Search filters

List of works by Thomas Freret

5-HT6 receptor antagonists as treatment for age-related cognitive decline

scientific article published on January 2014

A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat

scientific article

Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment.

scientific article

Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.

scientific article

Asc-1 transporter activation: an alternative to rescue age-related alterations in functional plasticity at rat hippocampal CA3/CA1 synapses

scientific article published on 06 November 2018

Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal test.

scientific article

Benzodiazepines increase the reward effects of buprenorphine in a conditioned place preference test in the mouse

scientific article published on 17 April 2014

Characterizing age-related decline of recognition memory and brain activation profile in mice

scientific article published on 7 March 2018

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances

scientific article

Clinical isolates of Trichomonas vaginalis concurrently infected by strains of up to four Trichomonasvirus species (Family Totiviridae)

scientific article

Combined Therapeutic Strategy Using Erythropoietin and Mesenchymal Stem Cells Potentiates Neurogenesis after Transient Focal Cerebral Ischemia in Rats

scientific article published on 14 May 2008

Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals

scientific article published on 17 April 2011

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat.

scientific article

Delayed hypoxic postconditioning protects against cerebral ischemia in the mouse

scientific article

Donecopride, a Swiss army knife with potential against Alzheimer's disease

scientific article published on 27 December 2019

Dual histamine H3R/serotonin 5-HT4R ligands with antiamnesic properties: pharmacophore-based virtual screening and polypharmacology

scientific article

Effect of hypoxic preconditioning on brain genomic response before and following ischemia in the adult mouse: identification of potential neuroprotective candidates for stroke

scientific article

Effect of pre- versus post-weaning environmental disturbances on social behaviour in mice.

scientific article

Effects of acute administration of melatonin on attentional, executive, and working memory processes in rats.

scientific article published on 20 July 2015

Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis

scientific article published on 28 April 2015

Environmental Enrichment Duration Differentially Affects Behavior and Neuroplasticity in Adult Mice.

scientific article

Environmental enrichment enhances episodic-like memory in association with a modified neuronal activation profile in adult mice

scientific article

Environmental enrichment improves recent but not remote memory in association with a modified brain metabolic activation profile in adult mice.

scientific article published on 28 November 2011

Genomic transcriptional profiling in LOU/C/Jall rats identifies genes for successful aging.

scientific article

Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat.

scientific article published on 24 May 2012

Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors

scientific article published on April 27, 2011

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease

scientific article published on 31 July 2019

Interplay between 5-HT4 Receptors and GABAergic System within CA1 Hippocampal Synaptic Plasticity

scientific article published on 16 September 2020

Intraluminal thread model of focal stroke in the non-human primate

scientific article published on 14 November 2007

Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease.

scientific article published in May 2014

Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis

scientific article published on 22 September 2020

Long-term evaluation of sensorimotor and mnesic behaviour following striatal NMDA-induced unilateral excitotoxic lesion in the mouse

scientific article

Long-term functional outcome following transient middle cerebral artery occlusion in the rat: correlation between brain damage and behavioral impairment

scientific article published in December 2006

Maternal hypertension during pregnancy modifies the response of the immature brain to hypoxia-ischemia: sequential MRI and behavioral investigations

scientific article

Mechanisms underlying the neuroprotective effect of brain reserve against late life depression.

scientific article published on 05 January 2014

New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: synthesis and antinociceptive evaluation

scientific article published on 13 September 2013

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride

scientific article published on 31 March 2015

Object recognition test in mice.

scientific article published on 21 November 2013

On the importance of long-term functional assessment after stroke to improve translation from bench to bedside.

scientific article published on 18 June 2011

Post-stroke depression: mechanisms, translation and therapy

scientific article published on September 2012

Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the rat.

scientific article published on 27 March 2010

Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate

scientific article

Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain adrenomedullin gene expression

scientific article published on 7 February 2012

Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan.

scientific article

Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse.

scientific article published on 24 October 2006

Serine Racemase Deletion Affects the Excitatory/Inhibitory Balance of the Hippocampal CA1 Network

scientific article published on 11 December 2020

Spatial and non-spatial performance in mutant mice devoid of otoliths.

scientific article published on 15 June 2012

Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors

scientific article

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

scientific article

Synthesis and preliminary in vivo evaluation of new 2-Aryl-6-methyl-1,2-dihydro-1H-pyridin-4-ones and 2-Aryl-6-methylpiperidin-4-ols, as potential anti-amnesiant agents.

scientific article published in December 2005

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice

scientific article published in October 2009

Therapeutic Potential of 5-HT6 Receptor Agonists.

scientific article published on 22 June 2015

Time decay of object, place and temporal order memory in a paradigm assessing simultaneously episodic-like memory components in mice.

scientific article published on 28 February 2015

Usefulness of Time-Point Serum Cortisol and ACTH Measurements for the Adjustment of Glucocorticoid Replacement in Adrenal Insufficiency

scientific article

Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation

scientific article published in June 2012