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List of works by Hans J. Gelderblom

A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment

scientific article published on 31 March 2015

A Genetic Polymorphism in CTLA-4 Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma

scientific article published on 28 February 2018

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

scientific article published on 11 December 2018

A decade of pharmacogenomics research on tyrosine kinase inhibitors in metastatic renal cell cancer: a systematic review

scientific article published on 3 February 2016

A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti-PD-1 antibody, in patients with advanced solid tumors

scientific article published on 01 March 2020

A multidisciplinary approach to giant cell tumors of tendon sheath and synovium--a critical appraisal of literature and treatment proposal

scientific article published on 17 July 2012

A novel method to address the association between received dose intensity and survival outcome: benefits of approaching treatment intensification at a more individualised level in a trial of the European Osteosarcoma Intergroup

scientific article published on 16 March 2019

A phase 1 and randomized controlled phase 2 trial of the safety and efficacy of the combination of gemcitabine and docetaxel with ontuxizumab (MORAb-004) in metastatic soft-tissue sarcomas

scientific article published on 29 April 2019

A phase I study on the combination of neoadjuvant radiotherapy plus pazopanib in patients with locally advanced soft tissue sarcoma of the extremities

scientific article published on 29 April 2015

A phase I, open-label, multicenter study to evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and various degrees of hepatic function

scientific article published on 25 September 2014

A phase I, open-label, multicenter study to evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and varying degrees of renal function

scientific article published on 07 November 2014

A remarkable response to pazopanib, despite recurrent liver toxicity, in a patient with a high grade endometrial stromal sarcoma, a case report.

scientific article published on 22 January 2018

A single digital droplet PCR assay to detect multiple KIT exon 11 mutations in tumor and plasma from patients with gastrointestinal stromal tumors.

scientific article published on 14 February 2018

A validated assay for the simultaneous quantification of six tyrosine kinase inhibitors and two active metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.

scientific article published on 17 August 2013

Abstract LB-295: Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenibvsplacebo in TKI-refractory metastatic GIST

article

Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab

scientific article

Activity and safety of the multi-target tyrosine kinase inhibitor cabozantinib in patients with metastatic gastrointestinal stromal tumour after treatment with imatinib and sunitinib: European Organisation for Research and Treatment of Cancer phase

scientific article published on 26 May 2020

Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma

scientific article

Adjuvant Zoledronic Acid in High-Risk Giant Cell Tumor of Bone: A Multicenter Randomized Phase II Trial

scientific article published on 30 April 2019

Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities

scientific article published on 12 August 2020

Anthracycline, Gemcitabine, and Pazopanib in Epithelioid Sarcoma: A Multi-institutional Case Series

scientific article published on 13 September 2018

Anti-EGFR Antibody Cetuximab Enhances the Cytolytic Activity of Natural Killer Cells toward Osteosarcoma

scientific article published on 16 November 2011

Anti-emetic drugs in oncology: pharmacology and individualization by pharmacogenetics

scientific article

Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors.

scientific article published in August 2010

Antimitotic agents for the treatment of patients with metastatic castrate-resistant prostate cancer ⬇️

scientific article published on May 1, 2013

Are pathological high-risk features in locally advanced rectal cancer a useful selection tool for adjuvant chemotherapy?

scientific article published on 6 December 2017

Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone

article

Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy.

scientific article

Association of Paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer

scientific article published in July 2005

Association of pazopanib-induced toxicities with outcome of patients with advanced soft tissue sarcoma; a retrospective analysis based on the European Organisation for Research and Treatment of Cancer (EORTC) 62043 and 62072 clinical trials

scientific article published on 04 March 2019

Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma.

scientific article

Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma.

scientific article published on 22 September 2009

Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis

scientific article

Bioequivalence of Liposome-Entrapped Paclitaxel Easy-To-Use (LEP-ETU) formulation and paclitaxel in polyethoxylated castor oil: a randomized, two-period crossover study in patients with advanced cancer.

scientific article

Breath tests to phenotype drug disposition in oncology

scientific article

CYP2D6 genotype in relation to hot flashes as tamoxifen side effect in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial

CYP3A5 and ABCB1 polymorphisms as predictors for sunitinib outcome in metastatic renal cell carcinoma.

scientific article

Central venous access related adverse events after trabectedin infusions in soft tissue sarcoma patients; experience and management in a nationwide multi-center study

scientific article published on 31 January 2017

Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone

scientific article published on 01 July 2019

Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand?

scientific article published on 22 June 2011

Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells.

scientific article

Clinical and pharmacogenetic factors associated with irinotecan toxicity

scientific article published on 16 June 2008

Clinical characteristics and treatment outcome in a large multicentre observational cohort of PDGFRA exon 18 mutated gastrointestinal stromal tumour patients

scientific article published on 8 March 2017

Clinical implications of CYP2D6 genotyping in tamoxifen treatment for breast cancer

scientific article published on January 2009

Clinical outcomes of patients with advanced gastrointestinal stromal tumors: safety and efficacy in a worldwide treatment-use trial of sunitinib

scientific article

Clinical pharmacokinetics of tyrosine kinase inhibitors

scientific article

Comparative pharmacokinetics of unbound paclitaxel during 1- and 3-hour infusions

scientific article published in January 2002

Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. ⬇️

scientific article

Comprehensive analysis of published phase I/II clinical trials between 1990-2010 in osteosarcoma and Ewing sarcoma confirms limited outcomes and need for translational investment ⬇️

scientific article published on January 27, 2012

Comprehensive analysis of published studies involving systemic treatment for chondrosarcoma of bone between 2000 and 2013.

scientific article

Concordance of genotype for polymorphisms in DNA isolated from peripheral blood and colorectal cancer tumor samples

scientific article

Concordance of predictive markers for EGFR inhibitors in primary tumors and metastases in colorectal cancer: a review

scientific article published on 08 July 2011

Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer.

scientific article published on 24 April 2010

Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial

scientific article published on 15 January 2016

Crizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumours with and without anaplastic lymphoma kinase gene alterations (European Organisation for Research and Treatment of Cancer 90101 CREATE): a multicentre, single-drug,

scientific article published on 12 April 2018

Current clinical trials for advanced osteosarcoma and soft tissue sarcoma

scientific article published on July 2014

Current concepts in the treatment of giant cell tumour of bone

scientific article published on 22 May 2020

Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone

scientific article

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis

scientific article published on 19 October 2018

Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study.

scientific article

Denosumab treatment of inoperable or locally advanced giant cell tumor of bone - Multicenter analysis outside clinical trial

scientific article published on 31 March 2018

Determination of topotecan in human whole blood and unwashed erythrocytes by high-performance liquid chromatography

scientific article published in January 2002

Development of a pharmacokinetic model of mitotane: toward personalized dosing in adrenocortical carcinoma

scientific article published on 01 February 2015

Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple DPYD Variants

article

Differences in 5-hydroxytryptamine-3B haplotype frequencies between Asians and Caucasians.

scientific article

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

scientific article

Diflomotecan, a promising homocamptothecin for cancer therapy

scientific article published on 01 January 2009

Distribution of paclitaxel in plasma and cerebrospinal fluid

scientific article published in June 2003

Dose and schedule-finding study of oral topotecan and weekly cisplatin in patients with recurrent ovarian cancer ⬇️

scientific article published on October 19, 2001

Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial.

scientific article

Doxorubicin plus dacarbazine, doxorubicin plus ifosfamide, or doxorubicin alone as a first-line treatment for advanced leiomyosarcoma: A propensity score matching analysis from the European Organization for Research and Treatment of Cancer Soft Tiss

scientific article published on 04 March 2020

Dried blood spot analysis for therapeutic drug monitoring of pazopanib

scientific article

Dutch Melanoma Treatment Registry: Quality assurance in the care of patients with metastatic melanoma in the Netherlands.

scientific article published on 25 December 2016

Dynamic prediction of overall survival: a retrospective analysis on 979 patients with Ewing sarcoma from the German registry

scientific article published on 12 October 2020

Early Evaluation of Response Using 18F-FDG PET Influences Management in Gastrointestinal Stromal Tumor Patients Treated with Neoadjuvant Imatinib

scientific article published on 28 September 2017

Early cessation of the clinical development of LiPlaCis, a liposomal cisplatin formulation.

