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List of works by Amjad Javed

A Runx2 threshold for the cleidocranial dysplasia phenotype

scientific article

Alterations in intranuclear localization of Runx2 affect biological activity

scientific article published on December 2006

Altered chromatin modifications in AML1/RUNX1 breakpoint regions involved in (8;21) translocation.

scientific article published in February 2009

Analysis of in vivo gene expression using epitope-tagged proteins

scientific article published on 01 January 2004

BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.

scientific article published on 23 October 2006

Biphasic peptide amphiphile nanomatrix embedded with hydroxyapatite nanoparticles for stimulated osteoinductive response.

scientific article published on 17 November 2011

Breakpoint regions ofETOgene involved in (8; 21) leukemic translocations are enriched in acetylated histone H3 ⬇️

scientific article published on November 1, 2013

CBFa(AML/PEBP2)-related elements in the TGF-beta type I receptor promoter and expression with osteoblast differentiation

scientific article published on 01 June 1998

CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression.

scientific article published on 19 October 2001

Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

scientific article published in Journal of Biological Chemistry

Cbfbeta interacts with Runx2 and has a critical role in bone development

scientific journal article

Chondrocyte-specific regulatory activity of Runx2 is essential for survival and skeletal development

scientific article

Chromatin immunoprecipitation

scientific article published on 01 January 2004

Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells.

scientific article

Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer

scientific article

Contributions of nuclear architecture and chromatin to vitamin D-dependent transcriptional control of the rat osteocalcin gene.

scientific article

Crystal structure of the nuclear matrix targeting signal of the transcription factor acute myelogenous leukemia-1/polyoma enhancer-binding protein 2alphaB/core binding factor alpha2

scientific article published on 01 November 1999

Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.

scientific article

Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype.

scientific article published in September 2001

Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.

scientific article published on October 2004

Dwarfism in homozygous Agc1CreERT mice is associated with decreased expression of aggrecan.

scientific article published on 18 September 2017

Effect of sodium hypochlorite on human pulp cells: an in vitro study.

scientific article

Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.

scientific article published on July 2004

Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair.

scientific article published on November 2003

Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

scientific article published on August 2008

Heparanase inhibits osteoblastogenesis and shifts bone marrow progenitor cell fate in myeloma bone disease.

scientific article published on 27 July 2013

Heparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cells

scientific article published on 03 February 2016

Immunofluorescence analysis using epitope-tagged proteins: in vitro system

scientific article published on 01 January 2004

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.

scientific article

In situ immunofluorescence analysis: analyzing RNA synthesis by 5-bromouridine-5'-triphosphate labeling

scientific article

In situ immunofluorescence analysis: immunofluorescence microscopy

scientific article published on 01 January 2004

In situ nuclear organization of regulatory machinery

scientific article published on 01 January 2008

Insight into regulatory factor targeting to transcriptionally active subnuclear sites.

scientific article

Intranuclear Trafficking: Organization and Assembly of Regulatory Machinery for Combinatorial Biological Control

scientific article (publication date: 23 July 2004)

Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

scientific article

Intranuclear trafficking of transcription factors: Requirements for vitamin D-mediated biological control of gene expression.

scientific article

Intranuclear trafficking of transcription factors: implications for biological control.

scientific article

Leukemia-associated AML1/ETO (8;21) chromosomal translocation protein increases the cellular representation of PML bodies

scientific article published on 01 July 2000

Loss of Runx2 in committed osteoblasts impairs postnatal skeletogenesis.

scientific article

MicroRNA 665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic Mechanisms

scientific article

Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2.

scientific article published on February 2006

Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.

scientific article

Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells

scientific journal article

Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2.

scholarly article

Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization.

scientific article

Myeloma cell-derived Runx2 promotes myeloma progression in bone.

scientific article published on 10 April 2015

Networks and hubs for the transcriptional control of osteoblastogenesis.

scientific article published on June 2006

Nuclear microenvironments in biological control and cancer.

scientific article published on June 2007

Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation

scientific article published on February 2004

Nuclear microenvironments support physiological control of gene expression

scientific article published in January 2003

Organization of transcriptional regulatory machinery in nuclear microenvironments: implications for biological control and cancer

scientific article published on 23 March 2007

Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1.

scientific article published in September 2005

Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer

scientific article published on February 2009

Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.

scientific article published on 31 March 2008

Protein-deoxyribonucleic acid interactions linked to gene expression: DNase I digestion.

scientific article published on January 2004

Protein-deoxyribonucleic acid interactions linked to gene expression: electrophoretic mobility shift assay

scientific article published on 01 January 2004

Protein-deoxyribonucleic acid interactions linked to gene expression: ligation-mediated polymerase chain reaction

scientific article published on 01 January 2004

Quantitative signature for architectural organization of regulatory factors using intranuclear informatics.

scientific article published on 14 September 2004

Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation

scientific article published on February 2007

Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity

scientific journal article

Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

scientific article

Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone.

scientific article published on December 2006

Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo.

scientific article published in August 2003

Runx2 activity in committed osteoblasts is not essential for embryonic skeletogenesis.

scientific article

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

scientific article published on May 2004

Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors

scientific article

Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation

scientific article

Runx2 regulates the gene network associated with insulin signaling and energy homeostasis

scientific article

Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions

scientific article

SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation

scientific journal article

Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription.

scientific article

Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification.

scientific article published on 06 July 2012

Sp7 and Runx2 molecular complex synergistically regulate expression of target genes

scientific article

Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation.

scientific article published on 26 August 2008

Specificity protein 7 is not essential for tooth morphogenesis.

scientific article

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.

scientific article

Subnuclear localization and intranuclear trafficking of transcription factors

scientific article published on January 2010

Subnuclear organization and trafficking of regulatory proteins: implications for biological control and cancer.

scientific article published in January 2000

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

scientific article published on 03 July 2001

Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1.

scientific article published on November 2005

The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion

scientific article

The dynamic organization of gene-regulatory machinery in nuclear microenvironments

scientific article

The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain

scientific article

Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains.

scientific article published in November 2002

Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

scientific article published on February 2009

Transcriptional Auto-Regulation of RUNX1 P1 Promoter

scientific article

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