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List of works by Pei-Yong Shi

2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase

scientific article

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

scientific journal article

A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening

scientific article

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities

scientific article

A Cyclic Phosphoramidate Prodrug of 2'-deoxy-2'-fluoro-2'-C-methylguanosine for the Treatment of Dengue Infection

scientific article published on 21 September 2020

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

scientific article

A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis

scientific article (publication date: 2017)

A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

scientific article (publication date: March 2017)

A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

article

A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission

scientific article published on 03 August 2020

A Zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity

scientific article published in 2022

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

scientific article published in Nature Communications

A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

scientific article (publication date: February 2017)

A chimeric dengue virus vaccine using Japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates

scientific article published on 09 October 2013

A cocrystal structure of dengue capsid protein in complex of inhibitor

scientific article published on 15 July 2020

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

scientific article

A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-dependent RNA polymerase

scientific article

A genetically stable Zika virus vaccine candidate protects mice against virus infection and vertical transmission

scientific article

A high-throughput assay using dengue-1 virus-like particles for drug discovery

scientific article

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

scientific article published on 22 May 2020

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

scientific article published on 13 August 2020

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

scientific article (publication date: 10 April 2017)

A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine

scientific article published on 07 June 2022

A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis

scientific article

A multidimensional platform for the purification of non-coding RNA species

scientific article published on August 2013

A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host

scientific article

A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

scientific article published on 23 June 2020

A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

scientific article published on 15 October 2020

A novel reporter system for neutralizing and enhancing antibody assay against dengue virus ⬇️

scientific article

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

scientific article published on 18 January 2022

A positively selected mutation in the WNV 2K peptide confers resistance to superinfection exclusion in vivo

scientific article published on 5 August 2014

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

A replication-defective Japanese encephalitis virus (JEV) vaccine candidate with NS1 deletion confers dual protection against JEV and West Nile virus in mice

scientific article published on 05 August 2020

A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis

scientific article

A single amino acid substitution in the core protein of West Nile virus increases resistance to acidotropic compounds

scientific article (publication date: 2013)

A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19

scientific article published in 2021

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. ⬇️

scientific article

A single residue in the αB helix of the E protein is critical for Zika virus thermostability

scientific article published on 24 January 2018

A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

scientific article

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

scientific article published on 22 September 2017

A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

scientific article published on 07 September 2018

A small molecule fusion inhibitor of dengue virus

scientific article

A survey of core replacements in indole-based HIV-1 attachment inhibitors

scientific article published on 28 March 2019

A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence

scientific article

A translation inhibitor that suppresses dengue virus in vitro and in vivo

scientific article

A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants

scientific article published on 17 August 2021

Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir

scientific article

Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus

scientific article

Adulthood Sequelae of Congenital Zika Virus Infection in Mice

scientific article

Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments

scholarly article by Senyan Du et al published 22 March 2019 in Nature Communications

An Infectious cDNA Clone of SARS-CoV-2

scientific article published on 09 April 2020

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

scientific article

An Integrated Research–Clinical BSL-2 Platform for a Live SARS-CoV-2 Neutralization Assay

scientific article published on 31 August 2023

An adenosine nucleoside inhibitor of dengue virus

scientific article

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

scientific article published on 28 November 2019

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

scientific article published on 29 January 2018

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

scientific article

Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2

scientific article published on 01 December 2020

Anti-Zika virus RNAi in neural progenitor cells

scientific article published on 01 April 2019

Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives

scientific article published on 26 February 2014

Anti-infectives: can cellular screening deliver?

scientific article

Antiviral effect of interferon lambda against West Nile virus

scientific article (publication date: July 2009)

Attenuated activation of pulmonary immune cells in mRNA-1273–vaccinated hamsters after SARS-CoV-2 infection

scientific article published in 2021

Author Correction: Antiviral agents: Targeting vesicle size

scientific article published on 01 December 2018

Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells

scholarly article by Daniel P Strange et al published 16 July 2019 in mBio

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

scientific article published in 2021

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

scientific article published on 27 May 2021

BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants

scientific article

Biochemical and genetic characterization of dengue virus methyltransferase

scientific article

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

scientific article

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential

scientific article published on 10 March 2020

CCR2 Signaling Restricts SARS-CoV-2 Infection

scholarly article by Abigail Vanderheiden published in November 2021

CMPK2 restricts Zika virus replication by inhibiting viral translation

scientific article published in 2023

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T-cell responses

scientific article published on 30 September 2020

Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

scientific article (publication date: October 2016)

Characterization of a candidate tetravalent vaccine based on 2'-O-methyltransferase mutants

scientific article published on 3 January 2018

Characterization of dengue virus NS4A and NS4B protein interaction

scientific article

Characterization of dengue virus resistance to brequinar in cell culture

scientific article

Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings

scientific article

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

scientific article

Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

scientific article

Concurrent human antibody and TH1 type T-cell responses elicited by a COVID-19 RNA vaccine

preprint

Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

scientific article

Construction and characterization of subgenomic replicons of New York strain of West Nile virus

scientific article published on May 2002

Construction of Stable Reporter Flaviviruses and Their Applications

scientific article published on 25 September 2020

Correction: Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques.

scientific article published on 10 September 2013

Correction: Role of microglia in the dissemination of Zika virus from mother to fetal brain

scientific article

Correction: Zika virus has oncolytic activity against glioblastoma stem cells

scientific article published on 15 September 2017

Crystal Structure of Enterovirus 71 RNA-Dependent RNA Polymerase Complexed with Its Protein Primer VPg: Implication for a trans Mechanism of VPg Uridylylation ⬇️

scientific article published on March 13, 2013

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

scientific article

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

scientific article

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein

scientific article (publication date: August 2009)

Defining the risk of SARS-CoV-2 variants on immune protection

scientific article published on 31 March 2022

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

scientific article published on 5 September 2021

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

scientific article published in May 2022

Dengue NS2A Protein Orchestrates Virus Assembly

scientific article published on 17 October 2019

Dengue and Zika RNA-RNA Interactomes Reveal Virus Permissive and Restrictive Factors in Human Cells

scientific article published in 2021

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

scientific article published on 28 July 2017

Dengue therapeutics, chemoprophylaxis, and allied tools: state of the art and future directions

scientific article (publication date: August 2014)

Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection

scientific article published on 23 August 2019

Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

scientific article published on 30 March 2020

Detection and quantification of flavivirus NS5 methyl-transferase activities

scientific article published on January 2013

Detection of antibodies to West Nile virus in equine sera using microsphere immunoassay.

scientific article

Determinants of Dengue Virus NS4A Protein Oligomerization

scientific article published on April 2015

Development and characterization of a stable eGFP enterovirus 71 for antiviral screening ⬇️

scientific article published on December 22, 2012

Development and characterization of a stable luciferase dengue virus for high-throughput screening

scientific article published on 7 May 2011

Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells

scientific article published on 18 October 2013

Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies

scientific article published on 01 December 2020

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

scientific article published on 14 February 2018

Development of a stable Gaussia luciferase enterovirus 71 reporter virus

scientific article published on 2 April 2015

Did Zika Virus Mutate to Cause Severe Outbreaks?

scientific article published on 11 June 2018

Difficulties and advancements in developing drugs for the treatment of dengue fever

scientific article published on 12 November 2013

Dimerization of flavivirus NS4B protein

scientific article published on 03 January 2014

Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions

scientific article

Discovery of Dengue Virus NS4B Inhibitors

scientific article published on 27 May 2015

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

scientific article

Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design

Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events

scientific article

Drug discovery for the developing world: progress at the Novartis Institute for Tropical Diseases.