scientific article

Effect of ABCG2 genotype on the oral bioavailability of topotecan

scientific article published on 11 June 2005

Effect of cigarette smoking on imatinib in patients in the soft tissue and bone sarcoma group of the EORTC.

scientific article

Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer.

scientific article published on 12 April 2010

Effect of gastrointestinal resection on sunitinib exposure in patients with GIST.

scientific article

Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan

scientific article published in November 2005

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

scientific article

Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis.

scientific article

Efficacy of pazopanib and sunitinib in advanced axial chordoma: a single reference centre case series

scientific article

Emphasizing the value of phenotyping in patients receiving tamoxifen

scientific article published on 19 December 2011

Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial.

scientific article published on 10 February 2016

Etoposide and carbo-or cisplatin combination therapy in refractory or relapsed Ewing sarcoma: A large retrospective study

scholarly article by Annemiek M. van Maldegem et al published 22 September 2014 in Pediatric Blood Cancer

Evaluation of KDR rs34231037 as a predictor of sunitinib efficacy in patients with metastatic renal cell carcinoma.

scientific article published on 20 April 2017

Evaluation of Quality of Life at Progression in Patients with Soft Tissue Sarcoma

scientific article

Evaluation of an oral uracil loading test to identify DPD-deficient patients using a limited sampling strategy

scientific article published on 9 November 2015

Evaluation of clinical implementation of prospective DPYD genotyping in 5-fluorouracil- or capecitabine-treated patients

scientific article

Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study

scientific article published on 01 August 2020

Everolimus in Patients With Advanced Follicular-Derived Thyroid Cancer: Results of a Phase II Clinical Trial

scientific article published on 01 February 2017

Ewing sarcoma: The clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathway.

scientific article

Excision Repair Cross-Complementation group 1 (ERCC1) C118T SNP does not affect cellular response to oxaliplatin

scientific article published on 9 November 2013

Exposure-response analysis of endoxifen serum concentrations in early-breast cancer

scientific article published on 29 May 2020

Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo

scientific article

Extra-abdominal subcutaneous metastasis of a gastrointestinal stromal tumor: report of a case and a review of the literature.

scientific article published on 06 October 2008

Gastrointestinal Stromal Tumours (GIST) in Young Adult (18-40 Years) Patients: A Report from the Dutch GIST Registry

scientific article published on 20 March 2020

Genetic Variants in DNA Repair Pathways as Potential Biomarkers in Predicting Treatment Outcome of Intraperitoneal Chemotherapy in Patients With Colorectal Peritoneal Metastasis: A Systematic Review

scientific article published on 06 October 2020

Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib

scientific article published on 19 November 2010

Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors

scientific article published on 04 February 2019

Genetic polymorphisms in angiogenesis-related genes are associated with worse progression-free survival of patients with advanced gastrointestinal stromal tumours treated with imatinib.

scientific article

Genome Wide Association Study for Predictors of Progression Free Survival in Patients on Capecitabine, Oxaliplatin, Bevacizumab and Cetuximab in First-Line Therapy of Metastatic Colorectal Cancer

scientific article published on 29 July 2015

Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab

scientific article published in PLoS ONE

Germline variants in the CYP19A1 gene are related to specific adverse events in aromatase inhibitor users: a substudy of Dutch patients in the TEAM trial

article

Giant cell tumour of bone in the denosumab era.

scientific article published on 30 March 2017

Glutathione-S-transferase pi (GSTP1) codon 105 polymorphism is not associated with oxaliplatin efficacy or toxicity in advanced colorectal cancer patients

scientific article

High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008

scientific article published on 25 September 2019

High-Dose Chemotherapy and Blood Autologous Stem-Cell Rescue Compared With Standard Chemotherapy in Localized High-Risk Ewing Sarcoma: Results of Euro-E.W.I.N.G.99 and Ewing-2008

article by Jeremy Whelan et al published 6 September 2018 in Journal of Clinical Oncology

Higher incidence rates than previously known in tenosynovial giant cell tumors.

