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List of works by Anne Grapin-Botton

A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion

scientific article published on 25 May 2021

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

scientific article

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

scientific article

Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity

scientific article published on 01 May 2020

Artificial three-dimensional niches deconstruct pancreas development in vitro.

scientific article

At new heights - endodermal lineages in development and disease

scientific article

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

scientific article published on 01 March 2015

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

scientific article published on 01 January 2016

Bromodomain and Extra Terminal Protein Inhibitors Promote Pancreatic Endocrine Cell Fate

scientific article published on 17 January 2019

COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways

scientific article

Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas

scientific article (publication date: March 2015)

Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers.

scientific article published on 19 May 2015

Concise reviews: In vitro-produced pancreas organogenesis models in three dimensions: self-organization from few stem cells or progenitors.

scientific article

Deconstructing the principles of ductal network formation in the pancreas.

scientific article published on 26 July 2018

Defined concentrations of a posteriorizing signal are critical for MafB/Kreisler segmental expression in the hindbrain ⬇️

scientific article published on April 1, 1998

Determination of the identity of the derivatives of the cephalic neural crest: incompatibility between Hox gene expression and lower jaw development ⬇️

scientific article published on September 1, 1998

Development and diseases of the pancreas

scientific article

Diabetes imaging-quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

scientific article

Distribution of HOX genes in the chicken genome reveals a new segment of conservation between human and chicken

scientific article published on 01 January 2001

Dominant and context-specific control of endodermal organ allocation by Ptf1a ⬇️

scientific article

Dual lineage-specific expression of Sox17 during mouse embryogenesis.

scientific article published on October 2012

Ductal cells of the pancreas.

scientific article

Endoderm specification

scientific article published on 9 July 2010

Evolution of the mechanisms and molecular control of endoderm formation

scientific article published on 11 January 2007

FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo

scientific article published on 2 December 2005

Genetic control of rhombencephalon development by Hox genes studied in bird embryo by the quail-chick chimera method

scientific article published in January 1997

Hox gene induction in the neural tube depends on three parameters: competence, signal supply and paralogue group.

scientific article published in February 1997

Improved Differentiation of hESC-Derived Pancreatic Progenitors by Using Human Fetal Pancreatic Mesenchymal Cells in a Micro‐scalable Three-Dimensional Co-culture System

In vitro pancreas organogenesis from dispersed mouse embryonic progenitors

scientific article

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy.

scientific article published on 30 May 2009

Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine

scientific article published on 20 June 2018

Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes

scientific article

Label-free fast 3D coherent imaging reveals pancreatic islet micro-vascularization and dynamic blood flow.

scientific article published on 17 October 2016

Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging

scientific article published on 27 November 2015

Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development.

scientific article published on February 2011

Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment

scientific article published on 29 January 2013

Nutrients men-TOR β-Cells to Adulthood

scientific article published on 01 July 2020

Pairing-up SOX to kick-start beta cell genesis.

scientific article

Pancreas development and cancer: Wnt/beta-catenin at issue...

scientific article published on 4 January 2006

Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.

scientific article published in September 2005

Parsing the Pancreas

scientific article published on 01 March 2017

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice

scientific article published on 10 August 2012

Patterning and shaping the endoderm in vivo and in culture

scientific article published on 27 June 2012

Patterning signals acting in the spinal cord override the organizing activity of the isthmus.

scientific article published in June 1999

Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.

scientific article published on 21 November 2012

Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications

scientific article published on 01 September 1995

REST represses a subset of the pancreatic endocrine differentiation program.

scientific article published on 5 July 2015

RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors

scientific journal article

Recapitulating and Deciphering Human Pancreas Development From Human Pluripotent Stem Cells in a Dish

scientific article published on 08 May 2018

Regeneration of the pancreas: proliferation and cellular conversion of surviving cells

scientific article published on 25 July 2020

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis

scientific article

Self-organization of organoids from endoderm-derived cells

scientific article published on 22 November 2020

Short-range growth inhibitory signals from the epithelium can drive non-stereotypic branching in the pancreas

scientific article published on 23 February 2016

Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate

scientific article

Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation

scientific article published on 8 September 2017

Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis

scientific article published on 19 September 2017

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.

scientific article

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

scientific article published on 19 December 2017

The Importance of REST for Development and Function of Beta Cells

scientific article published on 24 February 2017

The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj downstream target that suppresses glutamatergic and promotes GABAergic neuronal fate in the dorsal neural tube

scientific journal article

The avian fli gene is specifically expressed during embryogenesis in a subset of neural crest cells giving rise to mesenchyme.

scientific article published in May 1998

The expression pattern of the mafB/kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant.

scientific article published in July 1997

The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo ⬇️

scientific article published on July 1, 1998

The genetic programme of pancreatic beta-cells: basic science for the development of beta-cell therapy. Workshop on programming pancreatic beta-cells

scientific article published on 16 March 2007

The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation.

scientific article published on 12 April 2013

The molecular and morphogenetic basis of pancreas organogenesis

scientific article published on 12 January 2017

The physics of organoids: a biophysical approach to understanding organogenesis.

scientific article published on March 2017

The regeneration of the cephalic neural crest, a problem revisited: the regenerating cells originate from the contralateral or from the anterior and posterior neural fold.

scientific article

Three-dimensional pancreas organogenesis models.

scientific article published on September 2016

Towards high resolution optical imaging of beta cells in vivo.

scientific article published on May 2010

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

scientific article

Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling

scientific article published on 15 August 2018

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