scientific article

Drug repurposing approach to combating coronavirus: Potential drugs and drug targets

scientific article published on 05 December 2020

Dysregulation of Ephrin Receptor and PPAR signaling pathways in Neural Progenitor Cells Infected by Zika Virus

scientific article published on 01 September 2020

EXTH-22. TARGETING A NEWLY DISCOVERED IMMUNE CHECKPOINT, SIGLEC-15, INCREASES ONCOLYTIC EFFICACY OF ZIKA VIRUS (ZIKV) IN GLIOBLASTOMA (GBM)

scientific article published in 2022

Engineering SARS-CoV-2 using a reverse genetic system

scientific article published on 29 January 2021

Enterovirus 71 VPg Uridylation Uses a Two-Molecular Mechanism of 3D Polymerase ⬇️

scientific article published on October 10, 2012

Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

scientific article published on 08 July 2020

Erratum for Chen et al., "Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate"

scientific article published on 02 April 2019

Evaluation of a Novel Reporter Virus Neutralization Test for the Serological Diagnosis of Zika and Dengue Virus Infection

scientific article published on 02 August 2017

Evasion of Type I Interferon by SARS-CoV-2

scientific article published on 19 September 2020

Evasion of early innate immune response by 2'-O-methylation of dengue genomic RNA.

scientific article published on 04 October 2016

Evidence for the Existence of a Pseudoknot Structure at the 3‘ Terminus of the Flavivirus Genomic RNA †

scientific article

Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

scientific article

Exclusion of West Nile Virus Superinfection through RNA Replication

scientific article (publication date: November 2009)

Flavivirus Entry Inhibitors

scientific article published on 23 July 2015

Flavivirus NS4B protein: Structure, function, and antiviral discovery

scientific article published in November 2022

Flavivirus NS5 Prevents the InSTATement of IFN.

scientific article published on September 2014

Flavivirus RNA cap methyltransferase: structure, function, and inhibition ⬇️

scientific article published on August 1, 2010

Flavivirus RNA methylation

scientific article published on 31 January 2014

Flavivirus methyltransferase: a novel antiviral target

scientific article published on 05 June 2008

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

scientific article

Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

scholarly article by Ruben Soto-Acosta et al published 4 December 2018 in eLife

Functional Analysis of Glycosylation of Zika Virus Envelope Protein

scientific article published in October 2017

Functional Analysis of Mosquito-Borne Flavivirus Conserved Sequence Elements within 3' Untranslated Region of West Nile Virus by Use of a Reporting Replicon That Differentiates between Viral Translation and RNA Replication

scientific article (publication date: September 2003)

Functional analysis of two cavities in flavivirus NS5 polymerase

scientific article

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

scientific article published on 26 August 2020

Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening

scientific article published on 12 February 2017

Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus

scientific article

Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay

scientific article published on 25 September 2015

Genetic Interactions among the West Nile Virus Methyltransferase, the RNA-Dependent RNA Polymerase, and the 5' Stem-Loop of Genomic RNA

scientific article

Genetic analysis of West Nile virus containing a complete 3′CSI RNA deletion ⬇️

scientific article published on October 20, 2010

Genetic and biochemical characterizations of Zika virus NS2A protein

scholarly article published by Jing Zou in 2019

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

scientific article published on 21 September 2021

Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching

scientific article

Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus

scientific article published on 9 January 2015

Genetic stability of live-attenuated Zika vaccine candidates

scientific article published on 04 September 2019

Genetic systems of West Nile virus and their potential applications

scientific article published on August 1, 2003

Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia

scientific article published on 14 March 2015

Glucosidase inhibitors suppress SARS-CoV-2 in tissue culture and may potentiate

scientific article

High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

scholarly article published 23 March 2018

High-throughput assays using a luciferase-expressing replicon, virus-like particles, and full-length virus for West Nile virus drug discovery

scientific article

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus

scientific article published on 29 March 2010

Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, precursor membrane (prM) protein cleavage, and entry

scientific article

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

scientific article published on 7 March 2018

IMMU-43. ZIKA VIRUS TO TREAT GLIOMA: TURNING COLD TUMORS HOT

scientific article published in 2020

IMMU-47. HARNESSING ZIKA VIRUS (ZIKV) ONCOLYTIC ACTIVITY IN BRAIN TUMORS

scholarly article by Arijita Jash et al published 5 November 2018 in Neuro-Oncology

Identification and characterization of inhibitors of West Nile virus

scientific article

Identification of compounds with anti-West Nile Virus activity

scientific article published in March 2006

Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections

scientific article

Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign

scientific article

Identifying optimal capsid duplication length for the stability of reporter flaviviruses

scientific article published on 28 September 2020

Immunoassay Targeting Nonstructural Protein 5 To Differentiate West Nile Virus Infection from Dengue and St. Louis Encephalitis Virus Infections and from Flavivirus Vaccination

scientific article (publication date: September 2003)

In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus

scientific article

In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age

scientific article published on 22 June 2020

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

scientific article published on 08 September 2020

Incidence and effects of West Nile virus infection in vaccinated and unvaccinated horses in California.

scientific article published on January 2007

Infection Kinetics and Transmissibility of a Reanimated Dengue Virus Serotype 4 Identified Originally in Wild Aedes aegypti From Florida

scientific article published in 2021

Infection and mRNA-1273 vaccine antibodies neutralize SARS-CoV-2 UK variant

scientific article

Infectious cDNA clone of the epidemic west nile virus from New York City

scientific article

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis ⬇️

scientific article published on April 20, 2011

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single molecule perspective

scientific article

Inhibition of dengue virus RNA synthesis by an adenosine nucleoside

scientific article

Inhibition of dengue virus by an ester prodrug of an adenosine analog

scientific article

Inhibition of dengue virus by targeting viral NS4B protein ⬇️

scientific article published on August 24, 2011

Inhibition of dengue virus polymerase by blocking of the RNA tunnel

scientific article

Inhibition of enterovirus 71 by adenosine analog NITD008

scientific article

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

scientific article

Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells

scientific article

Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins

scientific article (publication date: February 2005)

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns

scientific article

Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity

scientific article

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives

scientific article

Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents ⬇️

scientific article published on November 6, 2012

Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors ⬇️

scientific article published on November 5, 2012

Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity

scientific article published on 01 January 2019

Interaction between the Cellular Protein eEF1A and the 3'-Terminal Stem-Loop of West Nile Virus Genomic RNA Facilitates Viral Minus-Strand RNA Synthesis

scientific article

Internally deleted WNV genomes isolated from exotic birds in New Mexico: Function in cells, mosquitoes, and mice ⬇️

scientific article published on February 23, 2012

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

scientific article

JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis

scientific article published on 18 January 2022

K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B.

scientific article published on 30 December 2017

Keratinocytes Are Cell Targets of West Nile Virus In Vivo ⬇️

scientific article published on March 2, 2011

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

scientific article published on 17 August 2021

Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors

scientific article published on 2 February 2015

Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation ⬇️

scientific article published on October 26, 2011

Live attenuated vaccine: the first clinically approved dengue vaccine?

scientific article published on 18 December 2013

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

scientific article published on 25 January 2021

Mapping the Interactions between the NS4B and NS3 proteins of dengue virus

scientific article published on 14 January 2015

Maternal vaccination and protective immunity against Zika virus vertical transmission

scientific article published on 12 December 2019

Membrane Topology and Function of Dengue Virus NS2A Protein

scientific article

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580.

scientific article published on 14 August 2014

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

scientific article

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

scientific article published on 19 September 2019

Molecular detection of West Nile virus RNA.

scientific article

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

scientific article

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

scientific article

Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

scientific article published on 04 November 2021

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

scientific article published on December 2009

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

scientific article published on 3 February 2021

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

scientific article published on 19 March 2013

NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues

scientific article published on 12 December 2019

NS5 of dengue virus mediates STAT2 binding and degradation

scientific article

Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants

scientific article published on 03 June 2021

Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera

scientific article

Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

scientific article

Neutralizing Activity of BNT162b2-Elicited Serum

scientific article

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

scientific article

Nitazoxanide and JIB-04 have broad-spectrum antiviral activity and inhibit SARS-CoV-2 replication in cell culture and coronavirus pathogenesis in a pig model

scientific article published on 25 September 2020

Nonconsensus West Nile Virus Genomes Arising during Mosquito Infection Suppress Pathogenesis and Modulate Virus Fitness In Vivo ⬇️

scientific article published on September 21, 2011

Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice

scientific article published on 7 March 2013

Novel non-segmented negative-sense RNA virus-based vaccine platforms for Zika virus

scientific article published in 2020

Nucleic acid-based inhibition of flavivirus infections

scientific article published on January 2008

Oral Supplementation with AHCC, a Standardized Extract of Cultured Mycelia, Enhances Host Resistance against SARS-CoV-2 Infection

