List of works - Keizō Takao

Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism

scientific article

Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice

scientific article

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

scientific article

Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.

scientific article published on 5 October 2017

Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders

scientific article

Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits

scientific article

Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex

scientific article published on 7 November 2017

Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age

scientific article

Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

scientific article

Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice

scientific article published on 02 January 2019

Autonomous functionality of an upstream open reading frame in polycistronic mammalian mRNAs

Behavioral abnormalities observed in Zfhx2-deficient mice

scientific article

Behavioral profiles of three C57BL/6 substrains

scientific article

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice

scientific article published on 23 March 2021

Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice

scientific article

Cohort Removal Induces Changes in Body Temperature, Pain Sensitivity, and Anxiety-Like Behavior

scientific article published on 03 June 2016

Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice

scientific article published on 11 July 2017

Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2

scientific article published on 24 November 2018

Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty

scientific article

Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice

scientific article

Comprehensive behavioral analysis of cluster of differentiation 47 knockout mice

scientific article

Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice

scientific article published on 19 July 2019

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice

scientific article

Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory

scientific article

Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2 ) knockout mice

scientific article published on 15 March 2018

Comprehensive behavioral phenotyping of calpastatin-knockout mice

scientific article

Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests.

scientific article

Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes

scientific article

Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive function

scientific article published on November 2010

Contextual and cued fear conditioning test using a video analyzing system in mice

scientific article

Correction: Synaptic E3 Ligase SCRAPPER in Contextual Fear Conditioning: Extensive Behavioral Phenotyping of Scrapper Heterozygote and Overexpressing Mutant Mice

scientific article published in PLoS ONE

DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

scientific article published on 21 October 2011

DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles

scientific article published on 8 February 2012

Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior

scientific article

Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling

scientific article

Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.

scientific article

Dissociated Role of D-Serine in Extinction During Consolidation vs. Reconsolidation of Context Conditioned Fear.

scientific article published on 22 May 2018

Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery

scientific article published on 25 October 2018

Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

scientific article published on 7 August 2016

ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response

scientific article

Effects of chronic fentanyl administration on behavioral characteristics of mice

scientific article published on 01 December 2018

Elevated plus maze for mice

scientific article published on 22 December 2008

Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus

scientific article

Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex

Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus.

scientific article

Forebrain-specific constitutively active CaMKKα transgenic mice show deficits in hippocampus-dependent long-term memory.

scientific article published on May 2011

Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes

scientific article published in September 2007

Genomic responses in mouse models greatly mimic human inflammatory diseases

scientific article

Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine

scientific article published on 02 June 2016

IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours

scientific article

Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia

scientific article published on 24 July 2008

Immature dentate gyrus: an endophenotype of neuropsychiatric disorders.

scientific article published on 12 June 2013

Impact of brain-behavior phenotypying of genetically-engineered mice on research of neuropsychiatric disorders

scientific article published on 20 February 2007

Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia

scientific article

Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice

scientific article

Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors

scientific journal article

Increased astrocytic ATP release results in enhanced excitability of the hippocampus

scientific article published on 27 September 2012

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly

scientific article

Intrauterine environment-genome interaction and children's development (4): Brain-behavior phenotypying of genetically-engineered mice using a comprehensive behavioral test battery on research of neuropsychiatric disorders

scientific article published on January 2009

Investigating gene-to-behavior pathways in psychiatric disorders: the use of a comprehensive behavioral test battery on genetically engineered mice

scientific article published on November 2006

Investigating genes-to-behavior pathways in psychiatric diseases: an approach using a comprehensive behavioral test battery on genetically engineered mice

scientific article published in June 2008

Ionic basis of cold receptors acting as thermostats.

scientific article

KF-1 Ubiquitin Ligase: An Anxiety Suppressor

scientific article published on May 2009

Light/dark transition test for mice

scientific article published on 13 November 2006

Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring's overeating in mice

scientific article published on 28 August 2020

Mechanisms for interferon-α-induced depression and neural stem cell dysfunction.

scientific article

Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition

scientific article published on 27 December 2013

Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior

scientific article

Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities.

