List of works - Markus M Forsberg

2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors

scientific article

4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.

scientific article published in July 2002

Absorption rate limit considerations for oral phosphate prodrugs

scientific article

An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors

scientific article published on 17 August 2006

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

scientific article

Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma

scientific article

Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.

scientific article published on 28 July 2011

Brain uptake of ketoprofen-lysine prodrug in rats

scientific article published on 19 August 2010

Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease.

scientific article published on 10 May 2017

Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats

scientific article

Comparison of in vitro cell models in predicting in vivo brain entry of drugs.

scientific article published on 8 October 2010

Comparison of phencyclidine-induced spatial learning and memory deficits and reversal by sertindole and risperidone between Lister Hooded and Wistar rats.

scientific article

Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat.

scientific article

Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats.

scientific article published on 25 October 2007

Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors.

scientific article published in August 2003

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.

scientific article published in October 2013

Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.

scientific article published in July 2005

Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.

scientific article published in September 2002

Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase

scientific article published on 17 July 2018

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.

scientific article published on 26 September 2017

Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat.

scientific article published on 22 March 2017

Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metabolism in anaesthetised rats

scientific article published in August 2001

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.

scientific article published on 3 September 2016

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity.

scientific article published on February 2016

Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum ⬇️

scientific article published on July 29, 2011

KYP-2047 penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase

scientific article published on 25 January 2014

Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice.

scientific article published on 17 September 2004

New Prolyl Oligopeptidase Inhibitors Developed from Dicarboxylic Acid Bis(l-prolyl-pyrrolidine) Amides ⬇️

scientific article published on October 9, 2003

Pharmacodynamic response of entacapone in rats after administration of entacapone formulations and prodrugs with varying bioavailabilities.

scientific article published in June 2002

Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells

scientific article published on 10 April 2011

Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex.

scientific article published on 23 July 2014

Quantitation of entacapone glucuronide in rat plasma by on-line coupled restricted access media column and liquid chromatography-tandem mass spectrometry

scientific article

Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells

scientific article published on 7 August 2013

Similar molecular descriptors determine the in vitro drug permeability in endothelial and epithelial cells.

scientific article

Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum

scientific article

Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease

scientific article published on 01 January 2019

Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.

scientific article published in August 2002

Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone

scientific article published on 01 January 2000

Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs.

scientific article published in November 2001

The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum.

scientific article

Unpredictable rotational responses to L-dopa in the rat model of Parkinson's disease: the role of L-dopa pharmacokinetics and striatal dopamine depletion.

scientific article published on 13 September 2011

List of works by Markus M Forsberg

2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors

4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.

Absorption rate limit considerations for oral phosphate prodrugs

An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma

Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.

Brain uptake of ketoprofen-lysine prodrug in rats

Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease.

Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats

Comparison of in vitro cell models in predicting in vivo brain entry of drugs.

Comparison of phencyclidine-induced spatial learning and memory deficits and reversal by sertindole and risperidone between Lister Hooded and Wistar rats.

Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat.

Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats.

Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors.

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.

Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.

Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.

Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.

Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat.

Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metabolism in anaesthetised rats

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity.

Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum ⬇️

KYP-2047 penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase

Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice.

New Prolyl Oligopeptidase Inhibitors Developed from Dicarboxylic Acid Bis(l-prolyl-pyrrolidine) Amides ⬇️

Pharmacodynamic response of entacapone in rats after administration of entacapone formulations and prodrugs with varying bioavailabilities.

Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells

Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex.

Quantitation of entacapone glucuronide in rat plasma by on-line coupled restricted access media column and liquid chromatography-tandem mass spectrometry

Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells

Similar molecular descriptors determine the in vitro drug permeability in endothelial and epithelial cells.

Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum

Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease

Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.

Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone

Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs.

The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum.

Unpredictable rotational responses to L-dopa in the rat model of Parkinson's disease: the role of L-dopa pharmacokinetics and striatal dopamine depletion.