Overlapping and distinct molecular determinants dictating the antiviral activities of TRIM56 against flaviviruses and coronavirus

scientific article published on 24 September 2014

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Peli1 signaling blockade attenuates congenital zika syndrome

scientific article published on 16 June 2020

Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report

preprint

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

scientific article published on 12 August 2020

Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo

scientific article published on 23 February 2012

Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development

scientific article published on 19 February 2014

Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes

scientific article

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

scientific article

Potential High-Throughput Assay for Screening Inhibitors of West Nile Virus Replication

scientific article

Potential Mechanisms for Enhanced Zika Epidemic and Disease

scientific article published on 22 January 2018

Publisher Correction: COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

correction of a scholarly article

Publisher Correction: Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

correction of a scholarly article

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

scientific article published on 01 November 2019

Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C)

scientific article published on 02 September 2020

RNA structures required for production of subgenomic flavivirus RNA

scientific article (publication date: November 2010)

RNA-Based COVID-19 Vaccine BNT162b2 Selected for a Pivotal Efficacy Study

scientific article published on 20 August 2020

RPLP1 and RPLP2 Are Essential Flavivirus Host Factors That Promote Early Viral Protein Accumulation

scientific article (publication date: 15 February 2017)

Rational Design of a Flavivirus Vaccine by Abolishing Viral RNA 2′- O Methylation ⬇️

scientific article published on March 13, 2013

Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques

scientific article

Recent advances in flavivirus antiviral drug discovery and vaccine development

scientific article published on January 2006

Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A.

scientific article published on 20 December 2013

Replication-Defective West Nile Virus with NS1 Deletion as a New Vaccine Platform for Flavivirus

scientific article published on 13 August 2019

Report of the fifth symposium on emerging viral diseases ⬇️

scientific article published on March 22, 2013

Reporter Virus Neutralization Test Evaluation for Dengue and Zika Virus Diagnosis in Flavivirus Endemic Area

scientific article published on 05 July 2021

Repurposing an HIV Drug for Zika Virus Therapy

scientific article published on 14 October 2019

Reserve genetic approaches for the development of Zika vaccines and therapeutics

scientific article published on 18 June 2020

Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1.

scientific article

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

scientific article

Restriction of Zika Virus by Host Innate Immunity

scientific article

Reverse Genetics of Zika Virus

scientific article

Role of microglia in the dissemination of Zika virus from mother to fetal brain

scientific article published on 06 July 2020

Role of mutational reversions and fitness restoration in Zika virus spread to the Americas

scientific article

Role of the mutant spectrum in adaptation and replication of West Nile virus

scientific article published on March 2007

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

scientific article published on 05 November 2020

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

scientific article

SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3

scientific article published in 2021

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

scientific article published on 14 October 2020

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

scientific article published on 24 August 2016

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

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Separate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2′-O methylations of viral RNA cap

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Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production

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Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

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Small Molecules and Antibodies for Zika Therapy

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Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

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Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

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Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase

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Strategies for the identification of inhibitors of West Nile virus and other flaviviruses.

