List of works - Nils-Göran Larsson

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

scientific article (publication date: March 1998)

The role of mitochondria in aging

scientific article published on March 2013

Mitochondrial transcription factor A regulates mtDNA copy number in mammals

scientific article published on 11 March 2004

DNA replication and transcription in mammalian mitochondria

scientific article published on January 2007

Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA

scientific article

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

scholarly article

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

scientific article

Somatic Mitochondrial DNA Mutations in Mammalian Aging

scientific article published on January 1, 2010

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression

scientific article published in January 1999

Unraveling the biological roles of reactive oxygen species

scientific article published on April 2011

Strong purifying selection in transmission of mammalian mitochondrial DNA

scientific article

Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology

scientific article published on 26 September 2006

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

scientific article published in November 2000

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.

scientific article

Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome

scientific article

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

scientific article

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

scientific article

MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome

scientific article

Increased mitochondrial mass in mitochondrial myopathy mice

scientific article

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

scientific article published on 21 August 2013

Progressive increase of the mutated mitochondrial DNA fraction in Kearns-Sayre syndrome

scientific article published on 01 August 1990

MTERF3 is a negative regulator of mammalian mtDNA transcription

scientific article

Maintenance and Expression of Mammalian Mitochondrial DNA

scientific article published on March 24, 2016

Mammalian Mitochondria and Aging: An Update

scientific article published on 27 October 2016

Mitochondrial DNA mutations in disease and aging

scientific article

Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion

scientific article published on May 1994

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins

scientific article

The role of mitochondrial DNA mutations and free radicals in disease and ageing

scientific article published on March 7, 2013

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

scientific article published on 24 August 2015

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts

scholarly article

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice

scientific article

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

scientific article published on 15 November 2012

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

scientific article

The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells

scientific article

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons

scientific article published on 21 August 2012

Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy

scientific article

Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.

scientific article

Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

scientific article

NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly

scientific article

Making proteins in the powerhouse

scientific article published on 31 July 2014

Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels.

scientific article

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

scientific article

Mammalian transcription factor A is a core component of the mitochondrial transcription machinery

scientific article

Leber's hereditary optic neuropathy and complex I deficiency in muscle

scientific article published in November 1991

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

scientific article published on 7 February 2013

The Enigma of the Respiratory Chain Supercomplex

scientific article published on April 2017

Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice

scientific article published on 15 November 2007

Loss of LRPPRC causes ATP synthase deficiency

scientific article published on 6 January 2014

Segregation and manifestations of the mtDNA tRNA(Lys) A-->G(8344) mutation of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome

scientific article

A family of putative transcription termination factors shared amongst metazoans and plants

scientific article published on October 2005

List of works by Nils-Göran Larsson

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

The role of mitochondria in aging

Mitochondrial transcription factor A regulates mtDNA copy number in mammals

DNA replication and transcription in mammalian mitochondria

Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

Somatic Mitochondrial DNA Mutations in Mammalian Aging

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression

Unraveling the biological roles of reactive oxygen species

Strong purifying selection in transmission of mammalian mitochondrial DNA

Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.

Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome

Increased mitochondrial mass in mitochondrial myopathy mice

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

Progressive increase of the mutated mitochondrial DNA fraction in Kearns-Sayre syndrome

MTERF3 is a negative regulator of mammalian mtDNA transcription

Maintenance and Expression of Mammalian Mitochondrial DNA

Mammalian Mitochondria and Aging: An Update

Mitochondrial DNA mutations in disease and aging

Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins

The role of mitochondrial DNA mutations and free radicals in disease and ageing

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons

Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy

Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.

Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly

Making proteins in the powerhouse

Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels.

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

Mammalian transcription factor A is a core component of the mitochondrial transcription machinery

Leber's hereditary optic neuropathy and complex I deficiency in muscle

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

The Enigma of the Respiratory Chain Supercomplex

Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice

Loss of LRPPRC causes ATP synthase deficiency

Segregation and manifestations of the mtDNA tRNA(Lys) A-->G(8344) mutation of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome

A family of putative transcription termination factors shared amongst metazoans and plants