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List of works by Jan Frystyk

36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

scientific article

A Comparison of Pharmacokinetics and Pharmacodynamics of Insulin Aspart, Biphasic Insulin Aspart 70, Biphasic Insulin Aspart 50, and Human Insulin: A Randomized, Quadruple Crossover Study ⬇️

scientific article published on April 20, 2012

A novel algorithm for prediction and detection of hypoglycemia based on continuous glucose monitoring and heart rate variability in patients with type 1 diabetes

scientific article published on 31 March 2014

A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome

scientific article

Adiponectin and lipoprotein particle size

scientific article published on 23 April 2009

Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin

scientific article published on 09 July 2009

Age- and sex-specific reference intervals across life span for insulin-like growth factor binding protein 3 (IGFBP-3) and the IGF-I to IGFBP-3 ratio measured by new automated chemiluminescence assays

scientific article published on 31 January 2014

Aging somatotropic axis: mechanisms and implications of insulin-like growth factor-related binding protein adaptation

scientific article

Are Changes in Heart Rate Variability During Hypoglycemia Confounded by the Presence of Cardiovascular Autonomic Neuropathy in Patients with Diabetes?

scientific article published on February 2017

Assessment of ghrelin

scientific article

Association of serum adiponectin with risk for cardiovascular events in patients with peripheral arterial disease

scientific article

Associations of serum adiponectin with skeletal muscle morphology and insulin sensitivity

scientific article

Bioactive insulin-like growth factor (IGF) I and IGF-binding protein-1 in anorexia nervosa

scientific article

Body mass index in chronic heart failure: association with biomarkers of neurohormonal activation, inflammation and endothelial dysfunction.

scientific article

Changes in adipokines after transjugular intrahepatic porto-systemic shunt indicate an anabolic shift in metabolism

scientific article published on 27 April 2012

Characterisation of adiponectin multimers and the IGF axis in humans with a heterozygote mutation in the tyrosine kinase domain of the insulin receptor gene ⬇️

scientific article published on December 21, 2011

Circulating levels of IGF-1 directly regulate bone growth and density

scientific article

Combining information of autonomic modulation and CGM measurements enables prediction and improves detection of spontaneous hypoglycemic events

scientific article published on 12 September 2014

Comparison of Osteoprotegerin to Traditional Atherosclerotic Risk Factors and High-Sensitivity C-Reactive Protein for Diagnosis of Atherosclerosis ⬇️

scientific article published on November 17, 2011

Comparison of plasma metanephrines measured by a commercial immunoassay and urinary catecholamines in the diagnosis of pheochromocytoma ⬇️

scientific article published on October 24, 2011

Conventional and novel biomarkers of treatment outcome in patients with acromegaly: discordant results after somatostatin analog treatment compared with surgery.

scientific article published on 2 September 2010

Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue

scientific article published on 2 February 2018

Determination of IGFs and their binding proteins.

scientific article published on 06 September 2013

Determination of free growth hormone

scientific article published on 20 May 2008

Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5

scientific journal article

Early Pregnancy-Associated Plasma Protein A Concentrations Are Associated With Third Trimester Insulin Sensitivity

scientific article published on 13 March 2017

Early elective insulin therapy can reduce hyperglycemia and increase insulin-like growth factor-I levels in very low birth weight infants

scientific article published on 10 August 2007

Effect of hyperinsulinemia during hemodialysis on the insulin-like growth factor system and inflammatory biomarkers: a randomized open-label crossover study

scientific article

Effects of carbohydrate restriction on postprandial glucose metabolism, beta-cell function, gut hormone secretion, and satiety in patients with type 2 diabetes

scientific article published on 26 October 2020

Effects of human insulin and insulin aspart preparations on levels of IGF-I, IGFBPs and IGF bioactivity in patients with type 1 diabetes

scientific article

Effects of ischemic pre- and postconditioning on HIF-1α, VEGF and TGF-β expression after warm ischemia and reperfusion in the rat liver

scientific article

Elevated levels of high-molecular-weight adiponectin in type 1 diabetes

scientific article published on 27 May 2008

Endurance Training and its Effect upon the Activity of the GH-IGFs System in the Elderly ⬇️

scientific article published on May 1, 1998

Evaluation of IGFBP-7 DNA methylation changes and serum protein variation in Swedish subjects with and without type 2 diabetes

scientific article

Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls

scientific article published in August 2006

Exercise and the growth hormone-insulin-like growth factor axis

scientific article published on January 2010

Fetal growth velocity, size in early life and adolescence, and prediction of bone mass: association to the GH-IGF axis

scientific article

Free insulin-like growth factors -- measurements and relationships to growth hormone secretion and glucose homeostasis

scientific article published in October 2004

GH activity and markers of inflammation: a crossover study in healthy volunteers treated with GH and a GH receptor antagonist ⬇️

scientific article published on March 9, 2012

Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations

scientific article

Growth hormone treatment for two years is safe and effective in adults with Prader-Willi syndrome ⬇️

scientific article published on June 12, 2011

Growth hormone treatment, final height, insulin-like growth factors, ghrelin, and adiponectin in four siblings with Seckel syndrome ⬇️

scientific article published on January 1, 2011

IGF-I and IGFBP2 in peripheral artery disease: results of a prospective study

scientific article published on 18 March 2014

IL-6 has no acute effect on the regulation of urea synthesisin vivoin rats

scientific article published on 30 December 2010

Impact of fasting on growth hormone signaling and action in muscle and fat.