scientific article published on 8 August 2017

Histone deacetylase inhibitors: an overview of the clinical studies in solid tumors

scientific article published on February 2014

Home treatment of patients with cancer-associated venous thromboembolism - An evaluation of daily practice

scientific article published on 04 November 2019

Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor

scientific article

Imatinib in combination with phosphoinositol kinase inhibitor buparlisib in patients with gastrointestinal stromal tumour who failed prior therapy with imatinib and sunitinib: a Phase 1b, multicentre study

scientific article published on 09 March 2020

Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials

scientific article

Imatinib-induced agranulocytosis in patients with gastrointestinal stromal tumors.

scientific article

Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients

scientific article published on 01 May 2019

Impact of Concomitant Administration of Gastric Acid-Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials

scientific article published on 14 February 2019

Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults

scientific article published on 10 August 2016

Impact of chemotherapy-induced nausea and vomiting on quality of life in indonesian patients with gynecologic cancer

scientific article

Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: secondary analysis of the Euro-Ewing99-R1 trial

scientific article published on 10 August 2015

In reply

In vitro schedule-dependent interaction between melphalan and oxaliplatin in human colorectal cancer cell lines

scientific article

Incidence and demographics of giant cell tumor of bone in The Netherlands: First nationwide Pathology Registry Study

scientific article published on 10 July 2018

Individualized dosing of fluoropyrimidine-based chemotherapy to prevent severe fluoropyrimidine-related toxicity - What are the options?

scientific article published on 05 October 2020

Individualized dosing of tyrosine kinase inhibitors: are we there yet?

scientific article published on 22 September 2014

Influence of CYP2C8 polymorphisms on imatinib steady-state trough level in chronic myeloid leukemia and gastrointestinal stromal tumor patients

scientific article published on 5 April 2017

Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib

scientific article

Influence of Cremophor El on the bioavailability of intraperitoneal paclitaxel

scientific article published in April 2002

Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.

scientific article

Influence of metastatic disease on the usefulness of uracil pharmacokinetics as a screening tool for DPD activity in colorectal cancer patients

scientific article published on 10 May 2015

Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib

scientific article

Inhibition of Bcl-2 family members sensitises soft tissue leiomyosarcomas to chemotherapy

scientific article published on 3 May 2016

Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line

scientific article published on 12 September 2016

Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01)

scientific article

Intact interferon signaling in peripheral blood leukocytes of high-grade osteosarcoma patients

scientific article

International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours - EURO EWING 2012 Protocol

scientific article published on 17 January 2020

Intrapatient cetuximab dose escalation in metastatic colorectal cancer according to the grade of early skin reactions: the randomized EVEREST study

scientific article

Intrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib

scientific article published on 22 November 2019

Is rectal administration an alternative route for imatinib?

scientific article published on 08 February 2007

Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases

scientific article published on 28 June 2017

Liposomal drug formulations in cancer therapy: 15 years along the road

scientific article published on 29 September 2011

Long-term outcomes of pexidartinib in tenosynovial giant cell tumors

scientific article published on 16 November 2020

MTHFR polymorphisms and capecitabine-induced toxicity in patients with metastatic colorectal cancer

scientific article published in April 2013

Mammalian target of rapamycin inhibitor-associated stomatitis

scientific article

Marginal increase of sunitinib exposure by grapefruit juice

scientific article

Meta-analysis on the association of VEGFR1 genetic variants with sunitinib outcome in metastatic renal cell carcinoma patients

scientific article

Method to measure the mismatch between target and achieved received dose intensity of chemotherapy in cancer trials: a retrospective analysis of the MRC BO06 trial in osteosarcoma

scientific article published on 30 May 2019

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good R

scientific article

Mitotane has a strong and a durable inducing effect on CYP3A4 activity.

scientific article

Molecular oncogenesis of chondrosarcoma: impact for targeted treatment.

scientific article published on 10 May 2016

Multicenter comparison of Molecular Tumor Boards in the Netherlands: definition, composition, methods and targeted therapy recommendations

scientific article published on 28 October 2020

NK cells recognize and lyse Ewing sarcoma cells through NKG2D and DNAM-1 receptor dependent pathways

scientific article

Neoadjuvant denosumab for extensive giant cell tumor in os ischium: a case report

scientific article

New benchmarks to design clinical trials with advanced or metastatic liposarcoma or synovial sarcoma patients: An EORTC – Soft Tissue and Bone Sarcoma Group (STBSG) meta-analysis based on a literature review for soft-tissue sarcomas

scientific article published in 2022

New systemic therapy options for advanced sarcomas

scientific article

Nilotinib in locally advanced pigmented villonodular synovitis: a multicentre, open-label, single-arm, phase 2 trial

scientific article published on 20 March 2018

Oral adverse events associated with tyrosine kinase and mammalian target of rapamycin inhibitors in renal cell carcinoma: a structured literature review

scientific article published on 29 December 2011

Osteosarcoma of the hands and feet: a distinct clinico-pathological subgroup.

