List of works - Kimberly Stegmaier

A first-generation pediatric cancer dependency map

scientific article published on 22 March 2021

A method for high-throughput gene expression signature analysis

scientific article published on January 2006

A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia

scientific article

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

scientific article

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

scientific article published in 2022

Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regu

scientific article

Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia

scientific article published on 6 March 2018

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

scientific article

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase

scientific article published on 6 July 2017

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer

scientific article published on 21 February 2013

Contributors

Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML

scientific article published on 02 November 2018

EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.

scientific article

Erratum: Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia

article

Evaluation of Improved Glycogen Synthase Kinase-3α Inhibitors in Models of Acute Myeloid Leukemia

scientific article published on 23 October 2015

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

scientific article

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

scientific article

Gefitinib induces myeloid differentiation of acute myeloid leukemia

scientific article published on 5 July 2005

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

scientific article published on 28 September 2006

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma

scientific article published on 25 July 2018

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

scientific article published on 3 June 2016

Genomic approaches in acute leukemia

scientific article

High-throughput gene expression profiling of memory differentiation in primary human T cells

scientific article

High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma

scientific article published on 27 March 2013

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia

scientific article

Identification of AML1-ETO modulators by chemical genomics

scientific article

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

scientific article published on 20 October 2017

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

scientific article published on 13 June 2013

Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia

scientific article

KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia

Leukemia-specific delivery of mutant NOTCH1 targeted therapy.

scientific article published on 20 November 2017

Literature Lab: a method of automated literature interrogation to infer biology from microarray analysis

scientific article

Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis

scientific article

MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells

scientific article

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

scientific article published on September 2014

Mutational heterogeneity in cancer and the search for new cancer-associated genes

scientific article

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

scientific article published on 21 January 2021

New Approaches to Target T-ALL.

scientific article

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 30 September 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 11 November 2014

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group

scientific article

Proteomic and genetic approaches identify Syk as an AML target

scientific article

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

scientific article published on 18 September 2020

SYK is a critical regulator of FLT3 in acute myeloid leukemia

scientific article

Scratching the Surface of Immunotherapeutic Targets in Neuroblastoma

scientific article published in September 2017

Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation ⬇️

scientific article published on May 23, 2013

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

scientific article published on 24 March 2020

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

article

Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia

scientific article published on 9 November 2016

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

scientific article published on 3 October 2017

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer

scientific article published on 01 October 2018

Targeted therapy for fusion-driven high-risk acute leukemia

scholarly article by Yana Pikman & Kimberly Stegmaier published 20 September 2018 in Blood

Targeting Csnk1a1 in leukemia

scientific article

Targeting MTHFD2 in acute myeloid leukemia

scientific article published on 20 June 2016

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

scientific article published on 21 February 2013

Targeting NOTCH1 in hematopoietic malignancy

scientific article published on January 1, 2011

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on April 2016

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

scientific article

The genomic landscape of juvenile myelomonocytic leukemia

scientific article

The genomic landscape of pediatric Ewing sarcoma

scientific article

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia ⬇️

scientific article published on February 13, 2012

Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells

scientific article published on 30 April 2019

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

scientific article

VRK1 as a synthetic lethal target in VRK2-methylated cancers of the nervous system

scientific article published in 2022

List of works by Kimberly Stegmaier

A first-generation pediatric cancer dependency map

A method for high-throughput gene expression signature analysis

A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regu

Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer

Contributors

Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML

EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.

Erratum: Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia

Evaluation of Improved Glycogen Synthase Kinase-3α Inhibitors in Models of Acute Myeloid Leukemia

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

Gefitinib induces myeloid differentiation of acute myeloid leukemia

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Genomic approaches in acute leukemia

High-throughput gene expression profiling of memory differentiation in primary human T cells

High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia

Identification of AML1-ETO modulators by chemical genomics

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia

KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia

Leukemia-specific delivery of mutant NOTCH1 targeted therapy.

Literature Lab: a method of automated literature interrogation to infer biology from microarray analysis

Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis

MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

New Approaches to Target T-ALL.

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group

Proteomic and genetic approaches identify Syk as an AML target

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

SYK is a critical regulator of FLT3 in acute myeloid leukemia

Scratching the Surface of Immunotherapeutic Targets in Neuroblastoma

Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation ⬇️

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer

Targeted therapy for fusion-driven high-risk acute leukemia

Targeting Csnk1a1 in leukemia

Targeting MTHFD2 in acute myeloid leukemia

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

Targeting NOTCH1 in hematopoietic malignancy

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

The genomic landscape of juvenile myelomonocytic leukemia

The genomic landscape of pediatric Ewing sarcoma

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia ⬇️

Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

VRK1 as a synthetic lethal target in VRK2-methylated cancers of the nervous system