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List of works by Rosalinde Masereeuw

A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition

scientific article

A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity.

scientific article published on 28 January 2016

A Randomized Trial of Distal Diuretics versus Dietary Sodium Restriction for Hypertension in Chronic Kidney Disease

scientific article published on 29 January 2020

A bioartificial kidney device with polarized secretion of immune modulators

scientific article published on 17 June 2018

A combined microphysiological-computational omics approach in dietary protein evaluation

scientific article published on 17 December 2020

A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue.

scientific article published on 18 February 2014

A proteome comparison between human fetal and mature renal extracellular matrix identifies EMILIN1 as a regulator of renal epithelial cell adhesion

scientific article published on 25 July 2019

ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney.

scientific article

Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis.

scientific article

Adding the T to ADME: Predictive Toxicity in Renal Drug Development

scientific article published on 05 September 2018

Advances in predictive in vitro models of drug-induced nephrotoxicity

scientific article published on 6 April 2018

Alkaline Phosphatase as a Treatment of Sepsis-Associated Acute Kidney Injury ⬇️

scientific article published on November 6, 2012

Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate.

scientific article

Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.

scientific article

Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients

scientific article published on 22 January 2014

Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application.

scientific article published on 2 August 2017

Altered tryptophan metabolism and CKD-associated fatigue

scientific article published on 01 November 2014

An introduction to the pharmacology of kidney regeneration

scientific article published on 30 June 2016

Anionic and cationic drug secretion in the isolated perfused rat kidney after neonatal surgical induction of ureteric obstruction.

scientific article published in September 2003

Application of urine proteomics for biomarker discovery in drug-induced liver injury.

scientific article published on 29 September 2014

Are cell-based therapies for kidney disease safe? A systematic review of preclinical evidence

scientific article published on 22 January 2019

Basolateral transport of the uraemic toxin p-cresyl sulfate: role for organic anion transporters?

scientific article published on 24 October 2011

Bioengineered bile ducts recapitulate key cholangiocyte functions

scientific article published on 12 June 2018

Bioengineered kidney tubules efficiently excrete uremic toxins.

scientific article published on 31 May 2016

Bioengineering Organs for Blood Detoxification

scientific article published on 19 September 2018

Biotechnological challenges of bioartificial kidney engineering.

scientific article

Can sulfasalazine therapy induce or exacerbate Wegener's granulomatosis?

scientific article

Carbon Nanotube Reinforced Supramolecular Hydrogels for Bioapplications

scientific article published on 07 August 2018

Cardiac Hepcidin Expression Associates with Injury Independent of Iron.

scientific article

Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters.

scientific article published on 11 May 2017

Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study

scientific article published on 23 July 2018

Complex coacervation-based loading and tunable release of a cationic protein from monodisperse glycosaminoglycan microgels

scientific article published on 01 August 2018

Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

scientific article published on 09 March 2020

Convallatoxin: a new P-glycoprotein substrate

scientific article published on 28 September 2014

Creating a bioartificial kidney

scientific article published on 14 June 2017

Cyclosporin increases cellular idarubicin and idarubicinol concentrations in relapsed or refractory AML mainly due to reduced systemic clearance.

scientific article

Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells

scientific article published on 28 February 2011

Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

scientific article published on 24 June 2021

Cysteamine: an old drug with new potential.

scientific article

Deficiency of Either P-Glycoprotein or Breast Cancer Resistance Protein Protect against Acute Kidney Injury

scientific article published on 04 May 2010

Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients

scientific article published on 06 May 2019

Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane.

scientific article published on 17 December 2014

Differential effects of sulfonylurea derivatives on vascular ATP-sensitive potassium channels

scientific article published on 17 February 2012

Disposition and clinical implications of protein-bound uremic toxins.

scientific article published on 30 June 2017

Drug disposition: From cradle to cane ⬇️

scientific article published on May 20, 2013

Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion

scientific article published on 12 June 2020

Effect of drugs on renal development.

scientific article

Effects of a human recombinant alkaline phosphatase on renal hemodynamics, oxygenation and inflammation in two models of acute kidney injury.

scientific article published on 16 October 2016

Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro.

scientific article published on 6 September 2013

Endothelin and calciotropic hormones share regulatory pathways in multidrug resistance protein 2-mediated transport

scientific article published on 15 August 2006

Epithelial-to-mesenchymal transition in fibrosis: Collagen type I expression is highly upregulated after EMT, but does not contribute to collagen deposition ⬇️

scientific article published on July 29, 2013

Evaluating Human Intestinal Cell Lines for Studying Dietary Protein Absorption.

