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List of works by Ryan F.L. O'Shaughnessy

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic d

scientific article published on 29 November 2016

A novel microdeletion in LOR causing autosomal dominant loricrin keratoderma.

scientific article

AKT1 loss correlates with episomal HPV16 in vulval intraepithelial neoplasia.

scientific article

AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation.

scientific article

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.

scientific article published on 17 September 2009

Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation

scientific article published on 18 January 2021

Analysis of Gene Expression Using High-Density and IFN-γ-Specific Low-Density cDNA Arrays

article

CD161+ Tconv and CD161+ Treg Share a Transcriptional and Functional Phenotype despite Limited Overlap in TCRβ Repertoire

scientific article published on 06 March 2017

Constitutive Autophagy and Nucleophagy during Epidermal Differentiation.

scientific article

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

scholarly article by I. I. Badshah et al published 26 October 2018 in British Journal of Dermatology

Identifying a Hyperkeratosis Signature in Autosomal Recessive Congenital Ichthyosis: Mdm2 Inhibition Prevents Hyperkeratosis in a Rat ARCI Model

article

Inherited disorders of the skin in human and mouse: from development to differentiation.

scientific article published in January 2004

Insight from the Air–Skin Interface

scientific article published on 01 February 2015

Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis

scientific journal article

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis. ⬇️

scientific article published on 14 January 2016

Orchestrated control of filaggrin-actin scaffolds underpins cornification.

scientific article published on 15 March 2018

PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation

scientific article (publication date: 8 December 2000)

Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity.

scientific article published on 23 February 2017

Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas.

scientific article published on 11 July 2017

Protein kinases involved in epidermal barrier formation: The AKT family and other animals

scientific article published on 01 August 2018

Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition

scientific article

Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation

scientific article published on 02 July 2019

Stem cells in the epidermis.

scientific article

T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss

scientific article

Tape Strips in Dermatology Research

scientific article published on 28 December 2020

Targeting tryptophan transport and breakdown in basal cell carcinoma

scientific article published on 01 January 2019

The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling.

scientific article published on October 2004

The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene

scientific journal article

The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling.

scientific article published on 13 August 2012

The protein phosphatase 2A regulatory subunit Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition

scientific article

The role of BMP signalling in the control of ID3 expression in the hair follicle

scientific article published on 01 October 2004

Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues

scientific article

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