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List of works by Francois Ghiringhelli

AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.

scientific article published on July 2015

Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX-Bevacizumab Drug Treatment Regimen.

scientific article published on 5 August 2016

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors

scientific article (publication date: October 2009)

Adaptive pulse shape control in a diode-seeded nanosecond fiber MOPA system.

scientific article

Allelic loss of 9p21.3 is a prognostic factor in 1p/19q codeleted anaplastic gliomas

scientific article

Antibiotic Use Does Not Appear to Influence Response to Nivolumab

scientific article published on June 2017

Artificial intelligence-guided tissue analysis combined with immune infiltrate assessment predicts stage III colon cancer outcomes in PETACC08 study

scientific article published on 28 November 2019

Association of 5-FU Therapeutic Drug Monitoring to DPD Phenotype Assessment May Reduce 5-FU Under-Exposure

scientific article published on 23 November 2020

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

scientific article (publication date: 16 December 2011)

Baseline Splenic Volume as a Prognostic Biomarker of FOLFIRI Efficacy and a Surrogate Marker of MDSC Accumulation in Metastatic Colorectal Carcinoma

scientific article published on 31 May 2020

Baseline splenic volume as a surrogate marker of FOLFIRINOX efficacy in advanced pancreatic carcinoma.

scientific article published on 22 May 2018

Bevacizumab Maintenance Versus No Maintenance During Chemotherapy-Free Intervals in Metastatic Colorectal Cancer: A Randomized Phase III Trial (PRODIGE 9).

scientific article published on 18 January 2018

Cancer is not just a disease of a tissue: It is a host disease

scientific article published on 16 April 2008

Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells

scientific article published on 16 March 2012

Chemoimmunotherapy of Tumors: Cyclophosphamide Synergizes with Exosome Based Vaccines

scientific article published on 01 March 2006

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

scientific article published on 25 May 2020

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

Correction: Corrigendum: The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

scientific article published in December 2015

Correction: Novel chemical probes for the investigation of nonribosomal peptide assembly.

scientific article

Correction: Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway

scientific article published on 20 April 2017

Correction: SNP Array Analysis Reveals Novel Genomic Abnormalities Including Copy Neutral Loss of Heterozygosity in Anaplastic Oligodendrogliomas.

scientific article published on 8 May 2013

Dacarbazine mediate antimelanoma effects via NK cells.

scientific article

Dynamic evaluation of circulating tumour cells in patients with advanced gastric and oesogastric junction adenocarcinoma: Prognostic value and early assessment of therapeutic effects

scientific article published on 26 April 2017

EGFR amplification induces sensitivity to antiEGFR therapy in pancreatic acinar cell carcinoma.

scientific article

Effect of obesity on disease-free and overall survival in node-positive breast cancer patients in a large French population: a pooled analysis of two randomised trials.

scientific article

Effects of polyphenols and lipids from Pennisetum glaucum grains on T-cell activation: modulation of Ca(2+) and ERK1/ERK2 signaling.

scientific article published in December 2015

Efficiency of olaparib in colorectal cancer patients with an alteration of the homologous repair protein

scientific article published on December 2016

Epidemiology and prognosis of synchronous and metachronous colon cancer metastases: a French population-based study

scientific article published on 5 June 2014

FOLFIRI+bevacizumab induction chemotherapy followed by bevacizumab or observation in metastatic colorectal cancer, a phase III trial (PRODIGE 9 – FFCD 0802)

scientific article published on 20 January 2015

FOLFIRINOX bevacizumab is a promising therapy for chemorefractory metastatic colorectal cancer

scientific article published on 08 July 2014

Feasibility and safety of weekly sequential epirubicin-paclitaxel as adjuvant treatment for operable breast cancer patients older than 70 years.

scientific article

Fluorouracil, leucovorin and irinotecan associated with aflibercept can induce microscopic colitis in metastatic colorectal cancer patients.

scientific article

Freshly isolated bone marrow cells induce death of various carcinoma cell lines

article

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

scientific article published on 2 November 2017

Harnessing the intestinal microbiome for optimal therapeutic immunomodulation

scientific article

Heat Shock Protein 70 Neutralization Exerts Potent Antitumor Effects in Animal Models of Colon Cancer and Melanoma

article

Hepatic arterial chemotherapy with raltitrexed and oxaliplatin versus standard chemotherapy in unresectable liver metastases from colorectal cancer after conventional chemotherapy failure (HEARTO): a randomized phase-II study

scientific article published on 04 July 2019

High pressure does not counterbalance the advantages of open techniques over closed techniques during heated intraperitoneal chemotherapy with oxaliplatin

scientific article published on 12 July 2014

Hypotonic stress enhances colon cancer cell death induced by platinum derivatives and immunologically improves antitumor efficacy of intraperitoneal chemotherapy

scientific article published on 28 August 2019

IRF8-dependent molecular complexes control the Th9 transcriptional program.

