List of works by Luc J.W. van der Laan

A Comparison of Free Radical-Induced Vascular and Skeletal Muscle Damage in Immunocompetent and Neutropenic Rats

scientific article published on 01 April 1999

A Novel Animal Model to Evaluate Oxygen Derived Free Radical Damage in Soft Tissue

article

A dynamic perspective of RNAi library development.

scientific article

AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application?

scientific article published on 05 January 2011

Action and Function of Vitamin D in Digestive Tract Physiology and Pathology.

scientific article published on 28 December 2016

Advancement of Mesenchymal Stem Cell Therapy in Solid Organ Transplantation (MISOT)

article

Allosuppressive donor CD4+CD25+ regulatory T cells detach from the graft and circulate in recipients after liver transplantation

article

Antiviral or proviral action of mycophenolic acid in hepatitis B infection?

scientific article published on 01 October 2012

Association of circulating microRNA-122 and microRNA-29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers

scientific article published on 11 December 2018

Barking up the wrong tree: MicroRNAs in bile as markers for biliary complications

scientific article published on 01 June 2014

Beneficial effect of modified peptide inhibitor of alpha4 integrins on experimental allergic encephalomyelitis in Lewis rats.

scientific article published on January 2002

Bioengineering Liver Transplantation

scientific article published on 16 October 2019

Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation.

scientific article published on 04 May 2014

CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells ⬇️

scientific article published on July 1, 1992

CMV Primary Infection Is Associated With Donor-Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation.

scientific article published on 5 May 2015

Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus

scientific article published on 26 February 2014

Canine hepacivirus and idiopathic hepatitis in dogs from a Dutch cohort

scientific article published on 5 June 2014

Cell-free MicroRNA miR-505-3p in Graft Preservation Fluid Is an Independent Predictor of Delayed Graft Function After Kidney Transplantation

scientific article published on 01 February 2019

Cell-free microRNAs as early predictors of graft viability during ex vivo normothermic machine perfusion of human donor livers

scientific article published on 20 February 2020

Cellular and Molecular Mechanisms of Mesenchymal Stem Cell Actions.

scientific article

Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow

scientific article published on 14 October 2015

Characterization of Antigen-Presenting Cell Subsets in Human Liver-Draining Lymph Nodes

scientific article published on 14 March 2019

Characterization of donor and recipient CD8+ tissue-resident memory T cells in transplant nephrectomies

scientific article published on 12 April 2019

Characterization of rabbit antithymocyte globulins-induced CD25+ regulatory T cells from cells of patients with end-stage renal disease

scientific article published on 01 March 2010

Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C without affecting vector delivery and gene silencing

scientific article (publication date: July 2009)

Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV.

scientific article

Corrigendum to "MicroRNA profiles in graft preservation solution are predictive of ischemic-type biliary lesions after liver transplantation" [J Hepatol 2013; 59:1231-1238].

scientific article

Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction

scientific article

Cross Talk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication

scientific article published on 29 February 2016

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

article

Culture expansion induces non-tumorigenic aneuploidy in adipose tissue-derived mesenchymal stromal cells.

scientific article published in November 2013

Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen

scientific article published on 13 July 2015

Decellularization of Whole Human Liver Grafts Using Controlled Perfusion for Transplantable Organ Bioscaffolds.

scientific article

Decrease of CD4+CD25+ T cells in peripheral blood after liver transplantation: association with immunosuppression.

scientific article published in March 2005

Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay

scientific article

Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells.

scientific article published on 13 November 2013

Dexamethasone transforms lipopolysaccharide-stimulated human blood myeloid dendritic cells into myeloid dendritic cells that prime interleukin-10 production in T cells

scientific article published on 27 February 2008

Differential Sensitivities of Fast- and Slow-cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by Mycophenolic Acid.

scientific article published on 13 October 2015

Differential effects of anti-rat CD11b monoclonal antibodies on granulocyte adhesiveness

scientific article published on 01 January 1999

Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett's oesophagus.

scientific article published on January 2011

Digestive disease week 2011: highlights of clinical and preclinical research on Barrett's esophagus and associated esophageal adenocarcinoma.

scientific article published on 27 March 2012

Disparity of basal and therapeutically activated interferon signalling in constraining hepatitis E virus infection

scientific article published on December 2015

Distinct Antiviral Potency of Sofosbuvir Against Hepatitis C and E Viruses.

scientific article published in November 2016

Donor and recipient HLA/KIR genotypes do not predict liver transplantation outcome

scientific article published on 14 June 2011

Donor-specific anti-HLA antibodies are not associated with nonanastomotic biliary strictures but both are independent risk factors for graft loss after liver transplantation.

scientific article published on 29 November 2017

Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury

scientific article published on 14 July 2017

Evidence of B-cell follicles with germinal centers in chronic hepatitis C patients.