scientific article published on 7 March 2018

Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity.

scientific article published on 7 March 2018

Extrahepatic metabolism of ibrutinib

scientific article published on 04 July 2020

Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds

scientific article published on 13 December 2018

Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus.

scientific article published on 19 August 2010

Fluorescence-Based Transport Assays Revisited in a Human Renal Proximal Tubule Cell Line

scientific article published on 12 February 2016

Fluorescently Labeled Cyclodextrin Derivatives as Exogenous Markers for Real-Time Transcutaneous Measurement of Renal Function.

scientific article published on 9 September 2016

From portable dialysis to a bioengineered kidney.

scientific article published on 10 April 2018

Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions.

scientific article

Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review

scientific article published on 27 September 2018

Glomerular filtration and saturable absorption of iohexol in the rat isolated perfused kidney.

scientific article published on September 1996

Heme Oxygenase-1 and breast cancer resistance protein protect against heme-induced toxicity

scientific article published on January 1, 2013

Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays.

scientific article published on 17 December 2015

Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations

scientific article published on 16 November 2015

Humans are animals, but are animals human enough? A systematic review and meta-analysis on interspecies differences in renal drug clearance

scientific article published on 03 February 2020

Humoral signalling compounds in remote ischaemic preconditioning of the kidney, a role for the opioid receptor.

scientific article

Hydrogel-based cell therapies for kidney regeneration: current trends in biofabrication and in vivo repair.

scientific article

Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP) ⬇️

scientific article published on May 9, 2013

Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice

scientific article

Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats.

scientific article

In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes

scientific article published on 11 October 2019

In vitro systems to study nephropharmacology: 2D versus 3D models

scientific article published on 6 July 2016

Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure

scientific journal article

Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect.

scientific article published on 6 July 2013

Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling

scientific article

Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells

scientific article published on 28 June 2018

Innovations in approaches to remove uraemic toxins

scientific article published on 07 May 2020

Insights into the role of bone marrow-derived stem cells in renal repair.

scientific article published on 20 March 2008

Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4.

scientific article published on 12 September 2013

Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules.

scientific article published on 19 May 2006

Iron metabolism in the pathogenesis of iron-induced kidney injury ⬇️

scientific article published on May 14, 2013

Kidney-based in vitro models for drug-induced toxicity testing

scientific article published on 29 October 2019

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening.

scientific article published on 17 December 2015

Local and Remote Ischemic Postconditionings Have Synergistic Protective Effects on Renal Ischemia-Reperfusion Injury

scientific article published on 01 July 2012

Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones.

scientific article

Low-titre inhibitors, undetectable by the Nijmegen assay, reduce factor VIII half-life after immune tolerance induction.

scientific article published in April 2012

Mechanisms and clinical implications of renal drug excretion* ⬇️

scientific article published on August 1, 2001

Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model.

scientific article published on 6 September 2017

Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport

scientific article published on 01 May 2003

Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules

scientific article published on 14 August 2018

New insights into the effects of biomaterial chemistry and topography on the morphology of kidney epithelial cells

scientific article published on 15 December 2016

Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia.

scientific article published on 12 February 2008

Novel Dietary Proteins Selectively Affect Intestinal Health In Vitro after Clostridium difficile-Secreted Toxin A Exposure

scientific article published on 11 September 2020

Optimized Metabolomic Approach to Identify Uremic Solutes in Plasma of Stage 3–4 Chronic Kidney Disease Patients ⬇️

scientific article published on August 2, 2013

Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells

scientific article published on 01 September 2019

P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury

scientific article published on 12 September 2007

Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients.

scientific article published on 31 May 2013

Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers

scientific article

Phase I/II trial of a combination of anti-CD3/CD7 immunotoxins for steroid-refractory acute graft-versus-host disease

scientific article published on 03 November 2018

Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study

scientific article published on 02 March 2011

Prophylactic effect of recombinant factor VIIa in factor VII deficient patients.

scientific article

Protein-Bound Uremic Toxins in Hemodialysis Patients Relate to Residual Kidney Function, Are Not Influenced by Convective Transport, and Do Not Relate to Outcome

scientific article published on 07 April 2020

Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury.

scientific article

Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology

scientific article published on 24 July 2015

Quantification of cystine in human renal proximal tubule cells using liquid chromatography-tandem mass spectrometry.

