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List of works by Bruno Linclau

3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation

scientific article published on 29 May 2019

6'-derivatised alpha-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice

scientific article published in December 2008

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

scientific article published on 30 January 2019

A Study of Intramolecular Hydrogen Bonding in Levoglucosan Derivatives

scientific article published on 24 March 2017

A computational study of vicinal fluorination in 2,3-difluorobutane: implications for conformational control in alkane chains

scientific article published on 21 November 2014

A linear synthesis of gemcitabine.

scientific article

A novel stereoselective one-pot conversion of alcohols into alkyl halides mediated by N,N'-diisopropylcarbodiimide.

scientific article published in January 2003

A novel, versatile D-->BCD steroid construction strategy, illustrated by the enantioselective total synthesis of estrone.

scientific article published in February 2010

A practical synthesis of a high-loading solid-supported IBX amide for the oxidation of alcohols.

scientific article published in January 2005

An enantioselective desymmetrisation approach to C9-substituted trans-hydrindene rings based on a diastereotopic group-selective intramolecular Diels-Alder reaction

scientific article published on 05 October 2006

An unexpected and significantly lower hydrogen-bond-donating capacity of fluorohydrins compared to nonfluorinated alcohols.

scientific article published on 10 May 2012

Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates

scientific article published on 11 May 2020

Conformational influence of fluorinated building blocks on the physical properties of polyesters

Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer-Moest Reaction under Flow Conditions

scientific article published on 07 November 2019

Design of fluorinated 5-HT(4)R antagonists: influence of the basicity and lipophilicity toward the 5-HT(4)R binding affinities

scientific article published on 7 September 2013

Development of a Solid Phase Array Assay for the Screening of Galactose Oxidase Activity and for Fast Identification of Inhibitors.

scientific article published on 24 July 2017

Dietary Phytosterols Protective Against Peptic Ulceration

scientific article published on 20 July 2011

Divergent synthetic approach to 6''-modified α-GalCer analogues ⬇️

scientific article

Effects of sugar functional groups, hydrophobicity, and fluorination on carbohydrate-DNA stacking interactions in water.

scientific article

Efficient desymmetrization of "pseudo"-C2-symmetric substrates: illustration in the synthesis of a disubstituted butenolide from arabitol.

scientific article published in March 2003

Enantioselective Synthesis of Dideoxy-tetrafluorinated Hexoses

scientific article published on 06 April 2016

Enantioselective synthesis and selective monofunctionalization of (4R,6R)-4,6- dihydroxy-2,8-dioxabicyclo[3.3.0]octane

scientific article published on 01 December 2006

Enantioselective synthesis of tetrafluorinated glucose and galactose

scientific article published on 01 August 2008

Enzymatic glycosylation involving fluorinated carbohydrates

scientific article published on 22 April 2020

Exploring anomeric glycosylation of phosphoric acid: Optimisation and scope for non-native substrates

scientific article published on 19 December 2019

Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

scientific article published on 10 June 2020

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase

scientific article published on 13 September 2011

Influence of Alcohol β-Fluorination on Hydrogen-Bond Acidity of Conformationally Flexible Substrates

scientific article published in December 2016

Influence of Fluorination on the Conformational Properties and Hydrogen-Bond Acidity of Benzyl Alcohol Derivatives.

scientific article

Intramolecular OH⋅⋅⋅Fluorine Hydrogen Bonding in Saturated, Acyclic Fluorohydrins: The γ-Fluoropropanol Motif.

scientific article published on 23 October 2015

Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands

scientific article

Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method.

scientific article published on 23 November 2015

Isolation and characterisation of an unexpected byproduct in the regioselective butane diacetal protection of α-methyl galactopyranoside.

