List of works - Pascale Moreau

A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia

scientific article published on 24 January 2019

Analogues of antifungal tjipanazoles from rebeccamycin.

scientific article published on April 2004

Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

scientific article

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

scientific article

Heteroaromatic Pim Kinase Inhibitors Containing a Pyrazole Moiety.

scientific article published on 19 May 2016

Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.

scientific article published on 26 February 2013

In-vitro antiproliferative activities and kinase inhibitory potencies of glycosyl-isoindigo derivatives.

scientific article published on October 2007

Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas.

scientific article published on 2 April 2012

Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives.

scientific article

New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities

scientific article published on 26 September 2014

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

scientific article published on 26 January 2019

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

scientific article

Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety

scientific article published in August 2003

Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.

scientific article

Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.

scientific article published on November 2003

Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.

scientific article

Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent

scientific article

Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells

scientific article published on 24 October 2015

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.

scientific article published on 5 December 2005

Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties

scientific article published on 03 May 2006

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.

scientific article

Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

scientific article

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

scientific article published on 12 May 2009

Synthesis and biological activities of new di- and trimeric quinoline derivatives.

scientific article published on 16 July 2010

Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives.

scientific article published on 15 September 2010

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

scientific article published on 18 May 2016

Synthesis and biological evaluation of oxindoles and benzimidazolinones derivatives.

scientific article published in May 2004

Synthesis and in vitro antiproliferative activities of quinoline derivatives.

scientific article

Synthesis and molecular modeling study of new trimeric quinoline derivatives

scientific article published on 14 July 2011

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives

scientific article published on 16 July 2016

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

scientific article

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.

scientific article published on 19 August 2010

Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7'-azaisoindigo derivatives substituted by Sonogashira cross-coupling.

scientific article published on 5 February 2009

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors

scientific article

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

scientific article published on 10 June 2011

Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site.

scientific article published in July 2001

List of works by Pascale Moreau

A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia

Analogues of antifungal tjipanazoles from rebeccamycin.

Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

Heteroaromatic Pim Kinase Inhibitors Containing a Pyrazole Moiety.

Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.

In-vitro antiproliferative activities and kinase inhibitory potencies of glycosyl-isoindigo derivatives.

Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas.

Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives.

New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety

Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.

Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.

Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.

Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent

Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.

Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.

Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

Synthesis and biological activities of new di- and trimeric quinoline derivatives.

Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives.

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

Synthesis and biological evaluation of oxindoles and benzimidazolinones derivatives.

Synthesis and in vitro antiproliferative activities of quinoline derivatives.

Synthesis and molecular modeling study of new trimeric quinoline derivatives

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.

Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7'-azaisoindigo derivatives substituted by Sonogashira cross-coupling.

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site.