scientific article published on 12 March 2015

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells.

scientific article published on 22 July 2013

Experimental models to unravel the molecular pathogenesis, cell of origin and stem cell properties of cholangiocarcinoma

scientific article published on 01 May 2019

Fast, robust and effective decellularization of whole human livers using mild detergents and pressure controlled perfusion

scientific article published on 12 September 2019

First Report on Ex Vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion

scientific article published on 01 January 2020

Flow cytometry of fine-needle-aspiration biopsies: a new method to monitor the intrahepatic immunological environment in chronic viral hepatitis

scientific article published on 01 September 2005

Flowcytometric quantitation of hepatitis B viral antigens in hepatocytes from regular and fine-needle biopsies

scientific article published on 27 February 2007

From organoids to organs: Bioengineering liver grafts from hepatic stem cells and matrix

scientific article

Gene therapies for hepatitis C virus.

scientific article

Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney disease after liver transplantation

article

Growth factors G-CSF and GM-CSF differentially preserve chemotaxis of neutrophils aging in vitro.

scientific article published in April 2007

Hepatitis virus hijacks shuttle: exosome-like vesicles provide protection against neutralizing antibodies.

scientific article published on 14 April 2014

Hepatocyte-derived microRNAs as sensitive serum biomarkers of hepatocellular injury in Labrador retrievers.

scientific article

Human Bile Contains Cholangiocyte Organoid-Initiating Cells Which Expand as Functional Cholangiocytes in Non-canonical Wnt Stimulating Conditions

publication published on 01 January 2020

Human graft-derived mesenchymal stromal cells potently suppress alloreactive T-cell responses

scientific article published on 28 April 2015

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

scientific article published on 13 November 2017

IL-21 Receptor Antagonist Inhibits Differentiation of B Cells toward Plasmablasts upon Alloantigen Stimulation

scientific article published on 20 March 2017

Identification and Validation Model for Informative Liquid Biopsy-Based microRNA Biomarkers: Insights from Germ Cell Tumor In Vitro, In Vivo and Patient-Derived Data

scientific article published on 14 December 2019

Impact of immunosuppressive drugs on CD4+CD25+FOXP3+ regulatory T cells: does in vitro evidence translate to the clinical setting?

scientific article published on March 2008

Impact of steroids on hepatitis C virus replication in vivo and in vitro.

scientific article published in September 2007

Improving Accuracy of Urinary miRNA Quantification in Heparinized Patients Using Heparinase I Digestion.

scientific article published on 3 September 2016

Inflammatory genes in rat livers from cardiac- and brain death donors

scientific article

Interaction of immunosuppressants with HCV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid

scientific article published on 01 September 2018

Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsy.

scientific article published in March 2007

Intravenous immunoglobulin treatment in humans suppresses dendritic cell function via stimulation of IL-4 and IL-13 production.

scientific article published on 7 May 2014

JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa.

scientific article

Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function.

scientific article published on 31 October 2014

LGR5 marks targetable tumor-initiating cells in mouse liver cancer

scientific article published on 23 April 2020

Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells

scientific article published on 12 November 2019

Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells.

scientific article published on 6 March 2017

Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation

scientific article published on 01 July 2010

Long-term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesis

scientific article published on 24 February 2021

Low circulating regulatory T-cell levels after acute rejection in liver transplantation.

scientific article published in February 2006

Macrophage scavenger receptor MARCO: In vitro and in vivo regulation and involvement in the anti-bacterial host defense ⬇️

scientific article published on June 1, 1997

Mesenchymal Stromal Cell-Derived Factors Promote Tissue Repair in a Small-for-Size Ischemic Liver Model but Do Not Protect against Early Effects of Ischemia and Reperfusion Injury.

scientific article

MicroRNA profiles in graft preservation solution are predictive of ischemic-type biliary lesions after liver transplantation.

scientific article

MicroRNAs in bile vesicles: finding a trade-off for biomarker discovery.

scientific article

Migration of allosensitizing donor myeloid dendritic cells into recipients after liver transplantation

scientific article published on 01 January 2010

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth

scientific article published on 04 January 2020

Mobilization of hepatic mesenchymal stem cells from human liver grafts

scientific article published on 01 May 2011

Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors

scientific article published on 01 March 2019

Mycophenolic acid inhibits hepatitis C virus replication and acts in synergy with cyclosporin A and interferon-alpha.

scientific article published on 14 August 2006

NADH videofluorimetry to monitor the energy state of skeletal muscle in vivo

scientific article published on 01 February 1998

NK cells can generate from precursors in the adult human liver.

scientific article

Necroptotic Cell Death in Liver Transplantation and Underlying Diseases: Mechanisms and Clinical Perspective

scientific article published on 01 July 2019

New targets for treatment against HCV infection.

scientific article published on August 2012

New therapeutic opportunities for hepatitis C based on small RNA.

scientific article published on September 2007

No association between tumor necrosis factor-alpha production and gene polymorphisms among inbred rat strains

scientific article published on 01 June 2005

No evidence for circulating mesenchymal stem cells in patients with organ injury.

scientific article published on 25 August 2014

Overestimation of hematopoietic stem cell frequencies in human liver grafts

scientific article published on 08 April 2013

Polarized release of hepatic microRNAs into bile and serum in response to cellular injury and impaired liver function.

scientific article

Posttransplant management of recipients undergoing liver transplantation for hepatocellular carcinoma. Working Group Report from the ILTS Transplant Oncology Consensus Conference

scientific article published on 23 March 2020

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

scientific article published on 18 November 2021

Prednisolone does not affect direct-acting antivirals against hepatitis C, but inhibits interferon-alpha production by plasmacytoid dendritic cells.

scientific article published on 7 August 2015

Prime editing for functional repair in patient-derived disease models

scientific article published on 23 October 2020

Production of multicopy shRNA lentiviral vectors for antiviral therapy.

scientific article

Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice: an immunohistochemical study

scientific article published on 01 March 1999

Prominent HLA-G Expression in Liver Disease But Not After Liver Transplantation.

scientific article published on 8 May 2015

Prospects of RNAi and microRNA-based therapies for hepatitis C.

scientific article published on June 2009

Protocol for the STRONG trial: stereotactic body radiation therapy following chemotherapy for unresectable perihilar cholangiocarcinoma, a phase I feasibility study

scientific article published on 15 October 2018

RIG-I is a key antiviral interferon-stimulated gene against hepatitis E virus regardless of interferon production.

scientific article published on 13 February 2017

Recreating Tumour Complexity in a Dish: Organoid Models to Study Liver Cancer Cells and their Extracellular Environment

scientific article published on 01 November 2019

Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection.

scientific article published in April 2005

Relationship between the histological appearance of the portal vein and development of ischemic-type biliary lesions after liver transplantation

scientific article published on 13 August 2013

Reply to "Detection and Analysis of Circulating Epithelial Cells in Liquid Biopsies from Patients with Liver Disease": Implications for Transplant Chimerism

scientific article published on 13 February 2019

Ribavirin enhances interferon-stimulated gene transcription by activation of the interferon-stimulated response element.

scientific article published in April 2011

Rotterdam: main port for organ transplantation research in the Netherlands

scientific article published on 18 September 2014

Secreted factors of human liver-derived mesenchymal stem cells promote liver regeneration early after partial hepatectomy.

scientific article

Simultaneous targeting of HCV replication and viral binding with a single lentiviral vector containing multiple RNA interference expression cassettes.

scientific article published on 26 July 2006

Support of hepatic regeneration by trophic factors from liver-derived mesenchymal stromal/stem cells

scientific article published on 01 January 2014

T Follicular Helper Cells As a New Target for Immunosuppressive Therapies.

scientific article published on 7 November 2017

The Effects of an IL-21 Receptor Antagonist on the Alloimmune Response in a Humanized Mouse Skin Transplant Model

scientific article published on 01 October 2019

The Jak inhibitor CP-690,550 preserves the function of CD4CD25FoxP3 regulatory T cells and inhibits effector T cells

scientific article published on 12 July 2010

The calcineurin inhibitor tacrolimus allows the induction of functional CD4CD25 regulatory T cells by rabbit anti-thymocyte globulins.

scientific article published on 28 May 2010

The effect of rabbit anti-thymocyte globulin induction therapy on regulatory T cells in kidney transplant patients.

scientific article published on 28 January 2009

The ins and outs of microRNAs as biomarkers in liver disease and transplantation.

scientific article published on 29 September 2014

The macrophage receptor MARCO.

scientific article

The release of microRNA-122 during liver preservation is associated with early allograft dysfunction and graft survival after transplantation

scientific article

The role of the mouse macrophage scavenger receptor in myelin phagocytosis

scientific article published on 01 December 1997

Tumor microRNA-126 controls cell viability and associates with poor survival in patients with esophageal adenocarcinoma

scientific article published on 07 August 2019

Tumor promotion through the mesenchymal stem cell compartment in human hepatocellular carcinoma.

scientific article published on 5 June 2013

Ultra-thin fluorocarbon foils optimise multiscale imaging of three-dimensional native and optically cleared specimens

scientific article published on 21 November 2019

Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections.

scientific article published on 25 April 2017

Use of Serum MicroRNAs as Biomarker for Hepatobiliary Diseases in Dogs.

scientific article

Virus-drug interactions--molecular insight into immunosuppression and HCV.

scientific article published on 17 April 2012

Vitamin D Receptor Polymorphisms Are Associated with Reduced Esophageal Vitamin D Receptor Expression and Reduced Esophageal Adenocarcinoma Risk.

scientific article

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