List of works - Fabrice Anizon

A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia

scientific article published on 24 January 2019

A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor

scientific article published on 3 July 2008

Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

scientific article

Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.

scientific article

Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.

scientific article

DNA targeting of two new antitumour rebeccamycin derivatives.

scientific article published in December 2002

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

scientific article

Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue

scientific article published on 01 February 1999

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors

scientific article

Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.

scientific article

Heteroaromatic Pim Kinase Inhibitors Containing a Pyrazole Moiety.

scientific article published on 19 May 2016

Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors

scientific article published on 16 May 2013

Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.

scientific article published on 26 February 2013

In-vitro antiproliferative activities and kinase inhibitory potencies of glycosyl-isoindigo derivatives.

scientific article published on October 2007

In-vitro antiproliferative activities and kinase inhibitory potencies of meridianin derivatives

scientific article

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies

scientific article published on 04 April 2019

Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives.

scientific article

New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities

scientific article published on 26 September 2014

New potent and selective inhibitor of Pim-1/3 protein kinases sensitizes human colon carcinoma cells to doxorubicin

scientific article published on January 2014

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

scientific article published on 26 January 2019

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

scientific article

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

scientific article

Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety

scientific article published in August 2003

Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.

scientific article

Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.

scientific article published on November 2003

Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens

scientific article published in March 2002

Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.

scientific article

Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent

scientific article

Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle

scientific article published on May 1998

Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin

scientific article published on September 1998

Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells

scientific article published on 24 October 2015

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.

scientific article published on 5 December 2005

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.

scientific article

Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

scientific article

Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.

scientific article

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

scientific article published on 12 May 2009

Synthesis and biological activities of isogranulatimide analogues.

scientific article

Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.

scientific article published on 28 August 2007

Synthesis and biological activities of new di- and trimeric quinoline derivatives.

scientific article published on 16 July 2010

Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators

scientific article published on 17 September 2012

Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives.

scientific article published on 15 September 2010

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

scientific article published on 18 May 2016

Synthesis and biological evaluation of diversely substituted indolin-2-ones

scientific article published on 25 January 2008

Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions

scientific article published on 3 February 2006

Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework

scientific article

Synthesis and in vitro antiproliferative activities of quinoline derivatives.

scientific article

Synthesis and molecular modeling study of new trimeric quinoline derivatives

scientific article published on 14 July 2011

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives

scientific article published on 16 July 2016

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

scientific article

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.

scientific article published on 19 August 2010

Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.

scientific article

Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone.

scientific article published on 7 April 2007

Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7'-azaisoindigo derivatives substituted by Sonogashira cross-coupling.

scientific article published on 5 February 2009

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors

scientific article

Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives

scientific article

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

scientific article published on 10 June 2011

Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

scientific article

List of works by Fabrice Anizon

A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia

A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor

Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.

Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.

DNA targeting of two new antitumour rebeccamycin derivatives.

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors

Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.

Heteroaromatic Pim Kinase Inhibitors Containing a Pyrazole Moiety.

Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors

Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.

In-vitro antiproliferative activities and kinase inhibitory potencies of glycosyl-isoindigo derivatives.

In-vitro antiproliferative activities and kinase inhibitory potencies of meridianin derivatives

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies

Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives.

New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities

New potent and selective inhibitor of Pim-1/3 protein kinases sensitizes human colon carcinoma cells to doxorubicin

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety

Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.

Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.

Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens

Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.

Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent

Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle

Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin

Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.

Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

Synthesis and biological activities of isogranulatimide analogues.

Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.

Synthesis and biological activities of new di- and trimeric quinoline derivatives.

Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators

Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives.

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

Synthesis and biological evaluation of diversely substituted indolin-2-ones

Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions

Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework

Synthesis and in vitro antiproliferative activities of quinoline derivatives.

Synthesis and molecular modeling study of new trimeric quinoline derivatives

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.

Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.

Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone.

Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7'-azaisoindigo derivatives substituted by Sonogashira cross-coupling.

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors

Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors.