List of works - Paola Fadda

An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives.

scientific article published on 12 July 2006

Analysis of opioid-seeking reinstatement in the rat.

scientific article published in January 2015

Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat

scientific journal article

Behavioural and neurochemical assessment of salvinorin A abuse potential in the rat.

scientific article published on 13 June 2014

Benzocondensed derivatives as rigid analogues of the mu-opioid agonist 3(8)-cinnamyl-8(3)-propionyl-3,8-diazabicyclo[3.2.1]octanes: synthesis, modeling, and affinity.

scientific article

Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2.

scientific article

Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors

scientific journal article

CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat

scientific article

Cannabinoid CB1 /CB2 receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity-based anorexia.

scientific article published on 31 May 2017

Cannabinoid self-administration increases dopamine release in the nucleus accumbens.

scientific article published in October 2006

Cannabinoid-opioid interactions in drug discrimination and self-administration: effect of maternal, postnatal, adolescent and adult exposure to the drugs.

scientific article published on April 2010

Cannabinoids and reward: interactions with the opioid system.

scientific article

Chronic blockade of CB(1) receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation

scientific article

Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult rats.

scientific article published on 19 August 2012

Chronic imipramine, L-sulpiride and mianserin decrease corticotropin releasing factor levels in the rat brain

scientific article published on 01 June 1995

Differential effect of opioid and cannabinoid receptor blockade on heroin-seeking reinstatement and cannabinoid substitution in heroin-abstinent rats.

scientific article

Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats

scientific article published in December 2004

Dopamine D1 and opioid receptor binding changes in the limbic system of sleep deprived rats.

scientific article published in March 1992

Dopamine and opioids interactions in sleep deprivation.

scientific article published in March 1993

Drug- and cue-induced reinstatement of cannabinoid-seeking behaviour in male and female rats: influence of ovarian hormones.

scientific article

Endocannabinoid system and opioid addiction: behavioural aspects.

scientific article

Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms

scientific article

Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa

scientific article published on 10 April 2020

Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats

scientific article published on 25 August 2008

Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward

scientific article

Long-term reduction of brain-derived neurotrophic factor levels and signaling impairment following prenatal treatment with the cannabinoid receptor 1 receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl) pyrrolo[1,2,3-de]-1,4-benzo

scientific article

Male and female rats differ in brain cannabinoid CB1 receptor density and function and in behavioural traits predisposing to drug addiction: effect of ovarian hormones.

scientific article

Methoxetamine affects brain processing involved in emotional response in rats.

scientific article published on 18 July 2017

Monocyclic analogues of the μ-opioid agonist 3,8-diazabicyclo [3.2.1]octanes: Synthesis, modeling, and activity

N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes as mu-opioid receptor agonists. Effects on mu-affinity of arylalkenyl chain modifications.

scientific article

Neurobiological mechanisms of cannabinoid addiction.

scientific article published on 16 February 2008

PPARα regulates cholinergic-driven activity of midbrain dopamine neurons via a novel mechanism involving α7 nicotinic acetylcholine receptors.

scientific article

Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats.

scientific article published on June 2013

Reduction of corticostriatal glutamatergic fibers in basic fibroblast growth factor deficient mice is associated with hyperactivity and enhanced dopaminergic transmission.

scientific article published on 8 December 2006

Role of opioid receptors in the reinstatement of opioid-seeking behavior: an overview

scientific article published on January 2015

Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts.

scientific article published on 6 January 2006

Sex differences in addictive disorders

scientific article published on 21 April 2014

Sex differences in the self-administration of cannabinoids and other drugs of abuse.

scientific article published on December 2009

Strain and schedule-dependent differences in the acquisition, maintenance and extinction of intravenous cannabinoid self-administration in rats.

scientific article published on 13 November 2006

Stress-induced sleep deprivation modifies corticotropin releasing factor (CRF) levels and CRF binding in rat brain and pituitary.

scientific article published in May 1997

Synthesis and mu-opioid receptor affinity of a new series of nitro substituted 3,8-diazabicyclo[3.2.1]octane derivatives.

scientific article

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats

scientific article

The endocannabinoid system: a new molecular target for the treatment of tobacco addiction.

scientific article

The role of the endocannabinoid system in eating disorders: neurochemical and behavioural preclinical evidence.

scientific article published on 09 July 2013

Δ9-tetrahydrocannabinol prevents methamphetamine-induced neurotoxicity

scientific article

List of works by Paola Fadda

An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives.

