List of works - Gregory Towers

A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages

scientific article published on 25 January 2017

A model for cofactor use during HIV-1 reverse transcription and nuclear entry

scientific article

Abrogation of Ref1 retrovirus restriction in human cells

scientific article

Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation

scientific article

An active TRIM5 protein in rabbits indicates a common antiviral ancestor for mammalian TRIM5 proteins.

scientific article published on 29 August 2007

Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection

scientific article

Analysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin.

scientific article

Anti-retroviral innate immune responses in multiple lymphoid tissues elicited by protective live attenuated SIV vaccination.

scientific article published on 3 October 2011

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

scientific article

Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

scientific article published on 6 October 2017

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

scientific article

Characterization of murine leukemia virus restriction in mammals.

scientific article

Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

scientific article

Control of viral infectivity by tripartite motif proteins.

scientific article

Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity.

scientific article published on May 2006

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells

article

Cyclosporine increases human immunodeficiency virus type 1 vector transduction of primary mouse cells.

scientific article

DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages

scientific article

Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles

scientific article published on September 2005

Disease-associated XMRV sequences are consistent with laboratory contamination

scientific article

Diversity of TRIM5α and TRIMCyp sequences in cynomolgus macaques from different geographical origins.

scientific article

Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues

scientific article

Early potent protection against heterologous SIVsmE660 challenge following live attenuated SIV vaccination in Mauritian cynomolgus macaques.

scientific article

Early presentation of HIV-1 KF11Gag and KK10Gag protective epitopes facilitate rapid CD8+ T cell activation and killing of virus infected cells.

scientific article published on 13 September 2012

Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation

scientific article

Fusion of cyclophilin A to Fv1 enables cyclosporine-sensitive restriction of human and feline immunodeficiency viruses.

scientific article published on 3 July 2007

Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1.

scientific article published on 14 January 2014

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2

scientific article

HIV, cyclophilins and nuclear entry: going under the radar.

scientific article published on 3 October 2011

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF- κB/IRF3 nuclear transport

scientific article published on 10 December 2020

HIV-1 evades innate immune recognition through specific cofactor recruitment

scientific article

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

scientific article

Hepatitis C virus exploits cyclophilin A to evade PKR

scientific article published on 16 June 2020

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

article

Identification of a RELIK orthologue in the European hare (Lepus europaeus) reveals a minimum age of 12 million years for the lagomorph lentiviruses

scientific article (publication date: 5 February 2009)

Identification of the regions of Fv1 necessary for murine leukemia virus restriction.

scientific article

Identifying a nuclear passport for HIV

article

Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy

scientific article

Inhibition of retroviral replication by members of the TRIM protein family.

scientific article published on January 2013

Interactions between HIV-1 and the cell-autonomous innate immune system.

scientific article

KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control

scientific article published on 30 July 2018

Lentiviral gene therapy against human immunodeficiency virus type 1, using a novel human TRIM21-cyclophilin A restriction factor.

scientific article

MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface

scientific article published on 17 June 2020

No evidence of XMRV in prostate cancer cohorts in the Midwestern United States

scientific article

Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8+ T Cells.

scientific article published on 20 July 2016

Ovine TRIM5α can restrict visna/maedi virus.

scientific article

Phylogenetic analysis of murine leukemia virus sequences from longitudinally sampled chronic fatigue syndrome patients suggests PCR contamination rather than viral evolution.

scientific article

Positional cloning of the mouse retrovirus restriction gene Fv1.

scientific article published on August 1996

Positive Selection Analysis of Overlapping Reading Frames Is Invalid

scientific article published on 30 June 2015

Post-entry restriction of retroviral infections.

scientific article published on July 2003

Preventing the N-terminal processing of human interferon α-2b and its chimeric derivatives expressed in Escherichia coli.

scientific article

Restriction of lentivirus in monkeys

scientific article

Restriction of multiple divergent retroviruses by Lv1 and Ref1

scientific article published on February 2003

Retinoic acid inhibits both the basal activity and phorbol ester-mediated activation of the HIV long terminal repeat promoter.

scientific article published on February 1995

Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription.

scientific article published on March 2006

Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities

scientific article

SAMHD1-dependent retroviral control and escape in mice.