scientific article published in July 2009

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice

scientific article published on 31 July 2017

Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system

scientific article published in December 2009

Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice

scientific article published on 24 March 2020

Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice

scientific article published on 02 September 2009

Normal mitochondrial respiratory function is essential for spatial remote memory in mice

scientific article published on 16 December 2008

Open source code for behavior analysis in rodents

scientific article published on 18 January 2019

P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating

scientific article

PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders

scientific article

Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity

scientific article published on 17 October 2013

Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly

scientific article

Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis.

scientific article published on 25 January 2017

QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior.

scientific article

Rapid and high-efficient generation of mutant mice using freeze-thawed embryos of the C57BL/6J strain

scientific article published on 23 January 2019

Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior

scientific article

Reply to Warren et al. and Shay et al.: Commonalities across species do exist and are potentially important

scientific article published on 24 December 2014

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.

scientific article published on 31 August 2008

SDOP-DB: a comparative standardized-protocol database for mouse phenotypic analyses

scientific article

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

scientific article

Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test

scientific article published on August 2010

Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice

scientific article

Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice

scientific article

T-maze forced alternation and left-right discrimination tasks for assessing working and reference memory in mice

scientific article

TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility

scientific article published on 28 September 2018

TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior

scientific article published on 8 August 2015

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia

scientific article

Targeting quantum dots to surface proteins in living cells with biotin ligase

scientific article

The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice

scientific article

Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia.

scientific article

Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.

scientific article

[Genes, behaviors and psychiatric disorders]

scientific article published on 01 March 2008

List of works by Keizō Takao

Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism

Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.

Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders

Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits

Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex

Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age

Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice

Autonomous functionality of an upstream open reading frame in polycistronic mammalian mRNAs

Behavioral abnormalities observed in Zfhx2-deficient mice

Behavioral profiles of three C57BL/6 substrains

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice

Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice

Cohort Removal Induces Changes in Body Temperature, Pain Sensitivity, and Anxiety-Like Behavior

Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice

Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2

Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty

Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice

Comprehensive behavioral analysis of cluster of differentiation 47 knockout mice

Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice

Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory

Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2 ) knockout mice

Comprehensive behavioral phenotyping of calpastatin-knockout mice

Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests.

Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes

Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive function

Contextual and cued fear conditioning test using a video analyzing system in mice

Correction: Synaptic E3 Ligase SCRAPPER in Contextual Fear Conditioning: Extensive Behavioral Phenotyping of Scrapper Heterozygote and Overexpressing Mutant Mice

DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles

Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior

Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling

Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.

Dissociated Role of D-Serine in Extinction During Consolidation vs. Reconsolidation of Context Conditioned Fear.

Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery

Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response

Effects of chronic fentanyl administration on behavioral characteristics of mice

Elevated plus maze for mice

Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus

Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex

Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus.

Forebrain-specific constitutively active CaMKKα transgenic mice show deficits in hippocampus-dependent long-term memory.

Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes

Genomic responses in mouse models greatly mimic human inflammatory diseases

Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine

IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours

Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia

Immature dentate gyrus: an endophenotype of neuropsychiatric disorders.

Impact of brain-behavior phenotypying of genetically-engineered mice on research of neuropsychiatric disorders

Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia

Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice

Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors

Increased astrocytic ATP release results in enhanced excitability of the hippocampus

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly

Intrauterine environment-genome interaction and children's development (4): Brain-behavior phenotypying of genetically-engineered mice using a comprehensive behavioral test battery on research of neuropsychiatric disorders

Investigating gene-to-behavior pathways in psychiatric disorders: the use of a comprehensive behavioral test battery on genetically engineered mice

Investigating genes-to-behavior pathways in psychiatric diseases: an approach using a comprehensive behavioral test battery on genetically engineered mice

Ionic basis of cold receptors acting as thermostats.

KF-1 Ubiquitin Ligase: An Anxiety Suppressor

Light/dark transition test for mice

Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring's overeating in mice

Mechanisms for interferon-α-induced depression and neural stem cell dysfunction.

Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition

Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior

Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities.

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice

Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system

Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice

Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice

Normal mitochondrial respiratory function is essential for spatial remote memory in mice

Open source code for behavior analysis in rodents

P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating

PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders

Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity

Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly