List of works - Yesim Dargaud

A case of Glanzmann's thrombasthenia successfully treated with recombinant factor viia during a surgical procedure: observations on the monitoring and the mechanism of action of this drug

scientific article published on 01 June 2006

A new paradigm for personalized prophylaxis for patients with severe haemophilia A

scientific article published on 26 February 2020

A risk score for the management of pregnant women with increased risk of venous thromboembolism: a multicentre prospective study

scientific article

Achievements, challenges and unmet needs for haemophilia patients with inhibitors: Report from a symposium in Paris, France on 20 November 2014.

scientific article published on January 2016

Acquired Glanzmann's thrombasthenia associated with acute lymphoblastic leukemia.

scientific article published in October 2005

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.

scientific article published on 13 April 2015

An unusual clinical presentation of factor XIII deficiency and issues relating to the monitoring of factor XIII replacement therapy

scientific article published on 01 July 2008

Basic aspects of bypassing agents.

scientific article published on December 2006

Bleeding risk in warfarinized patients with a therapeutic international normalized ratio: the effect of low factor IX levels.

scientific article published in June 2013

Case scenario: management of trauma-induced coagulopathy in a severe blunt trauma patient.

scientific article

Challenges of the management of severe hemophilia A with inhibitors: two case reports emphasizing the potential interest of a high-purity human Factor VIII/von Willebrand factor concentrate and individually tailored prophylaxis guided by thrombin-ge

scientific article

Characterisation of 96 mutations in 128 unrelated severe haemophilia A patients from France. Description of 62 novel mutations

scientific article published on 01 April 2006

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

scientific article

Combined life-threatening thromboses and hemorrhages in a patient with afibrinogenemia and antithrombin deficiency

scientific article published on 4 April 2018

Comparison of current platelet functional tests for the assessment of aspirin and clopidogrel response. A review of the literature.

scientific article

Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study.

scientific article published on 27 March 2008

Delayed-type hypersensitivity to heparin: diagnosis and therapeutic management

scientific article

Diagnosis and management challenges in patients with mild haemophilia A and discrepant FVIII measurements

scientific article published on 12 February 2014

Do heterozygous factor V Leiden and prothrombin G20210A mutations have different impact on the type and location of venous thromboembolism?

scientific article published in August 2014

Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C>A mutation.

scientific article

Effect of standardization and normalization on imprecision of calibrated automated thrombography: an international multicentre study.

scientific article published on October 2007

Elimination of contact factor activation improves measurement of platelet-dependent thrombin generation by calibrated automated thrombography at low-concentration tissue factor

scientific article published on 01 May 2006

Endogenous thrombin potential, prothrombin fragment 1+2 and D-dimers during pregnancy

scientific article published on 18 December 2009

Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre study

scientific article

Evaluation of the overall haemostatic effect of recombinant factor VIIa by measuring thrombin generation and stability of fibrin clots.

scientific article published in April 2011

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

scientific article published in March 2005

Expression and characterization of a novel human recombinant factor IX molecule with enhanced in vitro and in vivo clotting activity.

scientific article

Feasibility of an easy-to-use risk score in the prevention of venous thromboembolism and placental vascular complications in pregnant women. A rebuttal

scientific article published on 01 January 2008

Genotyping might help therapeutic decision-making in patients with von Willebrand disease type 2 B.

scientific article published on 28 June 2016

Global haemostasis and point of care testing.

scientific article

Haemophilia patients exhibit prolonged coagulation time but normal lag time of thrombin generation test: are these results really discordant?

scientific article

Hemostatic effect of tranexamic acid combined with factor VIII concentrate in prophylactic setting in severe hemophilia A: A preclinical study

scientific article published on 22 December 2019

Hypofibrinolytic state and high thrombin generation may play a major role in sars-cov2 associated thrombosis

scientific article published on 15 July 2020

In vivo efficacy of human recombinant factor IX produced by the human hepatoma cell line HuH-7.

