List of works - W. Bret Church

A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2

scientific article published on 18 November 2020

A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats.

scientific article published on 26 July 2002

A novel approach to the design of inhibitors of human secreted phospholipase A2 based on native peptide inhibition

scientific article published on 26 June 2001

Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids.

scientific article published on 27 December 2010

BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state

scientific article published in PLoS ONE

Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted β propeller domain

scientific article published on 01 December 1999

Comparative modeling of marsupial MHC class I molecules identifies structural polymorphisms affecting functional motifs

scientific article published on 01 November 2007

Crystallization and preliminary X-ray diffraction studies of a new crystal form of human secretory type IIA phospholipase A2

scientific article published on 01 November 2000

Crystallization of human beta-hexosaminidase B

scientific article published on September 20, 1992

Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I

scientific article published on 10 January 2012

Essential structural features of novel antischizophrenic drugs: a review

scientific article published on January 2014

Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set.

scientific article

Fragment Screening of Human Kynurenine Aminotransferase-II

scientific article published on 14 March 2018

Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2

scientific article published on 06 August 2013

High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate

scientific article published on 18 January 2017

Homology modeling of human kynurenine aminotransferase III and observations on inhibitor binding using molecular docking.

scientific article published in January 2014

Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters.

scientific article published on 24 April 2018

In silico evaluation of the influence of the translocon on partitioning of membrane segments.

scientific article

Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives

scientific article published on 14 December 2017

Kink characterization and modeling in transmembrane protein structures.

scientific article published on 29 October 2013

Kynurenine Aminotransferase Isozyme Inhibitors: A Review

scientific article

Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia

scientific article published on 07 June 2015

Marked differences in the structures and protein associations of lymphocyte and monocyte CD4: resolution of a novel CD4 isoform.

scientific article published on April 2006

Modelling the structures of G protein-coupled receptors aided by three-dimensional validation.

scientific article

Molecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificity

scientific article published on 01 April 2002

Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance.

scientific article

Neutron scattering shows a droplet of oleic acid at the center of the BAMLET complex

scientific article published on 5 April 2017

Phage display as a technology delivering on the promise of peptide drug discovery.

scientific article

Prediction of rotational orientation of transmembrane helical segments of integral membrane proteins using new environment-based propensities for amino acids derived from structural analyses

scientific article published on 19 April 2007

Relating structure to function in the beta-propeller domain of dipeptidyl peptidase IV. Point mutations that influence adenosine deaminase binding, antibody binding and enzyme activity.

scientific article

Rhodopsin: structure, signal transduction and oligomerisation.

scientific article published on 03 August 2008

Selective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes

scientific article

Small-angle X-ray scattering of BAMLET at pH 12: a complex of α-lactalbumin and oleic acid.

scientific article published on 25 January 2014

Structural and functional consequences of succinate dehydrogenase subunit B mutations.

scientific article published in June 2015

Structural modelling and dynamics of proteins for insights into drug interactions.

scientific article

Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components

Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders.

scientific article published on 29 June 2016

The dipeptidyl peptidase IV family in cancer and cell biology.

scientific article published on 13 January 2010

The function of conserved amino acid residues adjacent to the effector domain in elongation factor G

scientific article published on 01 November 1999

The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis

scientific article published in September 2011

The molecular structure of the IsiA–Photosystem I supercomplex, modelled from high-resolution, crystal structures of Photosystem I and the CP43 protein

scientific article published on 11 January 2010

The use of soluble protein structures in modeling helical proteins in a layered membrane

scientific article published on 25 March 2013

List of works by W. Bret Church

A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2

A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats.

A novel approach to the design of inhibitors of human secreted phospholipase A2 based on native peptide inhibition

Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids.

BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state

Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted β propeller domain

Comparative modeling of marsupial MHC class I molecules identifies structural polymorphisms affecting functional motifs

Crystallization and preliminary X-ray diffraction studies of a new crystal form of human secretory type IIA phospholipase A2

Crystallization of human beta-hexosaminidase B

Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I

Essential structural features of novel antischizophrenic drugs: a review

Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set.

Fragment Screening of Human Kynurenine Aminotransferase-II

Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2

High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate

Homology modeling of human kynurenine aminotransferase III and observations on inhibitor binding using molecular docking.

Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters.

In silico evaluation of the influence of the translocon on partitioning of membrane segments.

Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives

Kink characterization and modeling in transmembrane protein structures.

Kynurenine Aminotransferase Isozyme Inhibitors: A Review

Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia

Marked differences in the structures and protein associations of lymphocyte and monocyte CD4: resolution of a novel CD4 isoform.

Modelling the structures of G protein-coupled receptors aided by three-dimensional validation.

Molecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificity

Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance.

Neutron scattering shows a droplet of oleic acid at the center of the BAMLET complex

Phage display as a technology delivering on the promise of peptide drug discovery.

Prediction of rotational orientation of transmembrane helical segments of integral membrane proteins using new environment-based propensities for amino acids derived from structural analyses

Relating structure to function in the beta-propeller domain of dipeptidyl peptidase IV. Point mutations that influence adenosine deaminase binding, antibody binding and enzyme activity.

Rhodopsin: structure, signal transduction and oligomerisation.

Selective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes

Small-angle X-ray scattering of BAMLET at pH 12: a complex of α-lactalbumin and oleic acid.

Structural and functional consequences of succinate dehydrogenase subunit B mutations.

Structural modelling and dynamics of proteins for insights into drug interactions.

Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components

Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders.

The dipeptidyl peptidase IV family in cancer and cell biology.

The function of conserved amino acid residues adjacent to the effector domain in elongation factor G

The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis

The molecular structure of the IsiA–Photosystem I supercomplex, modelled from high-resolution, crystal structures of Photosystem I and the CP43 protein

The use of soluble protein structures in modeling helical proteins in a layered membrane