scientific article published on 6 November 2017

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups

scientific article published on 02 September 2020

Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas

scientific article published on 01 August 2002

Minimising conformational bias in fluoroprolines through vicinal difluorination

scientific article published on 2 May 2018

Molecular Insights into DC-SIGN Binding to Self-Antigens: The Interaction with the Blood Group A/B Antigens

scientific article published on 08 July 2019

Plant cell wall imaging by metabolic click-mediated labelling of rhamnogalacturonan II using azido 3-deoxy-D-manno-oct-2-ulosonic acid.

scientific article published in February 2016

Polymer-supported O-methylisourea: a new reagent for the O-methylation of carboxylic acids

scientific article published on 01 March 2002

Polymer-supported o-benzyl and o-allylisoureas: convenient preparation and use in ester synthesis from carboxylic acids

scientific article published on 01 March 2003

Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides

scientific article published on 30 June 2020

Rapid Screening of Diverse Biotransformations for Enzyme Evolution

scientific article published on 26 April 2021

Ready synthetic access to enantiopure allylic α(F)-branched fluoroalkenes

scientific article published on 08 May 2013

Reducing the lipophilicity of perfluoroalkyl groups by CF2-F/CF2-Me or CF3/CH3 exchange

scientific article published on 28 November 2018

Short synthesis of enantiopure C2-symmetric 1,2:4,5-diepoxypentane and "pseudo"-C2-symmetric 3-azido-1,2:4,5-diepoxypentane from arabitol.

scientific article published in October 2003

Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs

scientific article published on 05 January 2021

Stereoarrays with an all-carbon quaternary center: diastereoselective desymmetrization of prochiral malonaldehydes

scientific article published on 23 December 2011

Stereocontrol by quaternary centres: a stereoselective synthesis of (-)-luminacin D.

scientific article published on 12 February 2014

Stereoselectivity of the Honda–Reformatsky Reaction in Reactions with Ethyl Bromodifluoroacetate with α-Oxygenated Sulfinylimines

scientific article published on 18 April 2014

Structural basis of ligand binding to UDP-galactopyranose mutase from Mycobacterium tuberculosis using substrate and tetrafluorinated substrate analogues

scientific article

Synthesis and Conformational Properties of 3,4-Difluoro-l-prolines

scientific article published on 27 February 2019

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

scientific article published in 2008

Synthesis and crystallographic analysis of meso-2,3-difluoro-1,4-butanediol and meso-1,4-dibenzyloxy-2,3-difluorobutane.

scientific article published on 8 June 2010

Synthesis and evaluation of amino-modified alpha-GalCer analogues

scientific article published on July 2010

Synthesis and in vitro evaluation of alpha-GalCer epimers

scientific article published in July 2008

Synthesis and screening of a library of Lewis deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

scientific article published on 13 September 2024

Synthesis of 2,3,4-Trideoxy-2,3,4-trifluoroglucose

scientific article published on 28 March 2019

Synthesis of vicinal dideoxy-difluorinated galactoses

scientific article published on 01 May 2019

Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs

scientific article published on 17 January 2020

Tetrafluorination of sugars as strategy for enhancing protein-carbohydrate affinity: application to UDP-Galp mutase inhibition.

scientific article published on 5 December 2013

The conformation of tetrafluorinated methyl galactoside anomers: crystallographic and NMR studies

scientific article published on 08 April 2011

The development of a short route to the API ropinirole hydrochloride.

scientific article published on 4 September 2015

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.

scientific article

The synthesis of gemcitabine

scientific article

The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers

scientific article published on 27 December 2017

Total Synthesis of (-)-Luminacin D

scientific article published on 19 April 2016

Total Synthesis of (±)-Paroxetine by Diastereoconvergent Cobalt-Catalysed Arylation

scientific article published on 27 May 2014

Transmembrane Exchange of Fluorosugars: Characterization of Red Cell GLUT1 Kinetics Using F NMR

scientific article published on 05 October 2018

Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates

scientific article published on 25 June 2019

α-Fluoro-o-cresols: The Key Role of Intramolecular Hydrogen Bonding in Conformational Preference and Hydrogen-Bond Acidity

scientific article published on 30 May 2016

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