scientific article published on 15 May 2015

Individual thrombin generation and spontaneous bleeding rate during personalized prophylaxis with Nuwiq® (human-cl rhFVIII) in previously treated patients with severe haemophilia A

scientific article published on 31 May 2018

Individualized PK-based prophylaxis in severe haemophilia

scientific article published on 01 March 2018

Inherited bleeding disorder due to familial type 2 platelet cyclo-oxygenase deficiency

scientific article (publication date: 2005)

Intraindividual thrombin generation measurement variability in healthy adults over a one year period

scientific article published on 24 September 2008

Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decision.

scientific article

Management of pregnant women with increased risk of venous thrombosis

scientific article published on 01 September 2005

Monitoring platelet dependent thrombin generation in mice

scientific article published on 16 September 2010

Multiple arterial thromboses in a patient with primary antiphospholipid syndrome receiving a bromocriptine therapy.

scientific article published in January 2004

New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors.

scientific article published on July 2008

New developments in laboratory diagnosis and monitoring.

scientific article published on July 2010

On-demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII.

scientific article published on 19 July 2011

Personalized thromboprophylaxis using a risk score for the management of pregnancies with high risk of thrombosis: a prospective clinical study.

scientific article published on 23 February 2017

Pre-analytical effects of pneumatic tube system transport on routine haematology and coagulation tests, global coagulation assays and platelet function assays

scientific article published on 28 December 2016

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH.

scientific article published on 26 May 2017

Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery.

scientific article published in September 2010

Response to "Studies on hemostasis in COVID-19 deserve careful reporting of the laboratory methods, their significance and their limitation": don't throw the baby out with the bathwater

scientific article published on 28 August 2020

Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation?

scientific article published on 24 August 2020

Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCC.

scientific article

Spontaneous proximal deep vein thrombosis in a patient with severe haemophilia A.

scientific article published in June 2003

Standardisation of thrombin generation test--which reference plasma for TGT? An international multicentre study.

scientific article

Successive bleeding and thrombotic complications in a patient with afibrinogenemia: a case report

scientific article published on 14 April 2011

Tests of global haemostasis and their applications in bleeding disorders.

scientific article published on July 2010

The second Team Haemophilia Education Meeting, 2016, Frankfurt, Germany

scientific article published in January 2017

Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives.

scientific article published on 14 January 2013

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A ⬇️

scientific article published on August 1, 2011

Thrombin-generating capacity in patients with von Willebrand's disease

scientific article published on 01 December 2007

Use of calibrated automated thrombinography +/- thrombomodulin to recognise the prothrombotic phenotype

scientific article published on 01 November 2006

Use of the thrombin generation test to evaluate response to treatment with recombinant activated factor VII.

scientific article

Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab.

scientific article published on 22 February 2018

Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay.

scientific article

Why patients with THBD c.1611C>A (p.Cys537X) nonsense mutation have high levels of soluble thrombomodulin?

scientific article published on 16 November 2017

[Acquired factor V deficiency: a rare bleeding disorder with variable clinical presentations]

scientific article published on 17 July 2010

List of works by Yesim Dargaud

A case of Glanzmann's thrombasthenia successfully treated with recombinant factor viia during a surgical procedure: observations on the monitoring and the mechanism of action of this drug

A new paradigm for personalized prophylaxis for patients with severe haemophilia A

A risk score for the management of pregnant women with increased risk of venous thromboembolism: a multicentre prospective study

Achievements, challenges and unmet needs for haemophilia patients with inhibitors: Report from a symposium in Paris, France on 20 November 2014.

Acquired Glanzmann's thrombasthenia associated with acute lymphoblastic leukemia.

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.

An unusual clinical presentation of factor XIII deficiency and issues relating to the monitoring of factor XIII replacement therapy

Basic aspects of bypassing agents.

Bleeding risk in warfarinized patients with a therapeutic international normalized ratio: the effect of low factor IX levels.

Case scenario: management of trauma-induced coagulopathy in a severe blunt trauma patient.

Challenges of the management of severe hemophilia A with inhibitors: two case reports emphasizing the potential interest of a high-purity human Factor VIII/von Willebrand factor concentrate and individually tailored prophylaxis guided by thrombin-ge

Characterisation of 96 mutations in 128 unrelated severe haemophilia A patients from France. Description of 62 novel mutations

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

Combined life-threatening thromboses and hemorrhages in a patient with afibrinogenemia and antithrombin deficiency

Comparison of current platelet functional tests for the assessment of aspirin and clopidogrel response. A review of the literature.

Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study.

Delayed-type hypersensitivity to heparin: diagnosis and therapeutic management

Diagnosis and management challenges in patients with mild haemophilia A and discrepant FVIII measurements

Do heterozygous factor V Leiden and prothrombin G20210A mutations have different impact on the type and location of venous thromboembolism?

Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C>A mutation.

Effect of standardization and normalization on imprecision of calibrated automated thrombography: an international multicentre study.

Elimination of contact factor activation improves measurement of platelet-dependent thrombin generation by calibrated automated thrombography at low-concentration tissue factor

Endogenous thrombin potential, prothrombin fragment 1+2 and D-dimers during pregnancy

Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre study

Evaluation of the overall haemostatic effect of recombinant factor VIIa by measuring thrombin generation and stability of fibrin clots.

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

Expression and characterization of a novel human recombinant factor IX molecule with enhanced in vitro and in vivo clotting activity.

Feasibility of an easy-to-use risk score in the prevention of venous thromboembolism and placental vascular complications in pregnant women. A rebuttal

Genotyping might help therapeutic decision-making in patients with von Willebrand disease type 2 B.

Global haemostasis and point of care testing.

Haemophilia patients exhibit prolonged coagulation time but normal lag time of thrombin generation test: are these results really discordant?

Hemostatic effect of tranexamic acid combined with factor VIII concentrate in prophylactic setting in severe hemophilia A: A preclinical study

Hypofibrinolytic state and high thrombin generation may play a major role in sars-cov2 associated thrombosis

In vivo efficacy of human recombinant factor IX produced by the human hepatoma cell line HuH-7.

Individual thrombin generation and spontaneous bleeding rate during personalized prophylaxis with Nuwiq® (human-cl rhFVIII) in previously treated patients with severe haemophilia A

Individualized PK-based prophylaxis in severe haemophilia

Inherited bleeding disorder due to familial type 2 platelet cyclo-oxygenase deficiency

Intraindividual thrombin generation measurement variability in healthy adults over a one year period

Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decision.

Management of pregnant women with increased risk of venous thrombosis

Monitoring platelet dependent thrombin generation in mice

Multiple arterial thromboses in a patient with primary antiphospholipid syndrome receiving a bromocriptine therapy.

New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors.

New developments in laboratory diagnosis and monitoring.

On-demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII.

Personalized thromboprophylaxis using a risk score for the management of pregnancies with high risk of thrombosis: a prospective clinical study.

Pre-analytical effects of pneumatic tube system transport on routine haematology and coagulation tests, global coagulation assays and platelet function assays

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH.

Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery.

Response to "Studies on hemostasis in COVID-19 deserve careful reporting of the laboratory methods, their significance and their limitation": don't throw the baby out with the bathwater

Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation?

Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCC.

Spontaneous proximal deep vein thrombosis in a patient with severe haemophilia A.

Standardisation of thrombin generation test--which reference plasma for TGT? An international multicentre study.

Successive bleeding and thrombotic complications in a patient with afibrinogenemia: a case report

Tests of global haemostasis and their applications in bleeding disorders.

The second Team Haemophilia Education Meeting, 2016, Frankfurt, Germany

Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives.

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A ⬇️

Thrombin-generating capacity in patients with von Willebrand's disease

Use of calibrated automated thrombinography +/- thrombomodulin to recognise the prothrombotic phenotype

Use of the thrombin generation test to evaluate response to treatment with recombinant activated factor VII.

Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab.

Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay.

Why patients with THBD c.1611C>A (p.Cys537X) nonsense mutation have high levels of soluble thrombomodulin?

[Acquired factor V deficiency: a rare bleeding disorder with variable clinical presentations]