scientific article published on 5 December 2012

Osteosarcoma: Evolution of Treatment Paradigms ⬇️

scientific article published on May 27, 2013

Outcome of First-Line Systemic Treatment for Unresectable Conventional, Dedifferentiated, Mesenchymal, and Clear Cell Chondrosarcoma

scientific article published on 06 August 2018

Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis: A Population-Based Study in the Netherlands

scientific article published on 21 June 2018

Outcome of advanced, unresectable conventional central chondrosarcoma.

scientific article published on 3 July 2014

Outcome of chemotherapy in advanced synovial sarcoma patients: Review of 15 clinical trials from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group; setting a new landmark for studies in this entity

scientific article

Outcomes of Elderly Patients with Advanced Soft Tissue Sarcoma Treated with First-Line Chemotherapy: A Pooled Analysis of 12 EORTC Soft Tissue and Bone Sarcoma Group Trials.

scientific article published on 12 April 2018

PD-1 Blockade in Anaplastic Thyroid Carcinoma

scientific article published on 04 May 2020

Panobinostat-A Potential Treatment for Metastasized Ewing Sarcoma? A Case Report

scientific article published on 01 June 2016

Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial

scientific article

Perioperative Management of Extremity Soft Tissue Sarcomas.

scientific article published on 8 December 2017

Pexidartinib long-term hepatic safety profile in TGCT patients

scientific article published on 08 December 2020

Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial

scientific article published on 19 June 2019

Pexidartinib: first approved systemic therapy for patients with tenosynovial giant cell tumor

scientific article published on 23 July 2020

Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity

scientific article published on 10 September 2009

Pharmacogenetics in chemotherapy of colorectal cancer

scientific article published on January 2009

Pharmacogenetics of EGFR and VEGF inhibition

scientific article

Pharmacogenetics of small-molecule tyrosine kinase inhibitors: Optimizing the magic bullet.

scientific article published on December 2010

Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors

scientific article

Pharmacogenetics of tomorrow: the 1 + 1 = 3 principle

scientific article published in July 2010

Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors.

scientific article published on 27 July 2009

Phase I pharmacokinetic and pharmacodynamic study of the aurora kinase inhibitor danusertib in patients with advanced or metastatic solid tumors

scientific article published on 21 September 2009

Phase I pharmacological and bioavailability study of oral diflomotecan (BN80915), a novel E-ring-modified camptothecin analogue in adults with solid tumors

scientific article published in September 2003

Phase II multicenter clinical trial of pulmonary metastasectomy and isolated lung perfusion with melphalan in patients with resectable lung metastases

scientific article

Phenotyping drug disposition in oncology

scientific article published on 04 January 2012

Pneumothorax as adverse event in patients with lung metastases of soft tissue sarcoma treated with pazopanib: a single reference centre case series

scientific article

Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors

scientific article published on 11 October 2020

Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing

scientific article published on 30 June 2020

Pre-therapeutic UGT1A1 genotyping to reduce the risk of irinotecan-induced severe toxicity: Ready for prime time

scientific article published on 23 October 2020

Predictors for doxorubicin-induced hematological toxicity and its association with outcome in advanced soft tissue sarcoma patients; a retrospective analysis of the EORTC-soft tissue and bone sarcoma group database

scientific article published on 09 March 2018

Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial

scientific article published on 14 September 2020

Presence of chemotherapy-induced toxicity predicts improved survival in patients with localised extremity osteosarcoma treated with doxorubicin and cisplatin: a report from the European Osteosarcoma Intergroup.

scientific article

Primary Ewing sarcoma of the iris.