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Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD

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Structure and Function of Flavivirus NS5 Methyltransferase

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Structure and function of the 3' terminal six nucleotides of the west nile virus genome in viral replication

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Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

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Susceptibility to SARS-CoV-2 of Cell Lines and Substrates Commonly Used to Diagnose and Isolate Influenza and Other Viruses

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Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors

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Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

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Targeting dengue virus NS4B protein for drug discovery

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Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy

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Targeting vesicle size

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Ten years of dengue drug discovery: progress and prospects

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Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

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Testing Antiviral Compounds in a Dengue Mouse Model ⬇️

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Tetracycline-inducible packaging cell line for production of flavivirus replicon particles

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The 5′ and 3′ Downstream AUG Region Elements Are Required for Mosquito-Borne Flavivirus RNA Replication ⬇️

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The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry

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The Emerging Duck Flavivirus Is Not Pathogenic for Primates and Is Highly Sensitive to Mammalian Interferon Antiviral Signaling

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The N501Y spike substitution enhances SARS-CoV-2 infection and transmission

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The West Nile virus mutant spectrum is host-dependant and a determinant of mortality in mice

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The challenges of dengue drug discovery and development

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The dengue virus NS5 protein as a target for drug discovery

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The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization

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The flavivirus-conserved penta-nucleotide in the 3' stem-loop of the West Nile virus genome requires a specific sequence and structure for RNA synthesis, but not for viral translation

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The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry

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The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway

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The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication

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The role of sequence context, nucleotide pool balance and stress in 2'-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA.

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The search for nucleoside/nucleotide analog inhibitors of dengue virus

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The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation

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The structural basis for serotype-specific neutralization of dengue virus by a human antibody

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Therapeutic Potential of Spirooxindoles as Antiviral Agents

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Therapeutics for Neglected Infectious Diseases: Progress and Challenge

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Therapeutics for dengue: recommendations for design and conduct of early-phase clinical trials

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Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses

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Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses

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Transmembrane Domains of NS2B Contribute to both Viral RNA Replication and Particle Formation in Japanese Encephalitis Virus

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Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate

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Triaryl pyrazoline compound inhibits flavivirus RNA replication

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Two RNA tunnel inhibitors bind in highly conserved sites in Dengue virus NS5 polymerase: structural and functional studies

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Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly

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Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

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Type I interferon signals in macrophages and dendritic cells control dengue virus infection: implications for a new mouse model to test dengue vaccines

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U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication ⬇️

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Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response

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Understanding Zika Virus Stability and Developing a Chimeric Vaccine through Functional Analysis

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Use of the immunoglobulin G avidity assay to differentiate between recent Zika and past dengue virus infections

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Using Next Generation Sequencing to Study the Genetic Diversity of Candidate Live Attenuated Zika Vaccines

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Using a virion assembly-defective dengue virus as a vaccine approach

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Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery

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Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

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Vesicular stomatitis virus and DNA vaccines expressing Zika virus nonstructural protein 1 (NS1) induce substantial but not sterilizing protection against Zika virus infection

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Viral pathogenesis in mice is similar for West Nile virus derived from mosquito and mammalian cells

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West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

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West Nile Virus Experimental Evolution in vivo and the Trade-off Hypothesis ⬇️

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West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

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West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.

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West Nile virus

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West Nile virus drug discovery

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West Nile virus envelope protein glycosylation is required for efficient viral transmission by Culex vectors

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West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions

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West Nile virus infection of Drosophila melanogaster induces a protective RNAi response

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West Nile virus infection of the placenta

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Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage

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Zika Virus Infection Alters Gene Expression and Poly-Adenylation Patterns in Placental Cells

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Zika Virus Infects Human Sertoli Cells and Modulates the Integrity of the In Vitro Blood-Testis Barrier Model ⬇️

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Zika Virus NS2A-Mediated Virion Assembly

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Zika Virus Replicons for Drug Discovery

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Zika Virus Vaccine: Progress and Challenges

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Zika Virus: Diagnosis, Therapeutics, and Vaccine

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Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

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Zika structural genes determine the virulence of African and Asian lineages

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Zika virus epidemic in Brazil. I. Fatal disease in adults: clinical and laboratorial aspects

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Zika virus evolution in the presence of dengue virus-elicited cross-reactive immunity

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Zika virus has oncolytic activity against glioblastoma stem cells

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Zika virus induces neuronal and vascular degeneration in developing mouse retina

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Zika virus infection elicits auto-antibodies to C1q.

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Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade

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Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease

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Zika virus: History, emergence, biology, and prospects for control

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Zika virus: a new threat from mosquitoes

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