastolic dysfunction and cardiac remodeling in streptozotocin-induced diabetic m(Ren2)27 rats

scientific article

A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction

scientific article published on 06 December 2012

A purpose-synthesised anti-fibrotic agent attenuates experimental kidney diseases in the rat

scientific article

Adrenaline cells of the rat adrenal cortex and medulla contain renin and prorenin

scientific article published on 01 May 1996

Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?

scientific article published on 6 June 2007

Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart

scientific article published in September 2011

Angiotensin II-induced proteinuria and expression of the podocyte slit pore membrane protein, nephrin

scientific article published on 01 January 2004

Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes

scientific article published on 01 November 2000

Atrial Remodeling in an Ovine Model of Anthracycline-Induced Nonischemic Cardiomyopathy: Remodeling of the Same Sort

scientific article published on 01 February 2011

Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing

scientific article

Atrial protective effects of n-3 polyunsaturated fatty acids: a long-term study in ovine chronic heart failure

scientific article published on 08 December 2010

Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011

scientific article published on 16 December 2012

BK virus RNA can be detected in archival renal transplant biopsies using the reverse trancription polymerase chain reaction.

scientific article published on 04 December 2008

COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity

scientific article published in March 2003

Cannabinoid receptor 2 expression in human proximal tubule cells is regulated by albumin independent of ERK1/2 signaling

scientific article published on 22 November 2013

Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart

scientific article published on 16 July 2015

Cardiac fibrosis in the ageing heart: contributors and mechanisms.

scientific article published on 18 March 2017

Cells expressing the stem cell factor receptor, c-kit, contribute to neoangiogenesis in diabetes

scientific article published in May 2005

Characterization of cardiac remodeling in a large animal "one-kidney, one-clip" hypertensive model

scientific article published in April 2010

Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis

scientific article published on 13 January 2015

Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats

scientific article

Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy.

scientific article

Clinically relevant models of diabetic cardiac complications

scientific article published on 01 September 2007

Contribution of microRNA to pathological fibrosis in cardio-renal syndrome: impact of uremic toxins

scientific article published on April 2015

Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism

scientific article (publication date: 2010)

Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels

scientific article

Differences in myocardial structure and coronary microvasculature between men and women with coronary artery disease

scientific article published on 06 December 2010

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

scientific article published in 2021

Dynamic synchrotron imaging of diabetic rat coronary microcirculation in vivo

scientific article published on 10 November 2011

Early and delayed tranilast treatment reduces pathological fibrosis following myocardial infarction.

scientific article

Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction.

scientific article published on 22 April 2009

Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat

scientific article published on 01 May 2000

Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy

scientific article published on 23 May 2007

Elevated cannabinoid receptor 1 and G protein-coupled receptor 55 expression in proximal tubule cells and whole kidney exposed to diabetic conditions.

scientific article

Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates

scientific article published on 7 October 2009

Expression, localization, and function of the thioredoxin system in diabetic nephropathy

scientific article published on 11 February 2009

FT011, a Novel Cardiorenal Protective Drug, Reduces Inflammation, Gliosis and Vascular Injury in Rats with Diabetic Retinopathy

scientific article

FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy

scientific article published on 14 March 2012

FT23, an orally active antifibrotic compound, attenuates structural and functional abnormalities in an experimental model of diabetic cardiomyopathy

scientific article published in August 2012

Fas-induced apoptosis is a feature of progressive diabetic nephropathy in transgenic (mRen-2)27 rats: attenuation with renin-angiotensin blockade

scientific article published in February 2004

Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease

scientific article

Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat

scientific article published on 29 June 2007

High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway.

scientific article published on 25 July 2008

High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

scientific article

High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism

scientific article

High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1.

scientific article

Hypertension and atrial fibrillation: evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model

scientific article published on 11 May 2010

Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease

scientific article

Impaired cardiac anti-oxidant activity in diabetes: human and correlative experimental studies

scientific article published on 13 June 2014

In vivo visualization of albumin degradation in the proximal tubule

scientific article published on 17 September 2008

Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy

scientific article published on 01 November 2004

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

scientific article published on 01 August 2005

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy

scientific article published on 10 February 2009

Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy

scientific article

Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy

scientific article published on 01 January 2003

Macrophage infiltration and cellular proliferation in the non-ischemic kidney and heart following prolonged unilateral renal ischemia

scientific article published on 15 June 2007

Mast cell infiltration and chemokine expression in progressive renal disease

scientific article published in September 2003

Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome

scientific article published on 24 February 2012

Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis.

scientific article published on 22 December 2004

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome

scientific article published on 18 April 2018

Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation

scientific article published on 01 September 2012

PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis.

scientific article published on April 2001

Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats.

scientific article published on 25 September 2008

Platelet-derived growth factor receptor transactivation mediates the trophic effects of angiotensin II in vivo.

scientific article

Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension

scientific article published in February 2003

Protein kinase C β inhibition ameliorates experimental mesangial proliferative glomerulonephritis.

scientific article published on September 2011

Protein kinase C-beta inhibition attenuates the progression of nephropathy in non-diabetic kidney disease

scientific article published on 20 January 2009

Protein kinase Cbeta inhibition attenuates osteopontin expression, macrophage recruitment, and tubulointerstitial injury in advanced experimental diabetic nephropathy

scientific article published on 20 April 2005

Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations.

scientific article

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

scientific article published on 03 April 2008

Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy

scientific article

Renal expression of transforming growth factor-β inducible gene-h3 (βig-h3) in normal and diabetic rats11See Editorial by Border and Noble, p. 1390

article

Renin inhibition: new potential for an old therapeutic target

scientific article published on 15 August 2005

Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells

scientific article published on 27 August 2008

Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions

scholarly article

Role of the eNOS-NO system in regulating the antiproteinuric effects of VEGF receptor 2 inhibition in diabetes

scientific article published on 22 August 2013

SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity

scientific journal article

Short-term hypertension is associated with the development of atrial fibrillation substrate: a study in an ovine hypertensive model.

scientific article published on 2 December 2009

Soluble epoxide hydrolase inhibition exerts beneficial anti-remodeling actions post-myocardial infarction

scientific article published on 10 January 2012

Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction

scientific article published on 12 February 2010

The anti-fibrotic hormone relaxin is not reno-protective, despite being active, in an experimental model of type 1 diabetes

scientific article published on 01 September 2013

The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1.

scientific article published on June 2007

The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-γ in the regulation of macrophage inflammatory protein-3α at early onset of diabetes

scientific article published on November 23, 2010

The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction

scientific article

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway.

scientific article published on 06 July 2016

Thioredoxin-interacting protein: a potential therapeutic target for treatment of progressive fibrosis in diabetic nephropathy.

scientific article

Tranilast ameliorates experimental mesangial proliferative glomerulonephritis

scientific article published on 15 May 2008

Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta

scientific article published in February 2005

Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy

scientific article published on 24 August 2007

Tranilast attenuates structural and functional aspects of renal injury in the remnant kidney model

scientific article published in October 2004

Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy.

scientific article published on 23 June 2010

Transforming growth factor-beta in human diabetic nephropathy: effects of ACE inhibition.

scientific article

Vasoactive renal factors and the progression of diabetic nephropathy.

scientific article

Vitamin D(2) supplementation induces the development of aortic stenosis in rabbits: interactions with endothelial function and thioredoxin-interacting protein.

scientific article published on 12 June 2008

Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model

scientific article published on 22 December 2017