scientific article published on 16 August 2013

Prognostic factors for soft tissue sarcoma patients with lung metastases only who are receiving first-line chemotherapy: An exploratory, retrospective analysis of the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sa

scientific article published on 31 January 2018

Prognostic factors in pulmonary metastasized high-grade osteosarcoma.

scientific article published in February 2010

Prospective DPYD genotyping to reduce the risk of fluoropyrimidine-induced severe toxicity: Ready for prime time.

scientific article published on 21 December 2015

Quality of Life and Utility in Patients with Metastatic Soft Tissue and Bone Sarcoma: The Sarcoma Treatment and Burden of Illness in North America and Europe (SABINE) Study

scientific article published on 20 March 2012

Quality of Surgery and Outcome in Localized Gastrointestinal Stromal Tumors Treated Within an International Intergroup Randomized Clinical Trial of Adjuvant Imatinib

scientific article published on 01 April 2020

Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013-14) trial

scientific article published on 11 November 2020

Quality of treatment and surgical approach for rectal gastrointestinal stromal tumour (GIST) in a large European cohort

scientific article published on 06 March 2020

RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline

scientific article

Radiation-induced Sarcomas Occurring in Desmoid-type Fibromatosis Are Not Always Derived From the Primary Tumor

scientific article published in December 2015

Randomised study of tegafur-uracil plus leucovorin versus capecitabine as first-line therapy in elderly patients with advanced colorectal cancer--TLC study.

scientific article

Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage?

scientific article published on 26 February 2018

Red blood cells: a neglected compartment in topotecan pharmacokinetic analysis

scientific article published in March 2003

Replication of a genetic variant in ACYP2 associated with cisplatin-induced hearing loss in patients with osteosarcoma.

scientific article

Reply to C.L. Braal et al, H. Brauch et al, and M.P. Goetz et al

scientific article published on 18 June 2019

Reply to R. Ferraldeschi et al

Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomised, placebo-controlled, phase 3 trial

scientific article published on 05 June 2020

SNPs and haplotypes in DPYD and outcome of capecitabine--Letter

scientific article published on 30 August 2011

Safety and efficacy of Pazopanib in advanced soft tissue sarcoma: PALETTE (EORTC 62072) subgroup analyses

scientific article published on 13 August 2019

Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients

scientific article published in September 2015

Serum levels of IGF-1 and IGF-BP3 are associated with event-free survival in adult Ewing sarcoma patients treated with chemotherapy

scientific article published on 13 June 2017

Several patients with a metastasised gastrointestinal stroma-cell tumor for whom the tide turned by the introduction of imatinib

scientific article published on October 18, 2003

Single-Center Experience with Ifosfamide Monotherapy as Second-Line Treatment of Recurrent/Metastatic Osteosarcoma

scientific article published on 19 December 2019

Skeletal retention of bisphosphonate (pamidronate) and its relation to the rate of bone resorption in patients with breast cancer and bone metastases

scientific article published on 31 May 2005

Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: an update of recent developments

scientific article published on 14 November 2006

Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination

scientific article published on 19 May 2010

Standard fluoropyrimidine dosages in chemoradiation therapy result in an increased risk of severe toxicity in DPYD variant allele carriers

article

Statin use is not associated with improved progression free survival in cetuximab treated KRAS mutant metastatic colorectal cancer patients: results from the CAIRO2 study

scientific article

Stromal organization as predictive biomarker for the treatment of colon cancer with adjuvant bevacizumab; a post-hoc analysis of the AVANT trial

scientific article published on 17 May 2019

Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1-mutated or IDH2-mutated solid tumours

scientific article published on 10 June 2017

Surgery after treatment with imatinib and/or sunitinib in patients with metastasized gastrointestinal stromal tumors: is it worthwhile?

scientific article

Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study

scientific article published on 24 April 2019

Surgical treatment of locally advanced, non-metastatic, gastrointestinal stromal tumours after treatment with imatinib ⬇️

scientific article published on October 16, 2012

Surrogate endpoints in advanced sarcoma trials: a meta-analysis

scientific article published on 02 October 2018

Survival after adjuvant 5-FU treatment for stage III colon cancer in hereditary nonpolyposis colorectal cancer.