scientific article published on 12 December 2017

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

scientific article published on 01 December 2020

Imidazo[2,1-b]benzothiazol Derivatives as Potential Allosteric Inhibitors of the Glucocorticoid Receptor.

scientific article published on 26 February 2018

Immunodynamics of explanted human tumors for immuno-oncology

scientific article published on 29 December 2020

Immunogenic Cell Death and Elimination of Immunosuppressive Cells: A Double-Edged Sword of Chemotherapy

scientific article published on 16 September 2020

Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells.

scientific article published on March 2007

Immunomodulation and anti-inflammatory roles of polyphenols as anticancer agents.

scientific article published on October 2012

Importance of lipid microdomains, rafts, in absorption, delivery, and biological effects of resveratrol.

scientific article published on July 2013

Improvement in survival of metastatic colorectal cancer: are the benefits of clinical trials reproduced in population-based studies?

scientific article published on 30 April 2013

In situ immune response after neoadjuvant chemotherapy for breast cancer predicts survival

scientific article published on 25 March 2011

Influcence of localization of primary tumor on effectiveness of 5-fluorouracil/leucovorin combined with irinotecan and oxaliplatin (FOLFIRINOX) in patients with metastatic pancreatic adenocarcinoma: a retrospective study

scientific article published on 01 September 2012

Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFα.

scientific article published on 8 February 2016

Interleukin-1β and Cancer

scientific article published on 04 July 2020

Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment

scientific article published on 07 May 2021

La calréticuline détermine l’immunogénicité de la chimiothérapie et de la radiothérapie antitumorales

scientific article published in March 2007

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance.

scientific article published on 22 January 2018

MER4 endogenous retrovirus correlated with better efficacy of anti-PD1/PD-L1 therapy in non-small cell lung cancer

scientific article published on 01 March 2022

Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

scientific article published on 08 September 2006

Metronomic cyclophosphamide with cisplatin and bevacizumab: a new chemotherapeutic regimen for refractory anaplastic ependymoma.

scientific article

Metronomic oral cyclophosphamide prednisolone chemotherapy is an effective treatment for metastatic hormone-refractory prostate cancer after docetaxel failure.

scientific article published on October 2010

Molecular characteristics of immunogenic cancer cell death.

scientific article

Next-generation sequencing analysis of lung and colon carcinomas reveals a variety of genetic alterations.

scientific article

Novel chemical probes for the investigation of nonribosomal peptide assembly.

scientific article

Obesity As a Risk Factor for Anthracyclines and Trastuzumab Cardiotoxicity in Breast Cancer: A Systematic Review and Meta-Analysis.

scientific article

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer ⬇️

scientific article published on 15 March 2018

Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T Cells

scientific article published on 27 March 2008

Phase II multicentre study of efficacy and feasibility of dose-intensified preoperative weekly cisplatin, epirubicin, and paclitaxel (PET) in resectable gastroesophageal cancer

scientific article published on 14 May 2014

Phase Ib/II trial evaluating the safety, tolerability and immunological activity of durvalumab (MEDI4736) (anti-PD-L1) plus tremelimumab (anti-CTLA-4) combined with FOLFOX in patients with metastatic colorectal cancer.

scientific article published on 19 June 2018

Precision medicine in breast cancer: reality or utopia?

scientific article

Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy

scientific article published on 13 March 2010

Prise en charge des cancers solides et des hémopathies malignes du sujet âgé : l'oncogériatrie, une discipline en devenir. Seconde partie : traitement des cancers solides (partie 2) et des hémopathies malignes du sujet âgé

scientific article published on 18 October 2004

Prise en charge des cancers solides et des hémopathies malignes du sujet âgé : l’oncogériatrie une discipline en devenir

scientific article published on 21 December 2004

Prognostic value of angiopoietin-2 for death risk stratification in patients with metastatic colorectal carcinoma

scientific article published on 12 January 2015

Prognostic value of baseline seric Syndecan-1 in initially unresectable metastatic colorectal cancer patients: a simple biological score.

scientific article published on 29 July 2016

Protective effects of polyphenol-rich infusions from carob (Ceratonia siliqua) leaves and cladodes of Opuntia ficus-indica against inflammation associated with diet-induced obesity and DSS-induced colitis in Swiss mice.

scientific article

Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer

scientific article published on 10 September 2020

Randomized phase II trial of irinotecan and bevacizumab as neo-adjuvant and adjuvant to temozolomide-based chemoradiation compared with temozolomide-chemoradiation for unresectable glioblastoma: final results of the TEMAVIR study from ANOCEF†.