scientific article published on 8 March 2018

Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease

scientific article published on 27 September 2019

Rapid, nongenomic stimulation of multidrug resistance protein 2 (Mrp2) activity by glucocorticoids in renal proximal tubule.

scientific article

Recellularized Native Kidney Scaffolds as a Novel Tool in Nephrotoxicity Screening

scientific article published on 06 July 2018

Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules

scientific article

Remote ischaemic preconditioning by brief hind limb ischaemia protects against renal ischaemia-reperfusion injury: the role of adenosine

scientific article published on 21 March 2011

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

scientific article published on 24 July 2019

Renal Epithelial Monolayer Formation on Monomeric and Polymeric Catechol Functionalized Supramolecular Biomaterials

scientific article published on 14 November 2018

Renal Handling of Circulating and Renal-Synthesized Hepcidin and Its Protective Effects against Hemoglobin-Mediated Kidney Injury.

scientific article published on 29 January 2016

Renal Tubular- and Vascular Basement Membranes and their Mimicry in Engineering Vascularized Kidney Tubules

scientific article published on 09 August 2018

Renal excretion and accumulation kinetics of 2-methylbenzoylglycine in the isolated perfused rat kidney

scientific article published on 01 June 1996

Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus.

scientific article published on 10 January 2014

Rhodamine 123 accumulates extensively in the isolated perfused rat kidney and is secreted by the organic cation system

scientific article published on 01 March 1997

Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions

scientific article

Role of multidrug resistance protein 2 (MRP2) in glutathione‐bimane efflux from Caco‐2 and rat renal proximal tubule cells ⬇️

scientific article published on November 1, 2001

Role of p-glycoprotein expression and function in cystinotic renal proximal tubular cells

scientific article published on 27 October 2011

Saturable accumulation and diuretic activity of hydrochlorothiazide in the isolated perfused rat kidney

scientific article published on 01 January 1997

Screening for the role of transporters in hepatic and renal drug handling

scientific article published on 01 December 2004

Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip

scientific article published on 26 July 2018

Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes

scientific article published on 01 July 2019

Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule.

scientific article published in May 2002

Short-term beneficial effects of methylene blue on kidney damage in septic shock patients.

scientific article

Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity.

scientific article published on 5 August 2005

Spinach and Chive for Kidney Tubule Engineering: the Limitations of Decellularized Plant Scaffolds and Vasculature

scientific article published on 28 December 2020

Subunit-specific incorporation efficiency and kinetics in mitochondrial complex I homeostasis

scientific article

Switch in FGFR3 and -4 expression profile during human renal development may account for transient hypercalcemia in patients with Sotos syndrome due to 5q35 microdeletions

scientific article published on 26 March 2014

The Authors Reply

scientific article published on 01 September 2015

The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition

scientific article published on 10 September 2020

The Influence of Dietary Protein Intake on Mammalian Tryptophan and Phenolic Metabolites.

scientific article

The Virtual Human Platform for Safety Assessment (VHP4Safety) project: Next generation chemical safety assessment based on human data

scientific article published in January 2024

The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.

scientific article

The functional implications of common genetic variation in CYP3A5 and ABCB1 in human proximal tubule cells.

scientific article

The importance of breast cancer resistance protein to the kidneys excretory function and chemotherapeutic resistance

scientific article published on 11 January 2017

The kidney and uremic toxin removal: glomerulus or tubule?

scientific article

The potential of alkaline phosphatase as a treatment for sepsis-associated acute kidney injury

scientific article published on 24 September 2014

The role of ATP binding cassette transporters in tissue defense and organ regeneration.

scientific article

Therapeutic implications of renal anionic drug transporters.

scientific article published on 20 March 2010

Towards a bioengineered kidney: recellularization strategies for decellularized native kidney scaffolds.

scientific article published on 20 April 2017

Transport of a fluorescent cAMP analog in teleost proximal tubules

scientific article published on 12 September 2007

Tubular reabsorption and local production of urine hepcidin-25.

scientific article

Tubuloids derived from human adult kidney and urine for personalized disease modeling

scientific article published on 04 March 2019

Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.

scientific article

Upscaling of a living membrane for bioartificial kidney device.

scientific article published on 6 July 2016

Uremic Solutes in Chronic Kidney Disease and Their Role in Progression

scientific article

Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration.

scientific article

Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.

scientific article

Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients ⬇️

scientific article published on March 22, 2011

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