scientific article published on 19 July 2013

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

scientific article published on 17 December 2015

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

scientific article

Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M

scientific article published on 25 September 2013

The control of viral infection by tripartite motif proteins and cyclophilin A.

scientific article published on 12 June 2007

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

scientific article published on 29 November 2018

Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat

scientific article published on 03 June 2009

Ultra Structural Characterisation of Tetherin - a Protein Capable of Preventing Viral Release from the Plasma Membrane ⬇️

scientific article published on April 12, 2010

Upregulation of TRIM5α gene expression after live-attenuated simian immunodeficiency virus vaccination in Mauritian cynomolgus macaques, but TRIM5α genotype has no impact on virus acquisition or vaccination outcome

scientific article

Virulent poxviruses inhibit DNA sensing by preventing STING activation

scientific article published on 28 February 2018

Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.

scientific article

List of works by Gregory Towers

A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages

A model for cofactor use during HIV-1 reverse transcription and nuclear entry

Abrogation of Ref1 retrovirus restriction in human cells

Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation

An active TRIM5 protein in rabbits indicates a common antiviral ancestor for mammalian TRIM5 proteins.

Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection

Analysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin.

Anti-retroviral innate immune responses in multiple lymphoid tissues elicited by protective live attenuated SIV vaccination.

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

Characterization of murine leukemia virus restriction in mammals.

Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

Control of viral infectivity by tripartite motif proteins.

Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity.

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells

Cyclosporine increases human immunodeficiency virus type 1 vector transduction of primary mouse cells.

DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages

Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles

Disease-associated XMRV sequences are consistent with laboratory contamination

Diversity of TRIM5α and TRIMCyp sequences in cynomolgus macaques from different geographical origins.

Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues

Early potent protection against heterologous SIVsmE660 challenge following live attenuated SIV vaccination in Mauritian cynomolgus macaques.

Early presentation of HIV-1 KF11Gag and KK10Gag protective epitopes facilitate rapid CD8+ T cell activation and killing of virus infected cells.

Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation

Fusion of cyclophilin A to Fv1 enables cyclosporine-sensitive restriction of human and feline immunodeficiency viruses.

Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1.

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2

HIV, cyclophilins and nuclear entry: going under the radar.

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF- κB/IRF3 nuclear transport

HIV-1 evades innate immune recognition through specific cofactor recruitment

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

Hepatitis C virus exploits cyclophilin A to evade PKR

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

Identification of a RELIK orthologue in the European hare (Lepus europaeus) reveals a minimum age of 12 million years for the lagomorph lentiviruses

Identification of the regions of Fv1 necessary for murine leukemia virus restriction.

Identifying a nuclear passport for HIV

Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy

Inhibition of retroviral replication by members of the TRIM protein family.

Interactions between HIV-1 and the cell-autonomous innate immune system.

KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control

Lentiviral gene therapy against human immunodeficiency virus type 1, using a novel human TRIM21-cyclophilin A restriction factor.

MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface

No evidence of XMRV in prostate cancer cohorts in the Midwestern United States

Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8+ T Cells.

Ovine TRIM5α can restrict visna/maedi virus.

Phylogenetic analysis of murine leukemia virus sequences from longitudinally sampled chronic fatigue syndrome patients suggests PCR contamination rather than viral evolution.

Positional cloning of the mouse retrovirus restriction gene Fv1.

Positive Selection Analysis of Overlapping Reading Frames Is Invalid

Post-entry restriction of retroviral infections.

Preventing the N-terminal processing of human interferon α-2b and its chimeric derivatives expressed in Escherichia coli.

Restriction of lentivirus in monkeys

Restriction of multiple divergent retroviruses by Lv1 and Ref1

Retinoic acid inhibits both the basal activity and phorbol ester-mediated activation of the HIV long terminal repeat promoter.

Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription.

Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities

SAMHD1-dependent retroviral control and escape in mice.

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M

The control of viral infection by tripartite motif proteins and cyclophilin A.

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat

Ultra Structural Characterisation of Tetherin - a Protein Capable of Preventing Viral Release from the Plasma Membrane ⬇️

Upregulation of TRIM5α gene expression after live-attenuated simian immunodeficiency virus vaccination in Mauritian cynomolgus macaques, but TRIM5α genotype has no impact on virus acquisition or vaccination outcome

Virulent poxviruses inhibit DNA sensing by preventing STING activation

Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.