scientific article published on 9 December 2008

Increased levels of circulating free insulin-like growth factors in patients with non-islet cell tumour hypoglycaemia ⬇️

scientific article published on May 1, 1998

Insulin growth factor binding proteins as therapeutic targets in type 2 diabetes

scientific article

Insulin, IGF-1, and GH Receptors Are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice With Modified GH Action.

scientific article published on 27 February 2017

Insulin-Like Growth Factor Binding Protein 4 Fragments Provide Incremental Prognostic Information on Cardiovascular Events in Patients With ST-Segment Elevation Myocardial Infarction

scientific article published on 17 March 2017

Interaction between leptin and leisure-time physical activity and development of hypertension ⬇️

scientific article published on October 24, 2011

Interferon-β treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis

scientific article published on 27 September 2010

Leptin, ghrelin, and endocannabinoids: potential therapeutic targets in anorexia nervosa

scientific article published on 15 October 2008

Low IGF-I and elevated testosterone during puberty in subjects with type 1 diabetes developing microalbuminuria in comparison to normoalbuminuric control subjects: the Oxford Regional Prospective Study

scientific article published in May 2003

Markers of inflammation in relation to long-term cardiovascular mortality in patients with lower-extremity peripheral arterial disease

scientific article published on 03 April 2011

Masculinising testosterone treatment and effects on preclinical cardiovascular disease, muscle strength and power, aggression, physical fitness and respiratory function in transgender men: protocol for a 10-year, prospective, observational cohort st

scientific article published on 29 December 2020

Measurement of free GH and bioactive IGF-I in non-diabetic haemodialysis patients treated with GH for 7 days ⬇️

scientific article published on August 21, 2012

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability

scientific article published on 22 February 2016

Novel cardiovascular risk markers in depression: No association between depressive symptoms and osteoprotegerin or adiponectin in persons at high risk for sleep apnea ⬇️

scientific article published on August 3, 2012

Obesity and cancer risk: the role of the insulin-IGF axis

scientific article published on 7 September 2006

Osteoprotegerin Predicts Long-Term Outcome in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention ⬇️

scientific article published on 07 September 2012

PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma

scientific article published on 24 August 2015

Pioglitazone treatment increases spontaneous growth hormone (GH) secretion and stimulated GH levels in polycystic ovary syndrome

scientific article published on 2 August 2005

Plasma alpha-defensin is associated with cardiovascular morbidity and mortality in type 1 diabetic patients

scientific article published on 22 January 2008

Prednisolone but Not Infliximab Aggravates the Upregulated Hepatic Nitrogen Elimination in Patients with Active Inflammatory Bowel Disease

scientific article published on 01 January 2014

Prednisolone reduces the ability of serum to activate the IGF1 receptor in vitro without affecting circulating total or free IGF1 ⬇️

scientific article published on December 10, 2012

Prognostic relevance and performance characteristics of serum IGFBP-2 and PAPP-A in women with breast cancer: a long-term Danish cohort study.

scientific article

Quantification of the GH/IGF-axis components: Lessons from human studies ⬇️

scientific article published on November 24, 2011

Reference intervals for insulin-like growth factor-1 (igf-i) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations

scientific article

Relation of Serum Adiponectin Levels to Number of Traditional Atherosclerotic Risk Factors and All-Cause Mortality and Major Adverse Cardiovascular Events (from the Copenhagen City Heart Study) ⬇️

scientific article published on 01 February 2013

Serum Adiponectin in Elderly Men Does Not Correlate with Fracture Risk

scientific article published on 22 July 2008

Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes

scientific article

Serum adiponectin is a predictor of coronary heart disease: a population-based 10-year follow-up study in elderly men.

scientific article published on 21 November 2006

Serum adiponectin is increased in type 1 diabetic patients with nephropathy

scientific article published in June 2005

Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy

scientific article published on 21 May 2008

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism

scientific article published on 24 October 2008

Serum free IGF-I during a hyperinsulinemic clamp following 3 days of administration of IGF-I vs. saline ⬇️

scientific article published on September 1, 1997

Sex-discordant associations with adiponectin levels and lipid profiles in children

scientific article published in May 2006

Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency

scientific article

Soluble membrane attack complex in ascites in patients with liver cirrhosis without infections

scientific article

Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations

scientific article

The Circulating IGF System in Hepatocellular Carcinoma: The Impact of Liver Status and Treatment

scientific article

The Effect of Oral Glucose on Serum Free Insulin-Like Growth Factor-I and -II in Healthy Adults* ⬇️

scientific article published on September 1, 1997

The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage.

scientific article published on 8 February 2017

The current status of IGF-I assays--a 2009 update

scientific article published on 08 October 2009

The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy

scientific article

The role of insulin-like growth factor (IGF) binding protein-2 in the insulin-mediated decrease in IGF-I bioactivity

scientific article published on 21 October 2009

Tissue IGF-I Measured by Microdialysis Reflects Body Glucose Utilization After rhIGF-I Injection in Type 1 Diabetes.

scientific article

Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome

scientific article

Unbound (bioavailable) IGF1 enhances somatic growth.

scientific article

Urinary adiponectin excretion rises with increasing albuminuria in type 1 diabetes

scientific article published on 20 August 2013

Usefulness of Adiponectin as a Predictor of All Cause Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention ⬇️

scientific article published on November 19, 2011

Utility of free IGF-I measurements

scientific article published on January 2007

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