scientific article

Relation between bevacizumab dose intensity and high-grade glioma survival: a retrospective study in two large cohorts.

scientific article

Reply to M. Mo et al

scientific article published on 04 June 2018

Response to first line chemotherapy regimen is associated with efficacy of nivolumab in non-small-cell lung cancer

scientific article published on 16 June 2017

Restoration of Antitumor Immunity Through Selective Inhibition of Myeloid Derived Suppressor Cells by Anticancer Therapies ⬇️

scientific article published on July 1, 2011

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer.

scientific article published on 22 November 2015

Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death.

scientific article published on 14 March 2013

Role of pleural and peritoneal metastasis in immune checkpoint inhibitors efficacy patients with non-small cell lung cancer: real-world data from a large cohort in France

scientific article published on 30 May 2020

Socs3 induction by PPARγ restrains cancer-promoting inflammation.

scientific article published on July 2013

Sodium citrate versus saline catheter locks for non-tunneled hemodialysis central venous catheters in critically ill adults: a randomized controlled trial

scientific article published on 29 November 2011

Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression

scientific article published on 08 March 2012

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome.

scientific article published on 11 September 2015

TH9 cells in anti-tumor immunity

scientific article

Th9 cells: a novel CD4 T-cell subset in the immune war against cancer.

scientific article

The anti-tumor immune response in breast cancer: Update and therapeutic perspectives

scientific article published on 31 January 2017

The role of telomeres in predicting individual radiosensitivity of patients with cancer in the era of personalized radiotherapy

scientific article

The transfer of multigene panel testing for hereditary breast and ovarian cancer to healthcare: What are the implications for the management of patients and families?

scientific article published on 15 October 2016

Three Versus 6 Months of Oxaliplatin-Based Adjuvant Chemotherapy for Patients With Stage III Colon Cancer: Disease-Free Survival Results From a Randomized, Open-Label, International Duration Evaluation of Adjuvant (IDEA) France, Phase III Trial

scientific article published on 05 April 2018

Transcription Factor Binding Studies in CD4+ T Cells: siRNA Transfection, Chromatin Immunoprecipitation, and Liquid Luminescent DNA Precipitation Assay

scientific article published on January 2017

Tumor Infiltrating Lymphocytes Signature as a New Pan-Cancer Predictive Biomarker of Anti PD-1/PD-L1 Efficacy

scientific article published on 26 August 2020

Tumor destruction using electrochemotherapy followed by CpG oligodeoxynucleotide injection induces distant tumor responses

scientific article published on 08 February 2008

Tumor exosome-mediated MDSC activation.

scientific article published on March 2011

Tumor lymphocyte immune response to preoperative radiotherapy in locally advanced rectal cancer: The LYMPHOREC study

scientific article published on 27 November 2017

Tumor-associated neutrophils correlate with poor prognosis in diffuse large B-cell lymphoma patients.

scientific article

UGT1A1 genotype and irinotecan therapy: general review and implementation in routine practice.

scientific article published on 04 May 2015

Understanding Inflammasomes and PD-1/PD-L1 Crosstalk to Improve Cancer Treatment Efficiency

scientific article published on 27 November 2020

Use of dedicated gene panel sequencing using next generation sequencing to improve the personalized care of lung cancer

scientific article published on 26 March 2016

Utility of exome sequencing in routine care for metastatic colorectal cancer

scientific article published on 10 September 2021

Vaccine strategies against melanoma

scientific article published on 01 February 2006

Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer

scientific article published on 15 October 2009

WITHDRAWN: Nouvelles stratégies innovantes en immunothérapie

retracted scientific article published on 26 April 2018

[An IgG4-related pancreatitis mimicking an adenocarcinoma: A case report]

scientific article published on 17 November 2015

[Case-control study evaluating the incidence of hyperhomocysteinemia in cancer patients in an internal medicine department].

scientific article published on 11 May 2007

[Cellular and molecular purification processes based on the use of magnetic micro-and nanobeads]

scientific article published on 01 January 2004

[Immunological aspects of anticancer chemotherapy]

scientific article published on 01 October 2008

[Impact of chemotherapies on immunosuppression and discovery of new therapeutic targets]

scientific article published on 01 June 2014

[Infectious spondylitis of the odontoid process]

scientific article published on 01 August 2002

[Interest of UGT1A1 genotyping within digestive cancers treatment by irinotecan]

scientific article published on 01 June 2014

[Microbeads, nanobeads and cytometry: applications to the analysis and purification of cells and biomolecules]

scientific article published on 01 September 2003

[Myeloid-derived suppressor cells: a key player in cancer]

scientific article published on 01 June 2010

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