Analysis of opioid-seeking reinstatement in the rat.

Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat

Behavioural and neurochemical assessment of salvinorin A abuse potential in the rat.

Benzocondensed derivatives as rigid analogues of the mu-opioid agonist 3(8)-cinnamyl-8(3)-propionyl-3,8-diazabicyclo[3.2.1]octanes: synthesis, modeling, and affinity.

Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2.

Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors

CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat

Cannabinoid CB1 /CB2 receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity-based anorexia.

Cannabinoid self-administration increases dopamine release in the nucleus accumbens.

Cannabinoid-opioid interactions in drug discrimination and self-administration: effect of maternal, postnatal, adolescent and adult exposure to the drugs.

Cannabinoids and reward: interactions with the opioid system.

Chronic blockade of CB(1) receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation

Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult rats.

Chronic imipramine, L-sulpiride and mianserin decrease corticotropin releasing factor levels in the rat brain

Differential effect of opioid and cannabinoid receptor blockade on heroin-seeking reinstatement and cannabinoid substitution in heroin-abstinent rats.

Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats

Dopamine D1 and opioid receptor binding changes in the limbic system of sleep deprived rats.

Dopamine and opioids interactions in sleep deprivation.

Drug- and cue-induced reinstatement of cannabinoid-seeking behaviour in male and female rats: influence of ovarian hormones.

Endocannabinoid system and opioid addiction: behavioural aspects.

Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms

Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa

Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats

Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward

Long-term reduction of brain-derived neurotrophic factor levels and signaling impairment following prenatal treatment with the cannabinoid receptor 1 receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl) pyrrolo[1,2,3-de]-1,4-benzo

Male and female rats differ in brain cannabinoid CB1 receptor density and function and in behavioural traits predisposing to drug addiction: effect of ovarian hormones.

Methoxetamine affects brain processing involved in emotional response in rats.

Monocyclic analogues of the μ-opioid agonist 3,8-diazabicyclo [3.2.1]octanes: Synthesis, modeling, and activity

N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes as mu-opioid receptor agonists. Effects on mu-affinity of arylalkenyl chain modifications.

Neurobiological mechanisms of cannabinoid addiction.

PPARα regulates cholinergic-driven activity of midbrain dopamine neurons via a novel mechanism involving α7 nicotinic acetylcholine receptors.

Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats.

Reduction of corticostriatal glutamatergic fibers in basic fibroblast growth factor deficient mice is associated with hyperactivity and enhanced dopaminergic transmission.

Role of opioid receptors in the reinstatement of opioid-seeking behavior: an overview

Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts.

Sex differences in addictive disorders

Sex differences in the self-administration of cannabinoids and other drugs of abuse.

Strain and schedule-dependent differences in the acquisition, maintenance and extinction of intravenous cannabinoid self-administration in rats.

Stress-induced sleep deprivation modifies corticotropin releasing factor (CRF) levels and CRF binding in rat brain and pituitary.

Synthesis and mu-opioid receptor affinity of a new series of nitro substituted 3,8-diazabicyclo[3.2.1]octane derivatives.

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats

The endocannabinoid system: a new molecular target for the treatment of tobacco addiction.

The role of the endocannabinoid system in eating disorders: neurochemical and behavioural preclinical evidence.

Δ9-tetrahydrocannabinol prevents methamphetamine-induced neurotoxicity