List of works - Giuseppe Verdile

A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer's Disease

scientific article published on 19 December 2018

A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly

scientific article

A zebrafish melanophore model of amyloid beta toxicity

scientific article

Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies.

scientific article published in January 2018

Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity.

scientific article published on 26 March 2015

Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.

scientific article published in February 2004

Amyloid-β and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model.

scientific article published on 14 August 2017

Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease

scientific article published on 20 August 2008

Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease.

scientific article published on 23 October 2012

Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.

scientific article published on June 2004

Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults.

scientific article published on 31 March 2016

Cerebral amyloid-β accumulation and deposition following traumatic brain injury--A narrative review and meta-analysis of animal studies

scientific article published on 17 February 2016

Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests.

scientific article published on 16 September 2008

Clearing the amyloid in Alzheimer's: progress towards earlier diagnosis and effective treatments - an update for clinicians.

scientific article

Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study

scientific article

Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity

scientific article published on 20 January 2008

Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease

scientific article published on 18 September 2013

Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease

scientific article published on 13 August 2018

Effect of chronic hCG administration on Alzheimer's-related cognition and A beta accumulation in PS1KI mice.

scientific article published on 15 September 2010

Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice.

scientific article

Efficient production of a mature and functional gamma secretase protease

scientific article published in Scientific Reports

Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline

scientific article published on 14 January 2017

Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.

scientific article published on 4 April 2016

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease.

scientific article

Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts.

scientific article

Immunization in Alzheimer's disease: naïve hope or realistic clinical potential?

scientific article published on 28 October 2008

Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner.

scientific article published on 03 April 2017

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.

scientific article published on 27 June 2009

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease

scientific article

Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.

scientific article published on 29 August 2017

Is cholesterol and amyloid-β stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147.

scientific article

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

scientific article published in February 2018

Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease

scientific article published on 06 January 2019

Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.

scientific article published on January 2012

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

scientific article published on 31 July 2012

Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer's and other neurodegenerative diseases

scientific article published on 03 December 2013

Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition

scientific article

Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier.

scientific article published on 22 June 2017

New lexicon and criteria for the diagnosis of Alzheimer's disease

scientific article published on 01 April 2011

Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity.

scientific article

Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI.

scientific article

Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: quod erat demonstrandum?

scientific article published on 9 October 2009

Regular care and maintenance of a zebrafish (Danio rerio) laboratory: an introduction.

scientific article

Research criteria for the diagnosis of Alzheimer's disease: genetic risk factors, blood biomarkers and olfactory dysfunction

scientific article published on 17 April 2008

Testosterone replacement therapy in older male subjective memory complainers: double-blind randomized crossover placebo-controlled clinical trial of physiological assessment and safety

scientific article published in January 2015

The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity

scientific article published on 22 January 2016

The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes

scientific article

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

scientific article published on March 2017

The dynamics of CD147 in Alzheimer's disease development and pathology.

scientific article published on January 2011

The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies.

scientific article published on 26 June 2015

The role of gonadotropins in Alzheimer's disease: potential neurodegenerative mechanisms.

scientific article published on April 2006

The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid

scientific article published on 31 August 2006

The role of type 2 diabetes in neurodegeneration

scientific article published on 26 April 2015

The structure and function of Alzheimer's gamma secretase enzyme complex.

scientific article published on January 2009

Utility of an Alzheimer's Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer's Disease: A Prospective Longitudinal Study

scientific article published on 01 January 2018

Validation and Characterization of a Novel Peptide That Binds Monomeric and Aggregated β-Amyloid and Inhibits the Formation of Neurotoxic Oligomers

scientific article

Zebrafish as a tool in Alzheimer's disease research.

scientific article published on 12 October 2010

val158met is not associated with Aβ-amyloid and ε4 related cognitive decline in cognitively normal older adults ⬇️

scientific article published on 02 May 2019

List of works by Giuseppe Verdile

A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer's Disease

A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly

A zebrafish melanophore model of amyloid beta toxicity

Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies.

Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity.

Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.

Amyloid-β and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model.

Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease

Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease.

Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.

Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults.

Cerebral amyloid-β accumulation and deposition following traumatic brain injury--A narrative review and meta-analysis of animal studies

Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests.

Clearing the amyloid in Alzheimer's: progress towards earlier diagnosis and effective treatments - an update for clinicians.

Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study

Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity

Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease

Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease

Effect of chronic hCG administration on Alzheimer's-related cognition and A beta accumulation in PS1KI mice.

Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice.

Efficient production of a mature and functional gamma secretase protease

Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline

Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease.

Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts.

Immunization in Alzheimer's disease: naïve hope or realistic clinical potential?

Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner.

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease

Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.

Is cholesterol and amyloid-β stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147.

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease

Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer's and other neurodegenerative diseases

Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition

Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier.

New lexicon and criteria for the diagnosis of Alzheimer's disease

Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity.

Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI.

Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: quod erat demonstrandum?

Regular care and maintenance of a zebrafish (Danio rerio) laboratory: an introduction.

Research criteria for the diagnosis of Alzheimer's disease: genetic risk factors, blood biomarkers and olfactory dysfunction

Testosterone replacement therapy in older male subjective memory complainers: double-blind randomized crossover placebo-controlled clinical trial of physiological assessment and safety

The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity

The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

The dynamics of CD147 in Alzheimer's disease development and pathology.

The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies.

The role of gonadotropins in Alzheimer's disease: potential neurodegenerative mechanisms.

The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid

The role of type 2 diabetes in neurodegeneration

The structure and function of Alzheimer's gamma secretase enzyme complex.

Utility of an Alzheimer's Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer's Disease: A Prospective Longitudinal Study

Validation and Characterization of a Novel Peptide That Binds Monomeric and Aggregated β-Amyloid and Inhibits the Formation of Neurotoxic Oligomers

Zebrafish as a tool in Alzheimer's disease research.

val158met is not associated with Aβ-amyloid and ε4 related cognitive decline in cognitively normal older adults ⬇️