scientific article published in April 2004

Survival after recurrent osteosarcoma: data from 3 European Osteosarcoma Intergroup (EOI) randomized controlled trials

scientific article

Survival and Cost-Effectiveness of Trabectedin Compared to Ifosfamide Monotherapy in Advanced Soft Tissue Sarcoma Patients

scientific article published on 02 June 2019

Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort

scientific article published on 25 January 2019

Survival of soft tissue sarcoma patients after completing six cycles of first-line anthracycline containing treatment: an EORTC-STBSG database study

scientific article published on 09 September 2020

Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib

scientific article published on 17 August 2020

Systemic therapy of advanced/metastatic gastrointestinal stromal tumours: an update on progress beyond imatinib, sunitinib and regorafenib

scientific article published on 30 November 2020

Systemic treatments in MDM2 positive intimal sarcoma: A multicentre experience with anthracycline, gemcitabine, and pazopanib within the World Sarcoma Network

scientific article published on 19 September 2019

Tales of How Great Drugs Were Brought Down by a Flawed Rationale—Letter ⬇️

scientific article published on February 7, 2013

Tamoxifen Pharmacogenetics and Metabolism: Results From the Prospective CYPTAM Study

scientific article published on 24 January 2019

Telatinib Is an Effective Targeted Therapy for Pseudomyogenic Hemangioendothelioma.

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The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report

scientific article published on 16 March 2016

The Effect of Using Pazopanib With Food vs. Fasted on Pharmacokinetics, Patient Safety, and Preference (DIET Study)

scientific article published on 09 July 2019

The clinical approach toward giant cell tumor of bone

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The clinical approach towards chondrosarcoma

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The effect of rs5758550 on CYP2D6*2 phenotype and formation of endoxifen in breast cancer patients using tamoxifen

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The fate of camptothecin glycoconjugate: report of a clinical hold during a phase II study of BAY 56-3722 (formerly BAY 38-3441), in patients with recurrent or metastatic colorectal cancer resistant/refractory to irinotecan ⬇️

scientific article published on May 6, 2011

The impact of chemotherapy on survival of patients with extremity and trunk wall soft tissue sarcoma: revisiting the results of the EORTC-STBSG 62931 randomised trial

scientific article published on 25 January 2019

The tumour-stroma ratio in colon cancer; the biological role and its prognostic impact.

scientific article published on 19 February 2018

Therapeutic drug monitoring to individualize the dosing of pazopanib: a pharmacokinetic feasibility study

scientific article published on 01 June 2015

Therapeutic modulation of k-ras signaling in colorectal cancer

scientific article published on 02 June 2010

Therapy-Related Imaging Findings in Patients with Sarcoma

scientific article published on 11 December 2020

Time to Definitive Failure to the First Tyrosine Kinase Inhibitor in Localized GI Stromal Tumors Treated With Imatinib As an Adjuvant: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Intergroup Randomi

scientific article published on 16 November 2015

Tissue factor associates with survival and regulates tumour progression in osteosarcoma.

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Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score

scientific article published on 12 August 2015

Translating pharmacogenomics: challenges on the road to the clinic

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Translation and linguistic validation of the FACT-EGFRI-18 quality of life instrument from English into Dutch

scientific article published on 06 April 2013

Translation and validation of EORTC QLQ-C30 into Indonesian version for cancer patients in Indonesia.

scientific article published on 25 January 2011

Treatment patterns and clinical outcomes with pazopanib in patients with advanced soft tissue sarcomas in a compassionate use setting: results of the SPIRE study().

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Unraveling the Resistance of IGF-Pathway Inhibition in Ewing Sarcoma

scientific article published on 29 November 2020

Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma

scientific article published on 26 August 2013

Which Factors Are Associated with Local Control and Survival of Patients with Localized Pelvic Ewing's Sarcoma? A Retrospective Analysis of Data from the Euro-EWING99 Trial

scientific article published on 01 February 2020

Workshop Report on the European Bone Sarcoma Networking Meeting: Integration of Clinical Trials with Tumor Biology

scientific article published in September 2011

Workshop report on the 2nd Joint ENCCA/EuroSARC European bone sarcoma network meeting: integration of clinical trials with tumour biology

scientific article published in May 2014

γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

scientific article published in 2023

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